Interview with Dana S. Guggenheim, BA, and Justin S. Golub, MD, MS, authors of Newborn Hearing Screening in the Otoferlin Gene Therapy Era. Hosted by Paul C. Bryson, MD, MBA. ja.ma/4rcqAap

Among patients undergoing head and neck #FreeFlap reconstruction or #TransoralRoboticSurgery, adjunctive #Suzetrigine was associated with lower inpatient opioid use and similar postoperative pain scores. ja.ma/4Akh0Gs

💬 Editorial: A single narrative arc and the And–But–Therefore framework can help scientific findings clearly communicate the problem, the evidence gap, and the reason the audience should care. ja.ma/472YwwR

For #HeadAndNeckSquamousCellCarcinoma surveillance, tissue-informed #ctDNA positivity was sometimes the first sign of recurrence and showed high positive and negative predictive value. ja.ma/4igsx38

📣 Special Communication: In #PrimaryHyperparathyroidism, imaging should be reserved for after biochemical diagnosis, and #Ultrasonography is the preferred first study because it involves no ionizing radiation. ja.ma/4yt6ACZ

In #PapillaryThyroidCarcinoma, #TERT promoter variants increased with age across 3 cohorts, indicating that molecular status may explain much of the worse prognosis associated with older age. ja.ma/4x7bunN

📝 JAMA Otolaryngology #Review: For human papillomavirus–independent #HeadAndNeckCancer, circulating tumor DNA positivity was associated with worse survival outcomes. ja.ma/4bCkcmk

In locally advanced #HeadAndNeckCancer, perioperative #Pembrolizumab was cost-effective only for patients with programmed cell death 1 ligand 1 combined positive score >10, supporting biomarker-stratified immunotherapy use. ja.ma/3TO1amQ

In #AirwayEndoscopy, a structured #HumanFactors program was associated with fewer door openings and phone interruptions during critical phases, while short-term clinical outcomes were unchanged. ja.ma/4zb8CJ8

In locally advanced #HeadAndNeckCancer, perioperative #Pembrolizumab was cost-effective only for patients with programmed cell death 1 ligand 1 combined positive score >10, supporting biomarker-stratified immunotherapy use. ja.ma/45NpCYc

In #AirwayEndoscopy, a structured #HumanFactors program was associated with fewer door openings and phone interruptions during critical phases, while short-term clinical outcomes were unchanged. ja.ma/4wXcz2n

In a multicenter cohort of patients with type 2 #Diabetes, use of glucagon-like peptide-1 receptor agonists (#GLP-1 RAs) was associated with increased risk of smell and taste disturbances compared with other #antidiabetic medications. ja.ma/4wORmrt

#HypoglossalNerveStimulation is an implanted device for #ObstructiveSleepApnea that stimulates the tongue nerve during sleep to help keep the airway open—an option for patients who cannot use CPAP. ja.ma/4vXiJPo

Among adults with type 2 #Diabetes, GLP-1 receptor agonist use was associated with greater risk of smell and taste disturbances compared with other antidiabetic medications. ja.ma/4aJSgwn

Dried blood spot (#DBS) PCR showed 86% sensitivity and 99.5% specificity for cCMV detection in #newborns identified by expanded targeted #testing, especially those with moderate to severe #disease. ja.ma/4aILabA

Among patients undergoing head and neck #Reconstruction, quality-of-life did not stabilize at 1 year, with complications at 12 months being the most prominent modifiable risk factor for deterioration. ja.ma/4vZ0vNK

This case report describes a woman in her 50s with a 4-month history of oral ulcers and a previous diagnosis of mononucleosis. ja.ma/4e0FD21

Undiagnosed Syphilis Presenting as Recurrent Oral Ulcers

This case report describes a woman in her 50s with a 4-month history of oral ulcers and a previous diagnosis of mononucleosis.

ja.ma

A 75-year-old male with a history of chronic rhinosinusitis and prior sinus surgery presented with symptoms of persistent nasal congestion, drainage, and ocular irritation with blurred vision and discharge. What is your diagnosis? ja.ma/4oo9V2n

Chronic Sinusitis With Orbitonasal Bony Defect

A 75-year-old male with a history of chronic rhinosinusitis and prior sinus surgery presented with symptoms of persistent nasal congestion, drainage, and ocular irritation with blurred vision and discharge. What is your diagnosis?

ja.ma

A 41-year-old patient was referred to the oral and maxillofacial surgery department with slight mobility of the upper right canine with occasional swelling. What is your diagnosis? ja.ma/4v4u7sk

A Patient With Tooth Mobility and a Maxillary Lesion

A 41-year-old patient was referred to the oral and maxillofacial surgery department with slight mobility of the upper right canine with occasional swelling. What is your diagnosis?

ja.ma

Among patients undergoing head and neck #Reconstruction, quality-of-life did not stabilize at 1 year, with complications at 12 months being the most prominent modifiable risk factor for deterioration. ja.ma/3SIV0nq

📝 Scoping review: Validated #SDoH tools for #HeadAndNeckCancer mostly assess economic stability, with limited measurement of social context, health care access, or environment. ja.ma/43Q6IPB

In a cohort study of patients undergoing #TransoralRoboticSurgery, subjective swallowing worsened at 6 weeks for many patients, but objective studies showed preserved function and most were tolerating a soft to regular diet. ja.ma/4gdbkqe

Swallowing Function and Perioperative Complications After Transoral Robotic Surgery

This cohort study assesses the early postoperative swallow function of patients who underwent transoral robotic surgery resection of early-stage oropharyngeal squamous cell carcinoma prior to initiation of adjuvant therapy or at 6 weeks postoperatively if adjuvant therapy was not given.

ja.ma

Routine postdissection V2 stimulation during #thyroidectomy improved detection of nerve injury risk and may prevent bilateral vocal cord palsy compared to selective or R2-only monitoring. ja.ma/3QZziem

Otolaryngology surgeons showed high intraoperative ergonomic risk and acute pain, with increased risk linked to procedure difficulty, glove size, and age ≥40 years. ja.ma/4uJmvKP

In patients with #HPV-associated #OropharyngealCancer, definitive treatment with deintensified 60‑Gy #Radiotherapy, with or without chemotherapy, was associated with low long-term locoregional recurrence and favorable survival outcomes. ja.ma/4vokCoj

In adults with recurrent acute #Rhinosinusitis, endoscopic sinus surgery was more effective than medical treatment alone for achieving clinically meaningful improvement in symptoms. ja.ma/44qs8CV

Among survivors of #Oropharyngeal #Cancer, higher MD Anderson Symptom Inventory–Head and Neck symptom scores were associated with later risk of #HypoglossalNeuropathy, supporting early patient-reported symptom surveillance. ja.ma/4elOxqX

A 25-year-old female patient reported noticing a lesion in the left maxillary region 8 years prior and presented with an enlarged left-sided facial mass. 📝 What is your diagnosis?

Progressive Maxillary Hyperplasia With Generalized Cutaneous Lesions

A 25-year-old female patient reported noticing a lesion in the left maxillary region 8 years prior and presented with an enlarged left-sided facial mass. What is your diagnosis?

jamanetwork.com

Pembrolizumab combined with quad-shot radiotherapy was feasible and achieved a 47% response rate in patients with recurrent or metastatic #HeadAndNeckCancer, warranting further randomized trials. ja.ma/4xyOYG9

Machine learning models in #TongueCancer surgery provided individualized prediction of major 30-day complications, including bleeding, surgical site infection, and pneumonia, with performance comparable to ACS-NSQIP. ja.ma/4eQu3H4