Luijsterburglab
@luijsterburglab.bsky.social
The Luijsterburg lab at the LUMC in Leiden investigates DNA repair mechanisms during gene transcription | luijsterburglab.org
New preprint from the lab on mechanisms of KIF18A inhibitor resistance, led by @sjklaasen.bsky.social in collaboration with @ivatolic.bsky.social and @haicovanattikum.bsky.social biorxiv.org/content/10.648…
Happy that our most recent paper on nucleotide excision repair mechanisms has now been published in Science Advances. This project was led by @natalia-mg.bsky.social and @callumhaste.bsky.social and focused on visualising early steps of the NER process by #cryoEM. www.science.org/doi/10.1126/...
Visualization of stepwise derepression of TFIIH in global genome nucleotide excision repair
Cryogenic electron microscopy captures nucleotide excision repair complexes assembling on damaged DNA templates.
science.org
My inaugural lecture on July 6 was an unforgettable occasion, made so special by the presence of family, friends, colleagues, and my amazing lab members, past, present, and perhaps future. I am deeply grateful to everyone who joined and helped make the day so memorable. hdl.handle.net/1887/4307045
Another great science appointment is coming up with @labvincenzo.bsky.social and @luijsterburglab.bsky.social! 🧬 🗓️ Join us live on Tuesday, June 9th at 5pm (Rome) / 11am (NYC). 📍 Zoom link: uzh.zoom.us/j/6598481621... 📥 Register here to stay in the loop: docs.google.com/forms/d/e/1F...
Are transcription-associated histone marks needed to restart transcription after DNA damage? We put this long-standing assumption to the test. With surprising results. Work with Janne van Schie, Bram de Groot & Diana van den Heuvel out in EMBO Reports 👇 link.springer.com/article/10.1...
Registration is now open for the 2026 Gordon Research Conference on Mutagenesis 🧬 📍 Waterville Valley, NH 📅 June 21–26 Theme: Next-Generation Views on Mutation Mechanisms and Their Impact 🎤 Short talks selected from abstracts 👉 www.grc.org/mutagenesis-...
Excited to share our latest study in Nature Communications ✨ We map how cells clear DNA damage–stalled RNA polymerase II using a stepwise TFIIH → ubiquitin/VCP mechanism, keeping transcription and genome stability on track. Paper: www.nature.com/articles/s41... #Genomics #DNADamage #CellBiology
Our great collaboration with the lab of Wei Yang and Kaoru Sugasawa is now online in Nature. We’re glad we could contribute some cell biology to complement this beautiful structural and biochemical work. www.nature.com/articles/s41...
Pre-incision structures reveal principles of DNA nucleotide excision repair - Nature
Cryo-electron microscopy structures of nucleotide excision repair complexes reveal the roles of the constituent proteins XPA, XPB, XPC, XPD, XPF, XPG and RPA in DNA bubble formation and excision ...
nature.com
This meeting comes highly recommended! Register soon!
Luijsterburglab@luijsterburglab.bsky.social · 8mo agoGreat response so far for the DNA Repair Meeting in April 2026 ! 🧬 A few poster spots are still available. ✨ Early-bird registration extended to February 28th ✨ New invited speakers added: check the site: dnarepairmeeting-egmond2026.com Don’t miss this outstanding meeting!
Great response so far for the DNA Repair Meeting in April 2026 ! 🧬 A few poster spots are still available. ✨ Early-bird registration extended to February 28th ✨ New invited speakers added: check the site: dnarepairmeeting-egmond2026.com Don’t miss this outstanding meeting!
Excited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...
📣 Early-bird deadline approaching! 🧬 Register now for the DNA Repair Meeting in Egmond aan Zee • Apr 19–24, 2026 ⏳ Early-bird & abstract deadline: Jan 10, 2026 🔗 Program & registration: dnarepairmeeting-egmond2026.com Included: • 5-night stay • All meals • Full program See you there! 🌊
Luijsterburglab@luijsterburglab.bsky.social · 10mo agoRegistration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗 dnarepairmeeting-egmond2026.com
To all DNA repair aficionados 🧬 who want to attend the Egmond Repair Meeting in April 2026: The deadline for early registration is January 10th, 2026! 🗓️ Sign up soon to benefit from the early-bird registration fee 🐦💸 See you all in Egmond! 🌊✨
Luijsterburglab@luijsterburglab.bsky.social · 10mo agoRegistration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗 dnarepairmeeting-egmond2026.com
Our protocol for imaging-based quantification of RNAPII clearance during transcription-coupled DNA repair is now online. 👇 Well done, Bram, Diana, and Paula! star-protocols.cell.com/protocols/45...
Cell Press: STAR Protocols
STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all are...
star-protocols.cell.com
Registration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗 dnarepairmeeting-egmond2026.com
New paper alert! 🚨 We report two Cypriot XP-A patients with a mild phenotype caused by the homozygous c.389G>A (p.R130K) variant. 👉 The variant affects splicing, leading to reduced XPA mRNA/protein but residual NER activity. www.sciencedirect.com/science/arti...
📢 ERCC1-hepatorenal syndrome is defined as a severe, multisystem DNA repair disorder associated with high morbidity and mortality, including an elevated cancer risk. 🧬 @luijsterburglab.bsky.social www.nature.com/articles/s41...
A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines - European Journal of Human Genetics
European Journal of Human Genetics - A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines
nature.com
Dive into the step-by-step choreography of transcription-coupled DNA repair. In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research! www.nature.com/articles/s41...
The molecular basis of human transcription-coupled DNA repair - Nature Cell Biology
This Review discusses transcription-coupled DNA repair in response to the stalling of RNA polymerase II on different types of DNA lesions and highlights the molecular details for the different steps i...
nature.com
Happy to share I have been promoted to Full Professor of Transcription and DNA Repair! Huge thanks to all current and former Luijsterburg Lab members. Your hard work, dedication, and inspiring spirit made this possible! 💥🧬🙏 www.luijsterburglab.org
Are transcription-associated histone marks involved in restoring transcription after DNA damage in human cells? Read the surprising outcome in our new preprint 👇 www.biorxiv.org/content/10.1...
Very proud of this international collaborative team effort published in EJHG defining ERCC1-hepatorenal syndrome as a severe multisystem DNA repair disorder with high mortality and pediatric liver cancer risk. Thanks to all families and collaborators. www.nature.com/articles/s41...
A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines - European Journal of Human Genetics
European Journal of Human Genetics - A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines
nature.com
📢 Only 2 more days left until the early bird registration deadline! Secure your spot and join us at the 8th EU-US Conference on Endogenous DNA Damage and Repair!
A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com
It was wonderful to have our lab symposium yesterday, filled with great science, new ideas, good company, and delicious food. What a pleasure it is to work with such a fantastic group of people!
Our letter-to-the-editor providing evidence that ARK2N is not a core factor in transcription-coupled DNA repair is now online in PNAS | www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond Registration will open by June 2025/
