Handheld near-infrared spectroscopy for detecting staphylococcal inoculation-associated changes in ex vivo human bone - PubMed

Bone infections remain diagnostically challenging because current standard methods rely on microbiological and histopathological testing, which are time-consuming and may delay treatment decisions. This...

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A rapid approach to detect methicillin-resistant and susceptible Staphylococcus aureus directly from clinical specimens - PubMed

Screening of methicillin-resistant/susceptible <i>Staphylococcus aureus</i> (MRSA/MSSA) is important for healthcare facilities to prevent hospital-acquired infections. The two common MRSA screening approaches...

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Discovery of isokurarinone as an ATCase-engaging lead with potent activity against methicillin-resistant Staphylococcus aureus - PubMed

The global proliferation of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) persists as a significant contributor to challenging infections, highlighting the urgent necessity for therapies that...

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Disruption of ytrE attenuates methicillin-resistant Staphylococcus aureus virulence and compromises membrane integrity and oxidative stress resistance - PubMed

Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of invasive infections, yet the genetic basis of its stress adaptation remains partially understood. This study investigates the role...

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Quaternary Ammonium-Functionalized Membrane-Anchored Photosensitizer against Multidrug-Resistant Bacterial Infections - PubMed

The discovery of new antimicrobial medications has not kept up with the evolution of bacterial resistance, and infections with drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus...

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Intracranial abscess and otitis interna treated by temporal burr-hole craniotomy and ventral bulla osteotomy in a Maine coon cat - PubMed

A 1-year-old Maine coon cat was presented with acute onset of central vestibular syndrome and recurrent generalized tonic-clonic seizures. Computed tomographic imaging of the head revealed a left-sided...

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Prospective surveillance of Staphylococcus aureus bacteremia (SAB) using spa typing to identify MRSA transmission in a tertiary care setting - PubMed

The spa gene of Staphylococcus aureus encodes protein A, a key virulence factor contributing to molecular typing. spa typing provides valuable information encoding diversity and transmission, particularly...

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Nitrendipine synergizes with multiple antibiotics against methicillin-resistant Staphylococcus aureus by disrupting membrane homeostasis - PubMed

The emergence of multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) necessitates the development of innovative therapeutic strategies, including the repurposing of...

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Antimicrobial selection and multidrug resistance in four major pathogens in the US Veterans Affairs health-care system: a multicentre, retrospective, cohort study - PubMed

US Centers for Disease Control and Prevention, the Agency for Healthcare Research and Quality, and the Department of Veterans Affairs.

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The evolving landscape of Staphylococcus aureus immune evasion: a data-driven atlas over two decades - PubMed

Research on <i>S. aureus</i> immune evasion is transitioning from foundational mechanistic studies toward multi-omics integration and clinical translation. Future efforts should transcend single-target...

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Staphylococcus Aureus Toxic Shock Syndrome With Urinary Tract Infection - PubMed

Staphylococcus aureus urinary tract infection is an exceedingly rare source of toxic shock syndrome. Clinicians should maintain a high index of suspicion for TSS in patients with any staphylococcal infection...

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A non-bactericidal antimicrobial peptide provides protective effect against bacterial sepsis via regulation of antimicrobial immunity and vascular endothelial functions - PubMed

The anti-infective properties of bactericidal antimicrobial peptides (AMPs) have been extensively studied, yet the functions and mechanisms of non-bactericidal AMPs in sepsis remain poorly understood....

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Spermine conjugates of non-steroidal anti-inflammatory drugs as potent antibacterials against multidrug-resistant S. aureus and Enterococcus sp - PubMed

The rapid emergence of multidrug-resistant (MDR) bacterial pathogens necessitates the development of new antibacterial chemotherapeutics with improved efficacy and additional therapeutic benefits. Here,...

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Frequency of nasal carriers of methicillin-resistant Staphylococcus aureus among health personnel in Ayacucho, Peru - PubMed

In the studied sample, approximately one in ten healthcare workers was a nasal carrier of MRSA. Given the convenience sampling, the findings should not be extrapolated as population prevalence. Strengthening...

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Methicillin-resistant Staphylococcus aureus (MRSA) infection in hospitalized patients is dominated by community-acquired strains: genomic epidemiological evidence - PubMed

The ST59-IVa clone is the predominant MRSA strain in Ningxia hospitals, exhibiting multidrug resistance and virulence gene profiles consistent with national trends. However, the emergence of hypervirulent...

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[Clinical characteristics of periorbital and orbital cellulitis in children] - PubMed

<span><b>Objective:</b> To analyze the clinical characteristics, causative pathogens, complications, and treatment outcomes of orbital cellulitis in children. <b>Methods:</b> A retrospective cohort study...

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Abstract: Incidence of Pathogens in First Episode of Diabetic Foot Infections and Frequency of Empiric Coverage of Pathogens in Emergency Department and on Hospital Admission: A Retrospective Cohort Study - PubMed

The study demonstrated rates of MRSA and Pseudomonas consistent with prior literature. However, rates of anaerobic organisms, which have historically been less studied in DFIs, were prominent. Despite...

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Abstract: What the Skin Reveals: A Reflection on Dermatologic Disease and Structural Vulnerability - PubMed

A man experiencing homelessness presented to the emergency department with extensive involvement of ulcerative lesions. On examination, the lesions were painful, numerous, crusted, and deeply ulcerated....

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Abstract: MRSA-Associated Acute Purulent Pericarditis: A Case Report - PubMed

This case illustrates the diagnostic challenges and management considerations for MRSA-associated purulent pericarditis in a frail host. Early echocardiography and pericardiocentesis are critical in management....

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Investigation of certain miRNA expression levels in bovine mastitis cases caused by Escherichia coli and Coagulase-Negative Staphylococci - PubMed

MicroRNAs (miRNAs) are small, non-coding RNA molecules approximately 18-25 nucleotides in length that function as essential regulators in numerous biological processes, including immune system function...

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Whole-genome sequencing of Staphylococcus capitis isolates from neonates with healthcare-associated bacteraemia in neonatal intensive care units in Taiwan: comparison between the NRCS-A strain and a non-NRCS-A multi-resistant strain - PubMed

<span><i>Staphylococcus capitis</i> is a common pathogen causing late-onset sepsis in neonatal intensive care units (NICUs). A specific clone, <i>S. capitis</i> NRCS-A, which was first reported in 2012...

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Long-Term Trends in Microbiology and Outcomes of Pediatric Deep Neck Infections: An 18-Year Study - PubMed

Over 18 years, pediatric DNI in Taiwan demonstrated a marked shift toward conservative, antibiotic-based management with sustained excellent outcomes. Concurrently, MRSA and anaerobes such as <i>Veillonella</i>...

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Idiopathic primary sternal osteomyelitis in an otherwise healthy patient - PubMed

Primary sternal osteomyelitis (PSO) is an exceptionally rare infection of the sternum, typically occurring in the context of trauma, surgery or immunocompromise. We report the case of a previously healthy...

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Genetic engineering of Staphylococcus haemolyticus: overcoming restriction-modification barriers and targeting virulence genes - PubMed

<span><i>Staphylococcus haemolyticus</i> is an emerging multidrug-resistant nosocomial pathogen noted for robust biofilm formation and complex restriction-modification (RM) systems that hinder genetic...

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Molecular characteristics and pathogenicity-associated phenotypes of methicillin-resistant Staphylococcus aureus sequence type 398 clinical isolates from a women and children's hospital in Southwest China - PubMed

The obtained clinical MRSA ST398 isolates predominantly belonged to the ST398-V-t011 lineage and had a <i>mecA</i>-positive beta-lactam-resistant phenotype with variable non-beta-lactam resistance. Although...

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Berberine alleviates biofilm-associated immune-inflammatory injury in Staphylococcus aureus-induced osteomyelitis: insights from network pharmacology and experimental validation - PubMed

These findings suggest that BBR exerts protective effects against SA-induced OM through antibiofilm and anti-inflammatory activities. However, its antibacterial efficacy was weaker than that of CLD, indicating...

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Multidrug Resistance and mup A-Mediated Mupirocin Resistance in Clinical Coagulase-Negative Staphylococci - PubMed

Coagulase-negative staphylococci (CoNSs) are major opportunistic pathogens in healthcare settings, particularly affecting immunocompromised patients and those with indwelling medical devices. Their growing...

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Population Pharmacokinetic and Exposure-Response Analysis of Vancomycin Nephrotoxicity in Cystic Fibrosis Patients - PubMed

Our results demonstrate an association between increased vancomycin exposures and risk of nephrotoxicity. This study provides a foundation for optimizing personalized vancomycin dosing strategies in PwCF...

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The metabolic trap: Candida parapsilosis inhibits Staphylococcus aureus biofilm maturation by disrupting pH homeostasis and inducing premature exodus - PubMed

<span><b>Introduction.</b> Hospital-acquired infections (HAIs) frequently manifest as device-related biofilms that exhibit enhanced tolerance to conventional therapies contributing to antimicrobial resistance....

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Understanding Community Perspectives on Staphylococcus aureus Disease and Prevention in the White Mountain Apache Tribal Community in Arizona - PubMed

<span><i>Staphylococcus aureus</i> (Staph) infections are a pressing health concern in the White Mountain Apache (WMA) Tribal community, where invasive Staph infection rates far exceed those in the general...

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