Greffe de moelle osseuse : quand le nouveau système immunitaire s'emballe

Après une greffe de moelle osseuse, 6 patients sur 10 développent la maladie du greffon contre l'hôte. Le seul traitement possible, les corticoïdes, échoue dans la moitié des cas. Une étude révèle que...

radiofrance.fr

Corticosteroid resistance is predetermined by early immune response dynamics at acute graft-versus-host disease onset

Steroid-resistant acute graft-versus-host disease is set at disease onset and leads to distinct cell-to-cell cross-talk and immune trajectories.

science.org

A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology

Multiplexed imaging of aGVHD GI biopsies revealed epithelial remodeling and alteration in immune composition, offering insight into disease pathology.

science.org

Gut microbiota–derived TMAVA is a modulator of acute CNS-GVHD

In this study, we report that microbiota depletion exacerbates acute graft-versus-host disease in the central nervous system, driven by microglial activati

doi.org

Diet outperforms microbial transplant to drive microbiome recovery in mice - Nature

Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions th...

nature.com

Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey

Bone Marrow Transplantation - Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey

rdcu.be

Efficacy and safety of belumosudil for treatment of cGVHD: multicenter retrospective analysis of the French cohort of the compassionate use program, on behalf of the French Society of Bone Marrow Transplantation and Cellular Therapy

Bone Marrow Transplantation - Efficacy and safety of belumosudil for treatment of cGVHD: multicenter retrospective analysis of the French cohort of the compassionate use program, on behalf of the...

rdcu.be

HLA evolutionary divergence score after donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation

Donor lymphocyte infusion (DLI) prevents acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) relapses following hematopoietic stem cell transplantation. Given the life-threatening toxiciti....

doi.org

Systems-level immunomonitoring in children with solid tumors to enable precision medicine

In a population-based cohort of 191 children with diverse solid tumors, systems-level analyses unravel immune variation with age and tumor type and provide a reference for future precision immunothera...

cell.com