SOS Small Cell Lung Cancer AECC

@sosclc-aecc.bsky.social

SOSCLC-AECC is a scientific network of biomedical researchers and clinicians with a focus on Small Cell Lung Cancer (SCLC) and neuroendocrine lung tumors. Coordinated by Luis Paz-Ares (H12O) and @mmalumbres.bsky.social @vhio.bsky.social, and funded by AECC

An insightful review on genetics and resistance to immunotherapies in cancer by @sosclc-aecc.bsky.social researcher @franmj88.bsky.social @vhio.bsky.social www.cell.com/trends/cance...

Genetic immune escape in cancer: timing and implications for treatment

Genetic immune escape (GIE) alterations pose a significant challenge in cancer by enabling tumors to evade immune detection. These alterations, which can vary significantly across cancer types, may often arise early in clonal evolution and contribute to malignant transformation. As tumors evolve, GIE alterations are positively selected, allowing immune-resistant clones to proliferate. In addition to genetic changes, the tumor microenvironment (TME) and non-genetic factors such as inflammation, smoking, and environmental exposures play crucial roles in promoting immune evasion. Understanding the timing and mechanisms of GIE, alongside microenvironmental influences, is crucial for improving early detection and developing more effective therapeutic interventions. This review highlights the implications of GIE in cancer development and immunotherapy resistance, and emphasizes the need for integrative approaches.

cell.com

Fran Martínez-Jiménez@franmj88.bsky.social · 2y ago

Excited to share our perspective on genetic immune escape alterations and their impact on tumor evolution, metastasis, immunotherapy, and interactions with tumor-extrinsic factors. It was a pleasure collaborating with Diego on this -hope you enjoy the read!☺️ www.sciencedirect.com/science/arti...