“Bioluminescence temporal signatures of monocyte differentiation reveals changes in phenotype due to GM-CSF, M-CSF, and PMA induction,” by Zachary James et al. Learn more: https://www.sciencedirect.com/science/article/pii/S0301468126000472

Sakshi Nalkande et al. present a comprehensive review of evidence from contemporary literature establishing ovarian fibrosis as a critical and increasingly unrecognized pathological manifestation of polycystic ovary syndrome: https://www.sciencedirect.com/science/article/pii/S0301468126000460 #PCOS

Tannaz Sakhavarz et al. provide the first comprehensive evidence that Palmatine functions as a potent, multi-level osteo-inductive molecule in human adipose-derived mesenchymal stem cells. Learn more: https://www.sciencedirect.com/science/article/pii/S0301468126000459

It’s not too late! Submit your research on splicing in development and disease to the Differentiation special issue led by Guest Editors Natoya Peart and Karine Choquet by June 30, 2026: https://www.sciencedirect.com/special-issue/322731/splicing-in-development-and-disease

Article from the "Splicing in Development and Disease" special issue: Evan C. Brooks, Charles W. Griffin, and Katherine A. Fantauzzo review the roles of RNA-bidning protein SRSF3 in development and cellular differentiation across a range of organisms: https://doi.org/10.1016/j.diff.2026.100958

“NNMT as a therapeutic target in fibrosis: Insights from the heart, liver, kidneys, and lungs,” by Shi-Yan Lai et al. Learn more: https://doi.org/10.1016/j.diff.2026.100959

Preethi Dharmendhran et al. provide a systemic review of current protocols for differentiating human pluripotent stem cells and human adipose-derived stem cells into brown adipocytes, assessing methodological consistency, differentiation outcomes, and key limitations: https://bit.ly/427qXHt

Findings from D. C. Andia et al. demonstrate that low and high osteogenic potential of periodontal ligament-derived mesenchymal stem cells correlates with RUNX2, SP7, EZH2 and KDM6B expression. Read the open access article to learn more: https://doi.org/10.1016/j.diff.2026.100944

Federica Quacquarelli et al. highlight the relevance of ex vivo human cellular models to examine paracrine interactions between osteoblasts and adipocytes and confirmed the role played by adipocyte-secreted factors in osteoblast transdifferentiation: https://doi.org/10.1016/j.diff.2026.100947

“Comprehensive defect detection in mouse embryos and the heart by combining automated phenotyping with novel population averages and atlases,” by Ella M. M. A. Martin et al. Read the open access article to learn more: https://doi.org/10.1016/j.diff.2026.100936

Cagney E. Coomer et al. found Her9 is required for the migration, differentiation, and survival of neural crest cells. Learn more: https://doi.org/10.1016/j.diff.2026.100935

Explore the special collection of papers on osteo biology—highlighting research and reviews from differentiation to regeneration—curated by Editors-in-Chief Loydie Jerome-Majewska, Crystal Rogers, and Rosa Uribe: https://www.sciencedirect.com/special-issue/10DXVD79TL0

Jessica Cristina Marín-Llera et al. explored the role of CEK8 (Ephrin-A4) in early tendon differentiation in the chicken limb and its interaction with WNT/β-catenin and TGF-β pathways during tendon blastema formation. Learn more: https://doi.org/10.1016/j.diff.2026.100932

Advance research in cell differentiation, stem cells, and cancer biology. Join ISD and connect with a global community of researchers shaping the future of developmental biology. Learn more: https://bit.ly/3P4feq2 #joinISD #ISDmembership

“Development and proteome characterization of a new muscle cell line from Oreochromis niloticus (Linnaeus, 1758),” by Vijay Lakshmi Sahoo et al. Learn more: https://doi.org/10.1016/j.diff.2026.100934

Deadline extended: Submit your research on splicing in development and disease to the Differentiation special issue led by Guest Editors Natoya Peart and Karine Choquet by June 30, 2026. Learn more: https://www.sciencedirect.com/special-issue/322731/splicing-in-development-and-disease

Findings from Chuanqing Mao et al. suggest that vismodegib disrupts TMJ development by inhibiting the Ihh-PTHrP signaling pathway, thereby altering angiogenesis in the condyle and ultimately impairing cartilage growth and structural integrity. Learn more: https://doi.org/10.1016/j.diff.2026.100933

Take your research abroad with support from ISD! Apply for a 2026 ISD Researcher Travel Award and receive up to $1,000 toward travel and registration. The deadline for Round 1 applications is approaching. Submit your application by Feb 28: https://bit.ly/4gp0go3 #isdfunding

Are you ready to share your science with the world? ISD Travel Awards provide financial support to help members present their work in cell and developmental biology at major scientific meetings. Apply now to expand your reach: https://bit.ly/4gp0go3 The deadline is Feb 28.

“Odd-skipped family members have conserved roles in segmentation, appendage, excretory system and gut development in bilaterian animals,” by Vasikar Murugapoopathy et al. Read the open access Perspectives article in Differentiation: https://doi.org/10.1016/j.diff.2025.100930

Review article: Siti Nurnasihah Md Hashim et al. explored how chemical and mechanical microenvironments cooperate to guide epithelial commitment across both conventional 2D and advanced 3D culture models. Learn more: https://doi.org/10.1016/j.diff.2026.100931

New to Differentiation: Explore the curated collection of 11 articles highlighting the latest key advancements and discoveries in osteo biology—from 2023 to present: https://www.sciencedirect.com/special-issue/10DXVD79TL0

Parth Aphale, Himanshu Shekhar, and Shashank Dokania provide a critical appraisal of “Osteocyte-like differentiation of osteosarcoma by inorganic phosphate,” by Suzuki et al. (Differentiation, 2025, 146:100912). Read the letter to the editor to learn more: https://doi.org/10.1016/j.diff.2025.100915

Deadline approaching: Submit to the forthcoming Differentiation special issue, “Splicing in Development and Disease,” by December 30, 2025! Learn more about the scope, guest editors, and benefits of publishing in a special issue: https://bit.ly/4o6TAxW

“fam20b-dependent proteoglycans do not affect dermal bone formation and fin regeneration, but Bmp signalling promotes fin regenerate outgrowth,” by Elham Koosha et al. Read the open access article in Differentiation to learn more: https://doi.org/10.1016/j.diff.2025.100914

Thank you, everyone, who joined the latest “Biological Differentiation Across the Scales” virtual seminar last week with Pavani P. Perera from Misty Riddle’s lab at @unevadareno.bsky.social. Couldn’t attend the live seminar? The recording is now available online! Watch now: https://bit.ly/4oIeT9k 🐟

TOMORROW: Join the Editors-in-Chief of Differentiation at 12:00 p.m. Central for a free virtual seminar with Pavani P. Perera. Registration closes 30 minutes before the event: https://bit.ly/4oaU71P Article: https://bit.ly/478UZhu

Please join us on Friday November 14th for: Differentiation Across Scales, "Enteric neural crest development in Astyanax mexicanus surface fish and cavefish.” Our presenter will be Pavani Ponnimbaduge Perera from Misty Riddle’s lab. It’s free to register! my.isdifferentiation.org/ISD/Events/E...

Differentiation Journal@diffjournal.bsky.social · 9mo ago

One week left to register! Join the Editors-in-Chief of Differentiation on November 14 at 12:00 p.m. Central for a virtual seminar with Pavani P. Perera on the enteric nervous system, evolution, and cave fish. Register for free: https://bit.ly/4oaU71P Topic: https://bit.ly/478UZhu

Mirco Galiè summarizes studies that support the hypothesis that the partially or fully mesenchymal phenotype might represent a general paradigm of stem cell plasticity underlying embryonic development, regenerative potential, as well as their pathological counterparts: https://bit.ly/3JADAW0

Interested in development? Cave fish? Enteric nervous system? Pretty pictures? Please join us next Friday! We are looking forward to the talk! 🤩

Differentiation Journal@diffjournal.bsky.social · 9mo ago

One week left to register! Join the Editors-in-Chief of Differentiation on November 14 at 12:00 p.m. Central for a virtual seminar with Pavani P. Perera on the enteric nervous system, evolution, and cave fish. Register for free: https://bit.ly/4oaU71P Topic: https://bit.ly/478UZhu