Antibacterial Efficacy of 6-Gingerol Alone and in Combination With Enrofloxacin Against Multidrug-Resistant Staphylococcus aureus Isolated From Goats - PubMed

These findings demonstrate that rapid field diagnostics are effective for mastitis screening and suggest that 6-gingerol, particularly in combination with enrofloxacin, may serve as a promising adjunct...

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Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK-Binding Osteoclastogenic Factor - PubMed

Streptococci, Gram-positive opportunistic pathogens, can cause inflammatory bone diseases, yet their virulence factors remain unclear. We investigated streptococcal components contributing to bone pathology....

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Cardiovascular Implantable Electronic Device Infections Requiring Extraction: A National Analysis of Contemporary Trends, Clinical Predictors, and Economic Burden, 2016-2022 - PubMed

In this contemporary, nationally representative ICD-10 era cohort, the CIED infection rate requiring extraction remained low and stable at 0.024%, yet these events carried outsized clinical and economic...

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Genetic architecture and functional dynamics of integrons in Staphylococcus aureus resistance - PubMed

Staphylococcus aureus is a major opportunistic pathogen and a leading cause of community and hospital-acquired infections worldwide, with a growing capacity to develop multidrug resistance (MDR). Among...

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Multidrug-resistant livestock-associated ST9-MRSA causing severe human infection without animal exposure: the food chain as a potential transmission route in China - PubMed

ST9 methicillin-resistant Staphylococcus aureus (MRSA) is a typical livestock-associated lineage in Asia and represents an important reservoir of antimicrobial resistance (AMR). However, its contribution...

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Engineered Nanozyme-Hydrogel Spray with Microwave-Fueled Self-Amplifying Catalysis for Precise Methicillin-Resistant Staphylococcus aureus-Infected Diabetic Wound Therapy - PubMed

Diabetic chronic wounds present formidable clinical challenges due to a vicious cycle of methicillin-resistant Staphylococcus aureus (MRSA) infections, persistent hypoxia, and chronic inflammation. We...

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Genomic Characterization of a Rare Methicillin-Susceptible Staphylococcus aureus ST72 Isolate Co-Harboring Panton-Valentine Leukocidin and Toxic Shock Syndrome Toxin-1 Encoding Genes from Northern Vietnam - PubMed

Staphylococcus aureus (S. aureus) possesses a diverse repertoire of virulence determinants that enable it to cause pathologies that span from mild, superficial skin and soft tissue involvements to severe,...

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Factors Affecting the Initial Serum Concentration of Teicoplanin in Pediatric Patients: A Single-Center Retrospective Analysis - PubMed

Clinical conditions, such as FN and BMT, which cause an increase in eGFR, may affect the initial Ctrough in pediatric patients. Moreover, a higher LD was well-tolerated. When determining the LD, clinical...

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CLINICAL CHARACTERISTICS OF INFECTION-ASSOCIATED PALMOPLANTAR DERMATOSIS IN PREPUBERTAL CHILDREN: AN OBSERVATIONAL STUDY - PubMed

In prepubertal children, the majority of palmoplantar dermatoses associated with infections characterized by a predominantly symmetrical and uniform rash. Treatment recommendations focus on the treatment...

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A fluorogenic biotracer for reliable detection of staphylococcal beta-lactamase: towards improved precision therapy in severe MSSA infections - PubMed

This novel assay for the detection of staphylococcal beta-lactamase demonstrated simplicity, rapidity and excellent accuracy after 24 h incubation (100% sensitivity and specificity) across a genetically...

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Immunization with PLGA-encapsulated recombinant staphylococcal enterotoxin C confers protection against intramammary Staphylococcus aureus challenge in a murine mastitis model - PubMed

Mastitis caused by Staphylococcus aureus remains a significant challenge to control due to increasing antimicrobial resistance and the limited efficacy of existing vaccines. Staphylococcal enterotoxin...

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Activity of Thiourea-Linked Diamidines against Multidrug-Resistant Staphylococcus aureus - PubMed

Staphylococcus aureus is a leading cause of antibiotic-resistant infections worldwide. Therefore, there is a constant need to develop new growth inhibitors. Pentamidine analogs (PAs) composed of thiourea-linked...

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Clinically Relevant Altered Antibiotic Responses and Mechanisms of β-Lactam Sensitization of MRSA in Cystic Fibrosis Artificial Sputum - PubMed

Staphylococcus aureus is the most common bacterial pathogen affecting pediatric patients with cystic fibrosis (CF), a genetic disorder that causes thick mucus buildup in the lungs, providing a scaffold...

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Candida albicans activates Staphylococcus aureus virulence regulatory systems to drive toxin-mediated human cell death - PubMed

Co-infection with Staphylococcus aureus and Candida albicans leads to worsened disease severity compared to mono-microbial infection. Because our understanding of the mechanisms driving enhanced disease...

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Methicillin-resistant Staphylococcus aureus - PubMed

Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of antimicrobial-resistant infection worldwide. The spectrum of diseases caused by MRSA range from uncomplicated skin and soft-tissue...

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Longitudinal Changes in Clonal Distribution and Fluoroquinolone Resistance of Ocular MRSA - PubMed

Ocular MRSA infections in Taiwan demonstrate longitudinal changes in clonal distribution, characterized by declining CC59 and increasing CC8, and a concurrent increase in fluoroquinolone-resistant CC8....

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Bedside external ventricular drainage in the NICU: procedural efficiency and infection trends in a 15-year single-center cohort - PubMed

Bedside NICU EVD insertion was substantially faster than operating-room insertion after adjustment for case-mix differences. Culture-positive infections occurred only during bedside catheter episodes;...

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Concentration-dependent dual effects of bacterial nanocellulose on Staphylococcus aureus virulence and human dermal fibroblast function: implications for wound healing - PubMed

BNC exhibits opposing concentration-dependent effects: antivirulence at cytotoxic concentrations versus immunomodulatory and pro-regenerative at safe concentrations. Unmodified BNC is unsuitable as a...

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Comparative genomic and functional analysis of Staphylococcus caprae clinical isolates: insights into genetic diversity and opportunistic pathogenic potential - PubMed

Staphylococcus caprae, a coagulase-negative staphylococcus (CoNS), is an opportunistic microorganism increasingly identified in clinical specimens. However, its genomic and functional characterization...

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Virulence determinants and multidrug resistance profiles of biofilm-forming Staphylococcus aureus from healthy orthopedic surgical personnel - PubMed

Staphylococcus aureus (S. aureus) is a clinically significant opportunistic pathogen and a leading cause of healthcare-associated infections, particularly in surgical settings. This study aimed to investigate...

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Spinal Epidural Abscess During a Spinal Cord Stimulation Trial in Complete Spinal Cord Injury: A Case Report - PubMed

Chronic pain after spinal cord injury (SCI) is often refractory to medication, and spinal cord stimulation (SCS) may provide relief. We report a 48-year-old man with complete thoracic SCI who underwent...

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Epithelial-Dermal Immune Memory: Tracking Staphylococcus aureus-Induced Trained Immunity in the Progression of Chronic Skin Inflammation - PubMed

The clinical paradigm distinguishing chronic atopic dermatitis (AD) from acute bacterial infections is established by the emerging evidence which focuses on persistent innate immune memory as a central...

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Search for Potentially Virulent Staphylococcus epidermidis Isolated from Healthy Human Skin - PubMed

Genomic studies suggest that the skin microbiota of healthy individuals may harbor <i>Staphylococcus epidermidis</i> strains with putative virulence-associated characteristics, and that contamination...

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Fibroblasts resist Staphylococcus aureus on the skin surface by responding to interleukin-1 and recruiting neutrophils - PubMed

<span><i>Staphylococcus aureus</i> can cause serious infections, yet it can also reside on the skin without causing disease. This apparent paradox implies a strong host defense system, which prevents...

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Profile, risk factors, genotype and outcome of Staphylococcus aureus catheter related blood stream infection in a Malaysian tertiary hospital - PubMed

S. aureus was the predominant agent for CRBSI and 44.2% of them were complicated. CKD/ESRF were the comorbidities associated with S. aureus CRBSI. Although cap8 was the most frequently detected virulence...

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Trends in Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections in Hospitalized Children - PubMed

We evaluated trends in Methicillin-Resistant Staphylococcus aureus (MRSA) hospitalizations and antimicrobial use from 2016 to 2024 across 40 US children's hospitals. The rate of MRSA cases per 1000 hospitalizations...

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Integration of cefradine-modified dextran-coated magnetite nanoparticles and IgG-modified time-resolved fluorescent microsphere with improved performance for ultrasensitive detection of Staphylococcus aureus in clinical samples - PubMed

An improved strategy based on dual-specificity recognition synergy for ultrasensitive detection of viable Staphylococcus aureus (S. aureus) in clinical samples is proposed. A hydrophilic cefradine-modified...

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Lacticaseibacillus paracasei-derived extracellular vesicles enhance the in vitro efficacy of methylene blue-mediated photodynamic therapy against multidrug-resistant Staphylococcus aureus - PubMed

The increasing incidence of methicillin-resistant Staphylococcus aureus (MRSA) highlights the need for antimicrobial strategies that minimize the use of antibiotics. Although antimicrobial photodynamic...

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Host autophagy in Staphylococcus aureus infection: Mechanisms of clearance, evasion, and therapeutic intervention - PubMed

Staphylococcus aureus is a facultative intracellular pathogen that persists within both professional and non-professional phagocytes, contributing to chronic and antibiotic-resistant infections. Autophagy,...

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Staphylococcal Extracellular Complement-Binding Protein Induces IL-4 Production in Murine Basophils - PubMed

Staphylococcus aureus is responsible for a wide range of pyogenic infections, food poisoning, and allergic inflammation. S. aureus produces a very wide variety of proteinaceous exotoxins, which are classified...

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