CASPASE‑8 supports T cell survival through mechanisms beyond repressing RIPK1‑dependent necroptosis. Conditional deletion studies reveal its essential role in CD8⁺ T cell maintenance and NKT cell development. Read more: vist.ly/5dp8w

How does BCG vaccination affect NK cells? This study found increased NK cell frequency in draining lymph nodes following vaccination, with no significant changes in their spatial organisation. 🔗 vist.ly/5cybd

New open‑access study by Maria Z. Krauss et al. shows how amino acid uptake and mTOR signalling in CD4⁺ T cells power immunity to Trichuris muris. SLC7A5 proves essential, and loss of mTOR leads to chronic infection. 🔗vist.ly/5cvng

🐖 New research shows pigs generate both strain-specific and broadly reactive influenza antibodies, including stem-targeting mAbs with cross-subtype recognition. A valuable tool for understanding influenza immunity and improving vaccine design. 📖 vist.ly/5ck5w

💊🧫 Antibiotics can do more than kill bacteria. This study shows that the fluoroquinolone levofloxacin directly alters macrophage biology, driving mitochondrial hyperpolarization and modulating iNOS expression in specific monocyte-derived macrophage populations. 📖 vist.ly/5c7t7

Fluoroquinolones directly drive mitochondrial hyperpolarization and modulate iNOS expression in monocyte-derived macrophage populations

AbstractIntroduction. The fluoroquinolone levofloxacin is often selected for use prophylactically as well as during respiratory infections. However, studie

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🧬 Innate lymphoid cells are emerging as key players in cancer immunity. This review explores the diversity, plasticity, and anti-tumour functions of type 1 innate lymphoid cells (ILC1s), with a focus on the immune checkpoint receptor PD-1. 📖 vist.ly/5c3ub #Immunology

🦠 Our epithelial barriers are home to complex interactions between T cells and the microbiota. This review explores how bacterial communities at the skin and intestinal surfaces shape T-cell function, balancing host defence, tolerance, and tissue repair. 📖 vist.ly/5bwzb

How do human ILCs adapt to lung niches? Single‑cell profiling shows distinct vascular vs. tissue programs and a shared extravascular “tissue signature” with NK cells. Read here: vist.ly/5bip9

Weinstein et al. measured 18 immunological traits in 581 wild bighorn sheep and found significant variation at both individual and metapopulation scales. A valuable new toolkit for wildlife health, disease ecology, and conservation research. 🐑 📖 vist.ly/5ba5u

Out of the shed and into the field: an immune toolkit for measuring wild ungulate immune phenotypes at multiple scales

Here we demonstrate the utility of our field-tested “immune toolkit” in describing the immune phenotypic heterogeneity of bighorn sheep (Ovis Canadensis) a

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High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions. A look into avian antibody evolution: vist.ly/5b78n

CCR2− Tph-like cells may help orchestrate local immune niches in human tumors, balancing immune activation and suppression. A promising new player in tumor immunity and immunotherapy response. 🔬 vist.ly/5an36

🧬 New research shows lung basal cell–derived PROS1 reduces COVID‑19‑induced inflammation and enhances antigen presentation in monocytes. Read the study: vist.ly/5adqg #COVID19Research #Immunology

Lymphoid stromal cells actively shape immune responses, not just tissue architecture. New research shows they directly sense TLR signals, increasing ICAM-1/VCAM-1 expression and secreting inflammatory mediators. 📖 vist.ly/59xt5 #Immunology

CASPASE‑8 plays a crucial role in T cell survival via mechanisms that extend beyond inhibiting RIPK1-dependent necroptosis. Conditional deletion analyses highlight its vital function in the maintenance of CD8⁺ T cells and the development of NKT cells. Read more: vist.ly/59ur8

Wild mice show large, robust T‑cell receptor repertoires that stay broad across age and sex, while older mice develop more dominant clones, likely from lifelong pathogen exposure. A fascinating look at how immunity adapts in natural environments. vist.ly/59qu4

A linear Doggybone™ DNA influenza vaccine induced immune responses to both HA and NA without interference, supporting NA inclusion to broaden protection and improve resilience to HA mismatch. 📖 vist.ly/595zv #Vaccines #Influenza #DNAVaccines

Optimizing a linear ‘Doggybone’ DNA vaccine for influenza virus through the incorporation of DNA targeting sequences and neuraminidase antigen

Abstract. Influenza virus represents a challenge for traditional vaccine approaches due to its seasonal changes and potential for zoonotic transmission. Nu

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🔬 PD-1 may help prevent autoimmunity triggered by mutation-derived neoantigens. New mouse data sheds light on immune-related adverse events seen with PD-1 blockade. vist.ly/593e2

Obesity disrupts dendritic cell responses to viral infection, reducing cytokine production and altering cellular metabolism in a mouse model. 📖 vist.ly/58wx2 #Immunology #Obesity #ViralInfection #DendriticCells

Obesity drives dysregulation in DC responses to viral infection

AbstractIntroduction. Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of

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Discover the benefits available when peer reviewing for the @britsocimm.bsky.social journals, including a chance to work with immunology experts to advance research. 🔗 oxford.ly/4fWq6kZ #ImmunoSky | @ceijournal.bsky.social | @imtadvances.bsky.social | @discovimmunol.bsky.social

🧬 Neutrophils are more adaptable than we thought. This research shows different cytokines trigger distinct gene expression programmes, influencing immune regulation, inflammation and interactions with T cells. 🔗 vist.ly/588kp #Immunology #Neutrophils

Cytokine-induced transcriptional changes in human neutrophils reveal immune regulatory plasticity

AbstractIntroduction. Neutrophils are innate immune cells that play a central role in the inflammatory response. They produce an array of destructive molec

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PD-1 loss + increased mutagenesis triggers liver granulomatous inflammation in mice, supporting a key role for PD-1 in preventing immune responses to neoantigens, relevant to toxicity seen with checkpoint blockade. 🔬 vist.ly/584be #Immunology

Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by de novo genome mutagenesis

AbstractIntroduction. Programmed death-1 (PD-1) is a negative regulator of immune responses. Upon deletion of PD-1 in mice, symptoms of autoimmunity develo

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Fluoroquinolones aren’t just antimicrobial, they shape immunity too. Levofloxacin drives mitochondrial hyperpolarization and selectively boosts iNOS in developing macrophages, highlighting stage-specific immune modulation. vist.ly/57yd5

Fluoroquinolones directly drive mitochondrial hyperpolarization and modulate iNOS expression in monocyte-derived macrophage populations

AbstractIntroduction. The fluoroquinolone levofloxacin is often selected for use prophylactically as well as during respiratory infections. However, studie

doi.org

🧬 New insights into Treg biology! This study uncovers how periodic TCR signaling shapes self-reactive T cells and how HTLV-1 hijacks these pathways. A new 2-axis model links activation dynamics to Foxp3 regulation, opening doors for cancer & immunotherapy research. #Immunology #Tcells

CARKL emerges as a key regulator of T-cell function by driving metabolic reprogramming, shaping cytokine output, mitochondrial activity, and migration via CXCR3. A compelling link between immunometabolism and immune regulation. vist.ly/57crf #Immunology #TCells #Immunometabolism

The sedoheptulose kinase CARKL controls T-cell cytokine outputs and migration by promoting metabolic reprogramming

AbstractBackground. Immunometabolism is a crucial determinant of immune cell function, influencing cellular activation and differentiation through metaboli

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PROS1 released by lung basal cells may help limit severe COVID‑19 inflammation and promote tissue repair, according to a Discovery Immunology study. 🧬 vist.ly/5792z #COVID19 #Immunology

PROS1 released by lung basal cells limits inflammation in epithelial and monocytes during SARS-CoV-2 infection

1. SARS-CoV-2 infection of the epithelium results in the release of IFN. 2. IFN secretion has an autocrine effect on epithelial cells. 3. Infection and IFN

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T cell activation depends on rapid gene expression changes. This study shows RAM is upregulated during activation and is essential for RNA cap formation, driving protein synthesis and CD4 T cell proliferation. 🔗 vist.ly/56rbp #Immunology #TCells

γδ T cells in the female reproductive tract, quiet defenders or active players in pregnancy? 🤔 This review unpacks their dynamic, hormone-responsive roles at this unique barrier site ⚖️ Part of our T Cells at Barrier Sites collection🧬 vist.ly/56m3b

Gamma delta (γδ) T cells in the female reproductive tract: active participants or indifferent bystanders in reproductive success?

Summary. The female reproductive tract accommodates and balances the unique immunological challenges of protection from sexually transmitted pathogens and

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Abatacept suppresses T cell activation, but how durable is its effect? Research shows its inhibitory impact is short-lived in vivo, diminishing significantly once treatment stops 🧬 🔗 vist.ly/55mmj #Immunology #Tcells #Autoimmunity

The effect of abatacept on T-cell activation is not long-lived in vivo

Abstract. Abatacept, a co-stimulatory blocker comprising the extracellular portion of human CTLA-4 linked to the Fc region of IgG1, is approved for the tre

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Pathogenic CD4⁺ T cells in experimental uveitis share key features with those seen across immune-mediated inflammatory diseases, highlighting common pathways driving chronic inflammation 🧬 🔗 vist.ly/55ib7 #Immunology #Autoimmunity #Tcells

A pathogenic CD4 T cell phenotype in experimental uveitis shares common features with other immune mediated inflammatory diseases

AbstractIntroduction. Murine ocular autoimmunity develops through 3 stages; prodrome, primary peak and secondary regulation. During the prodromal phase, le

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📢 New in Discovery Immunology New open-access research shows a strikingly shared (“public”) antibody response following PRV vaccination and challenge, revealed through porcine BCR repertoire profiling 🧬 🔗 vist.ly/54z8t #Immunology #Vaccines #Bcells #OpenAccess

Pseudorabies Study Overview

AbstractIntroduction. The antibody repertoire reflects the immune history of an individual. In the present study, we characterised the porcine antibody hea

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