30% of our proteome is disordered, yet we still don't have reliable ways to predict functional implications of mutations in disordered regions, or drug them. Here's the latest on chromatin, condensates, and cancer from my group in Discovery Onc at Genentech journals.biologists.com/jcs/article/...

Decoding intrinsically disordered regions in chromatin dysfunction and cancer

Summary: This Perspective describes cancer variants that rewire chromatin regulation through intrinsically disordered regions (IDRs) and argues for comprehensive mapping of condensate-related nuclear ...

journals.biologists.com

I'm hiring a summer intern! Pursuing a PhD and interested in industry experience? Apply at the link below by Jan 26 to spend 12 weeks onsite at South San Francisco with Genentech's Discovery Oncology department in May-July 2026 pursuing novel therapies targeting disordered protein regions.

Chuffed to be recognized with an Early Career Award for work on the chromatin-nucleated phase separation of BRD4. ✨ Give it a read! www.molbiolcell.org/doi/full/10.... Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social And huge thank you @ascbiology.bsky.social

Interplay of condensation and chromatin binding underlies BRD4 targeting | Molecular Biology of the Cell

Nuclear compartments form via biomolecular phase separation, mediated through multivalent properties of biomolecules concentrated within condensates. Certain compartments are associated with specific ...

molbiolcell.org

Getting Strom Lab set up!

First day at my new job! I'm a Lab Head, Principal Scientist in Discovery Oncology at Genentech. I'll be searching for new targets to develop cancer treatments. 2nd photo is my newest friend on campus, decoy-ote. @genentech.bsky.social

The latest in my favorite love triangle: Chromatin <-(💜)-> Condensates <-(💚)-> Mechanics

@brangwynnelab.bsky.social · last yr.

Congrats to Jing @jesszhiyuezhao.bsky.social‬ & @dnamystrom.bsky.social‬ on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR

Cancelling grants that were already competitively won and awarded is the waste and abuse. www.nytimes.com/2025/07/10/u...

The Surprising Scientists Hit by Trump’s D.E.I. Cuts

nytimes.com

I'm thrilled to announce my next career step-- I’m joining Genentech as a Principal Scientist & Lab Head in Discovery Oncology! I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.

If heterochromatin is really a liquid-like condensate, why is it not spherical? We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments www.biorxiv.org/content/10.1...