In #SensorineuralHearingLoss, pure-tone average phenotyping identified more genome-wide significant loci and higher heritability than diagnostic code–based phenotyping. ja.ma/4ydZ7Hn

Among patients receiving radiotherapy for #HeadAndNeckCancer, higher skeletal muscle and lower intermuscular adiposity on pretreatment #ComputedTomography were associated with improved overall survival. ja.ma/4zsBVWC

In #SensorineuralHearingLoss, pure-tone average phenotyping identified more genome-wide significant loci and higher heritability than diagnostic code–based phenotyping. ja.ma/3TzNFHQ

Among patients receiving radiotherapy for #HeadAndNeckCancer, higher skeletal muscle and lower intermuscular adiposity on pretreatment #ComputedTomography were associated with improved overall survival. ja.ma/4rUgVFM

In #SensorineuralHearingLoss, pure-tone average phenotyping identified more genome-wide significant loci and higher heritability than diagnostic code–based phenotyping. ja.ma/4yMY0zl

Among patients receiving radiotherapy for #HeadAndNeckCancer, higher skeletal muscle and lower intermuscular adiposity on pretreatment #ComputedTomography were associated with improved overall survival. ja.ma/4hAMGQQ

Persistent unilateral #Sinonasal obstruction with a maxillary sinus mass and palatal erosion may indicate sinonasal ameloblastoma, a rare locally infiltrative odontogenic epithelial tumor. ja.ma/4AIvPTo

A tracheostomy-specific #Tracheostomy risk-tier system for children separated prolonged hospitalization and in-hospital mortality better than All Patient Refined Diagnosis Related Group severity classification. ja.ma/4rpdJle

For patients with #ObstructiveSleepApnea treated with hypoglossal nerve stimulation, low arousal threshold was associated with a shift from 3-month adherence to 6-month nonadherence. ja.ma/4roCjTf

A 34-year-old man with no significant medical history presented with progressive dysphonia, dysphagia, and an infiltrative laryngeal mass that remained nondiagnostic on multiple biopsies. What was the diagnosis? ja.ma/4dNuEbt

Interview with Dana S. Guggenheim, BA, and Justin S. Golub, MD, MS, authors of Newborn Hearing Screening in the Otoferlin Gene Therapy Era. Hosted by Paul C. Bryson, MD, MBA. ja.ma/4rcqAap

Among patients undergoing head and neck #FreeFlap reconstruction or #TransoralRoboticSurgery, adjunctive #Suzetrigine was associated with lower inpatient opioid use and similar postoperative pain scores. ja.ma/4Akh0Gs

💬 Editorial: A single narrative arc and the And–But–Therefore framework can help scientific findings clearly communicate the problem, the evidence gap, and the reason the audience should care. ja.ma/472YwwR

For #HeadAndNeckSquamousCellCarcinoma surveillance, tissue-informed #ctDNA positivity was sometimes the first sign of recurrence and showed high positive and negative predictive value. ja.ma/4igsx38

📣 Special Communication: In #PrimaryHyperparathyroidism, imaging should be reserved for after biochemical diagnosis, and #Ultrasonography is the preferred first study because it involves no ionizing radiation. ja.ma/4yt6ACZ

In #PapillaryThyroidCarcinoma, #TERT promoter variants increased with age across 3 cohorts, indicating that molecular status may explain much of the worse prognosis associated with older age. ja.ma/4x7bunN

📝 JAMA Otolaryngology #Review: For human papillomavirus–independent #HeadAndNeckCancer, circulating tumor DNA positivity was associated with worse survival outcomes. ja.ma/4bCkcmk

In locally advanced #HeadAndNeckCancer, perioperative #Pembrolizumab was cost-effective only for patients with programmed cell death 1 ligand 1 combined positive score >10, supporting biomarker-stratified immunotherapy use. ja.ma/3TO1amQ

In #AirwayEndoscopy, a structured #HumanFactors program was associated with fewer door openings and phone interruptions during critical phases, while short-term clinical outcomes were unchanged. ja.ma/4zb8CJ8

In locally advanced #HeadAndNeckCancer, perioperative #Pembrolizumab was cost-effective only for patients with programmed cell death 1 ligand 1 combined positive score >10, supporting biomarker-stratified immunotherapy use. ja.ma/45NpCYc

In #AirwayEndoscopy, a structured #HumanFactors program was associated with fewer door openings and phone interruptions during critical phases, while short-term clinical outcomes were unchanged. ja.ma/4wXcz2n

In a multicenter cohort of patients with type 2 #Diabetes, use of glucagon-like peptide-1 receptor agonists (#GLP-1 RAs) was associated with increased risk of smell and taste disturbances compared with other #antidiabetic medications. ja.ma/4wORmrt

#HypoglossalNerveStimulation is an implanted device for #ObstructiveSleepApnea that stimulates the tongue nerve during sleep to help keep the airway open—an option for patients who cannot use CPAP. ja.ma/4vXiJPo

Among adults with type 2 #Diabetes, GLP-1 receptor agonist use was associated with greater risk of smell and taste disturbances compared with other antidiabetic medications. ja.ma/4aJSgwn

Dried blood spot (#DBS) PCR showed 86% sensitivity and 99.5% specificity for cCMV detection in #newborns identified by expanded targeted #testing, especially those with moderate to severe #disease. ja.ma/4aILabA

Among patients undergoing head and neck #Reconstruction, quality-of-life did not stabilize at 1 year, with complications at 12 months being the most prominent modifiable risk factor for deterioration. ja.ma/4vZ0vNK

This case report describes a woman in her 50s with a 4-month history of oral ulcers and a previous diagnosis of mononucleosis. ja.ma/4e0FD21

Undiagnosed Syphilis Presenting as Recurrent Oral Ulcers

This case report describes a woman in her 50s with a 4-month history of oral ulcers and a previous diagnosis of mononucleosis.

ja.ma

A 75-year-old male with a history of chronic rhinosinusitis and prior sinus surgery presented with symptoms of persistent nasal congestion, drainage, and ocular irritation with blurred vision and discharge. What is your diagnosis? ja.ma/4oo9V2n

Chronic Sinusitis With Orbitonasal Bony Defect

A 75-year-old male with a history of chronic rhinosinusitis and prior sinus surgery presented with symptoms of persistent nasal congestion, drainage, and ocular irritation with blurred vision and discharge. What is your diagnosis?

ja.ma

A 41-year-old patient was referred to the oral and maxillofacial surgery department with slight mobility of the upper right canine with occasional swelling. What is your diagnosis? ja.ma/4v4u7sk

A Patient With Tooth Mobility and a Maxillary Lesion

A 41-year-old patient was referred to the oral and maxillofacial surgery department with slight mobility of the upper right canine with occasional swelling. What is your diagnosis?

ja.ma

Among patients undergoing head and neck #Reconstruction, quality-of-life did not stabilize at 1 year, with complications at 12 months being the most prominent modifiable risk factor for deterioration. ja.ma/3SIV0nq