We present a site‑saturation functional screens of missense variants in the high-risk breast cancer susceptibility gene PALB2. Damaging missense variants confer a high risk of breast cancer! Thanks to all co-authors and to KWF for financially supporting our work! www.nature.com/articles/s41...

Site-saturation functional screens identify PALB2 missense variants associated with increased breast cancer risk - Nature Communications

The impact of variants of uncertain significance (VUS) on protein function and cancer risk remain unclear. Here, the authors focus on the functional impact of VUS of the PALB2 gene and identify defect...

nature.com

Verry happy and thankful that the Dutch Cancer Society (KWF)/Alpe d'Huzes has decided to fund our research. We aim to determine how disabling Fanconi anemia proteins can kill BRCA1-deficient cancer, paving the the way for a new personalized treatment for BRCA1-patients. www.kwf.nl/nieuws/toeke...

Ruim 32 miljoen voor nieuw kankeronderzoek

Dankzij onze donateurs starten ruim 50 nieuwe onderzoeken om de impact van kanker te verkleinen.

kwf.nl

Great response so far for the DNA Repair Meeting in April 2026 ! 🧬 A few poster spots are still available. ✨ Early-bird registration extended to February 28th ✨ New invited speakers added: check the site: dnarepairmeeting-egmond2026.com Don’t miss this outstanding meeting!

Registration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗 dnarepairmeeting-egmond2026.com

A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com

We present Repli-ID, an approach to identify proteins affecting DNA replication. Lge1 and Rox1 are new regulators of this process. Great work by @sophievdhorst.bsky.social, @lleonie.bsky.social and co-authors in collaboration with @andreichabes.bsky.social. tinyurl.com/mvvcp3xe

Replication-IDentifier links epigenetic and metabolic pathways to the replication stress response - Nature Communications

Cells activate various pathways to counter DNA replication stress. Using Replication-IDentifier (Repli-ID), the authors identified 423 genes, including LGE1 and ROX1, linking epigenetic and metabolic ...

tinyurl.com

Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond Registration will open by June 2025.

Deadline approaching for the EMBO workshop "Chromatin dynamics and nuclear organisation in genome maintenance", June 17-20, 2024, Leiden, the Netherlands. Speaker slots available! Register before April 1, 2024! meetings.embo.org/event/24-chr...

The EMBO workshop "Chromatin dynamics and nuclear organisation in genome maintenance" will take place from June 17-20, 2024, in Leiden, the Netherlands. Check our fantastic list of speakers and register before April 1, 2024, at meetings.embo.org/event/24-chr.... Speaker slots available!

We are searching for a highly-motivated postdoc to study a newly-identified DNA repair protein, ZNF384, using state of the art functional genomics and biochemistry approaches. Interested in joining vanattikumlab.org? Apply via the link below: tinyurl.com/hedwn8nx