Victor A. Albert

@plantgenomes.bsky.social

Professor, University at Buffalo | plant genomes, polyploidy, organismal radiations, phylo/population genomics, carnivorous plants, holocentric chromosomes, evolution of biosynthetic gene clusters; https://scholar.google.com/citations?user=dLniyH0AAAAJ&

Cool new work! Some lineages experiencing ancient whole-genome duplications seem to hold on to their duplicate genes for a really long time & keep accumulating homoeologous exchange events! Runs counter to early models where gene loss is expected to be rapid post-WGD academic.oup.com/gbe/advance-...

A class of allopolyploidy showing high duplicate retention and continued homoeologous exchanges

Abstract. We describe four ancient polyploidy events where the descendant taxa retain many more duplicated gene copies than has been seen in other paleopol

academic.oup.com

Sea sandwort (Honckenya peploides) genome update - first Nanopore flow cell looking pretty good. Dormant shoots were collected from under beach sand in Denmark. A salt tolerant species that was the first plant to appear on the volcanic island Surtsey (Iceland), which erupted out of the sea in 1963.

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Sharing our combo of evolutionary genomics with plant natural products chemistry to resolve complex monoterpene indole alkaloid biosynthesis 🌿🍀🧪🧪🧬🧬 www.biorxiv.org/content/10.1...

Ancient gene clusters initiate monoterpene indole alkaloid biosynthesis and C-3 stereochemistry inversion

The inversion of C3 stereochemistry in monoterpenoid indole alkaloids (MIAs), derived from the central precursor strictosidine (3S), is essential for synthesizing numerous 3R MIAs and oxindoles, including the antihypertensive drug reserpine found in Rauvolfia serpentina (Indian snakeroot) and Rauvolfia tetraphylla (devil pepper) of the plant family Apocynaceae. MIA biosynthesis begins with the reduction of strictosidine aglycone by various reductases, preserving the initial 3S stereochemistry. In this study, we identify and biochemically characterize a conserved oxidase-reductase pair from the Apocynaceae, Rubiaceae, and Gelsemiaceae families of the order Gentianales: the heteroyohimbine/yohimbine/corynanthe C3-oxidase (HYC3O) and C3-reductase (HYC3R). These enzymes collaboratively invert the 3S stereochemistry to 3R across a range of substrates, resolving the long-standing question about the origin of 3R MIAs and oxindole derivatives, and facilitation of reserpine biosynthesis. Notably, HYC3O and HYC3R are located within gene clusters in both the R. tetraphylla and Catharanthus roseus (Madagascar periwinkle) genomes, which are partially homologous to an elusive geissoschizine synthase (GS) gene cluster we also identified in these species. In R. tetraphylla, these clusters occur closely in tandem on a single chromosome, likely stemming from a single segmental duplication event, while in C. roseus, a closely related member of rauvolfioid Apocynaceae, they were later separated by a chromosomal translocation. The ancestral genomic context for both clusters can be traced all the way back to common ancestry with grapevine. Given the presence of syntenic GS homologs in Mitragyna speciosa (Rubiaceae), the GS cluster, at least in part, likely evolved at the base of the Gentianales, which split from other core eudicots up to 135 million years ago. We also show that the strictosidine biosynthetic gene cluster, required to initiate the MIA pathway, likely evolved concurrently. The reserpine biosynthetic cluster likely arose much later in the rauvolfioid lineage of Apocynaceae. Collectively, our work uncovers the genomic and biochemical basis for key events in MIA evolution and diversification, providing insights beyond the well-characterized vinblastine and ajmaline biosynthetic pathways. ### Competing Interest Statement The authors have declared no competing interest.

biorxiv.org

One hominin fossil with a remarkable history comes from a small town near Stuttgart, Germany, called Steinheim an der Murr. Found in 1933, the scientist who studied the skull secreted it away under his bed for years to keep powerful Nazi competitors from studying it. johnhawks.net/weblog/a-loo...

A look at the fossil skull from Steinheim

The skull provides some of the best evidence for the ancestral population of Neandertals, and had a tumultuous history in the decades after its discovery.

johnhawks.net

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Rapid natural selection across the last 5000 years, a complex speciation to kick off the hominin lineage, and a single pulse of Neandertal ancestry into recent people around 47,000 years ago. Those are some of the big stories coming from DNA this year. johnhawks.net/weblog/top-1...

Top 10 discoveries about ancient people from DNA in 2024

New resolution is emerging of some events in ancient human populations, and a clearer view of some parts of the genome.

johnhawks.net