#Glioblastoma cells don’t just grow — they extend tumor microtubes that let them invade the brain 🧠 and link into multicellular networks that resist therapy ☢️. We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️. This study is now online @Cancer Discovery
Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression
Abstract. Glioblastomas are incurable primary brain tumors that depend on neural-like cellular processes, tumor microtubes (TMs), to invade the brain. TMs also interconnect single tumor cells to a com...
aacrjournals.org
Winkler Laboratory@winklerlab.bsky.social · 10mo agoHow to disconnect therapy-resistant tumor networks in glioblastoma? In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy. doi.org/10.1158/2159...