Mehdi Bouhaddou
@doctorbou.bsky.social
The Molecular Thinking Lab @UCLA We apply systems biology to study the biochemical logic of post-translational mods and protein-protein interactions. 🦠 Virology, 🪸coral, and 🧫 cancer 🎰 Mass spec and 💾 bioinformatics 🌊 50% wet, 🌵50% dry 🏳️🌈 Welcome to all
What's larger, a protein or its templating mRNA ? > The mRNA is much larger. ⬛ 𝐀 𝐬𝐞𝐧𝐬𝐞 𝐨𝐟 𝐬𝐜𝐚𝐥𝐞 -- 𝐪𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐢𝐧𝐭𝐮𝐢𝐭𝐢𝐨𝐧 & 𝐜𝐨𝐧𝐬𝐭𝐫𝐚𝐢𝐧𝐭𝐬 -- 𝐢𝐬 𝐚 𝐩𝐨𝐰𝐞𝐫𝐟𝐮𝐥 𝐞𝐧𝐚𝐛𝐥𝐞𝐫 𝐨𝐟 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡. The figure shows myoglobin protein drawn to scale next to its mRNA template. The coding sequence of an mRNA ...
I'm honored to have received the 2025 HUPO Distinguished Service Award (hupo.org/HUPO-Awards-...) with @mlaval6.bsky.social for building a dynamic early career researcher (ECR) community within @hupo-org.bsky.social. Empowering and amplifying ECRs has been deeply meaningful to me—thank you, HUPO.
Thrilled to share the first major preprint from the lab. Viruses are classically viewed as targets of host sensing. Do viruses also sense and respond to the host? We propose viruses may act as “biosensors” of the host signaling state. A thread👇🏾 www.biorxiv.org/content/10.1...
Global Landscape of Human Kinase Motifs in Viral Proteomes
Viruses are classically viewed as targets of host sensing, yet whether they also sense and respond to host cues remains largely unexplored. We propose that host-driven post-translational modification ...
biorxiv.org
🔬New Preprint Alert 🔬 How is AMPK regulated by oxidative stress? We use functional imaging to uncover spatial regulation of AMPK activity during oxidative stress by LKB1 & CaMKK2. Combining imaging with proteomics & metabolomics, we find AMPK works to promote the cellular redox response.
bioRxiv Biochemistry@biorxiv-biochem.bsky.social · 9mo agoSpatial regulation of AMPK activity under oxidative stress requires LKB1 https://www.biorxiv.org/content/10.1101/2025.11.17.688926v1
Here's the letter that NSF sent UCLA last week about cutting its research funding NSF says UCLA is doing affirmative action by asking applicants' their zip codes, family income and what HS they went to, and that they can discuss race in personal statements storage.courtlistener.com/recap/gov.us...
If you are interested to learn about our work studying firefighter health in LA! We study how exposure to toxic chemicals alters phosphorylation signaling in lung cells to drive cancer. www.uclahealth.org/news/article...
Firefighters have a higher risk of cancer – but why?
UCLA researchers are working with the Los Angeles County fire department to test firefighting gear as a possible source of risk.
uclahealth.org