UCT Epi & Biostats

@epibiostats-uct.bsky.social

Division of Epidemiology & Biostatistics in School of Public Health at the University of Cape Town. Please use website for official contact: https://health.uct.ac.za/school-public-health/divisions/epidemiology-and-biostatistics

Join us this Wednesday in person for the (con)Founders Journal Club. Dr Claire Davies will be presenting exciting work on inflammation phenotypes in children with perinatally acquired HIV. 📅 Wednesday 5 August 🕛 12-1pm 📍 HEU Boardroom

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Q: What is the most pressing issue for social epi in your region? A: Social & economic inequalities are obvious & ubiquitous–-so much so that we can become accustomed & let them drift to the back of our minds. The most pressing issue is making sure health inequality is constantly part of our work.

Q: Why did you join I-SES? A: To help bring more attention to the role of social epidemiology in promoting population health in sub-Saharan Africa–the social determinants of health are so deeply ingrained in many settings here that epidemiologic research overlooks their pivotal & modifiable roles.

🧠 New insights from DolPHIN-2 PLUS: In 3–4-year-olds, no significant brain structure differences between HIV-exposed uninfected and unexposed children, or by prenatal ART (DTG vs EFV). Results support DTG use in late pregnancy but ongoing monitoring is needed. academic.oup.com/jpids/articl...

Brain Structure of South African Children Born to Mothers on Dolutegravir Versus Efavirenz-Based Antiretroviral Therapy

AbstractBackground. The impact of in utero exposure to specific antiretroviral therapy (ART), particularly integrase strand transfer inhibitors, on early b

academic.oup.com

This week we joined UCT StatsGeeks Society for a talk introducing undergrads to Biostats. We shared insights into what we do and what makes our work rewarding. We love contributing to growing the next gen of biostatisticians and data-driven scientists at UCT!

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🔍New insights on hyperglycaemia in pregnancy (HIP) in Africa 📈The prevalence of adverse outcomes related to HIP in for mothers and babies is high 📌We need earlier screening, improved access to care, and context‑appropriate clinical guidelines 👉🏾Read the article: journals.plos.org/plosone/arti...

Outcomes of hyperglycaemia in pregnancy in Africa: Systematic review and meta-analysis

Objective The global prevalence of type 2 diabetes mellitus has significantly risen in recent decades, leading to a corresponding increase in the incidence of diabetes-complicated pregnancies. Hyperglycaemia in pregnancy (HIP), the most common metabolic complication encountered during pregnancy, is associated with a range of adverse maternal and foetal outcomes. This systematic review comprehensively examined the maternal, foetal, neonatal, childhood, and long-term maternal outcomes of HIP in Africa. Methods A systematic review of all studies investigating HIP outcomes in Africa from January 1998 to February 2025 was undertaken. We searched PubMed-MEDLINE, Cochrane Library, Scopus, CINAHL (EBSCOhost), Embase and Web of Science databases for eligible studies. Studies were included if they were observational studies describing outcomes of HIP in Africa. For each outcome, study results were synthesised using an inverse variance heterogeneity meta-analysis with the Freeman-Tukey transformation. Heterogeneity was assessed using the I2 statistic, and publication bias was assessed using Doi plots. Results Thirty studies were included in the review, comprising 9742 participants. These studies were conducted across the following African countries: South Africa (n = 11), Ethiopia (n = 4), Nigeria (n = 3), Sudan (n = 3), Uganda (n = 2), and one each from Ghana, Algeria, Morocco, Democratic Republic of Congo, Zimbabwe, Togo, and Egypt. The most common adverse pregnancy outcomes for gestational diabetes mellitus (GDM) were caesarean section (CS) (overall prevalence 46.0%, 95% CI 35.7–56.4, I2 = 95.6%), preterm delivery (overall prevalence 25.2% (95% CI 12.7–40.2, I2 = 96.7%) and neonatal intensive care unit (NICU) admission (overall prevalence 25.9% (95% CI 13.7–40.2, I2 = 85.7%). The most common adverse pregnancy outcomes for women with preexisting type 1 diabetes (T1DM) were CS (overall prevalence 57.5%, 95% CI 44.9–69.7, I2 = 81.2%), preterm delivery (overall prevalence 50.7%, 95% CI 16.3–84.8, I2 = 92.6%), and neonatal hypoglycaemia (overall prevalence 20.2%, 95% CI 0.0–61.4, I2 = 94.6%). CS (overall prevalence 60.6%, 95% CI 45.5–74.8, I2 = 93.6%) and preterm delivery (overall prevalence 35.2%, 95% CI 29.5–41.1, I2 = 49.3%) were the most prevalent adverse pregnancy outcomes for women with preexisting type 2 diabetes (T2DM). Postpartum T2DM was the most common long-term adverse outcome of women who had GDM or hyperglycaemia first detected in pregnancy (HFDP). There was significant heterogeneity across most outcomes. Conclusions The prevalence of adverse outcomes of HIP in Africa is high, in particular CS, preterm delivery and neonatal hypoglycaemia, with higher frequencies in pregestational T1DM and T2DM compared to GDM. Additionally, T2DM prevalence in women post-GDM is about 50%. The outcome data predominantly come from a few studies, indicating the necessity for more high-quality research to improve HIP-related maternal and child health in Africa. The high heterogeneity across most outcomes suggests that their prevalence varies across populations and underscores the need for more high-quality data. PROSPERO Registration Number: CRD42020184573.

journals.plos.org

Last week we partnered with Central Library for Libraries Week to introduce high school learners to public health. Students explored the role of an epidemiologist and took part in a hands‑on outbreak investigation game. Thanks to Central Library and everyone who joined!

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