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Dr. Susan Winters ☕️

@docwinter.bsky.social

Cheese lover, guitarist, physician-scientist investigating the role of inflammatory bio-markers in MS, amateur barista

488 Posts1706 Follower247 Folgt
Dr. Susan Winters ☕️@docwinter.bsky.social · 2w ago

COVID and EBV aren’t always “one and done.” In susceptible people, they can rev up B cells that make autoantibodies, erode immune tolerance, and feed pathways seen in lupus, MS, and Long COVID. Reinfection isn’t harmless. Fewer infections = fewer chances to trigger that machinery.

Molecular Pathways Driving Autoantibody Production Following SARS-CoV-2 Infection Identified

Findings suggest that SARS-CoV-2 infection can activate an immune program that closely resembles those involved in established autoimmune disorders.

genengnews.com

Dr. Susan Winters ☕️@docwinter.bsky.social · last mo.

🚨 BREAKING 🚨 | COVID MAY WAKE THE VIRUSES SLEEPING INSIDE YOU In 1,154 hospitalized patients, researchers found dormant viruses like EBV and CMV reactivating, linked to worse COVID. One viral family was associated with long COVID

Virus reactivation in acute and long COVID-19 - Nature

Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune signatures with prog...

nature.com

Dr. Susan Winters ☕️@docwinter.bsky.social · 2mo ago

🚨 The 2026 ACC/AHA dyslipidemia guideline just made 21 MILLION more Americans eligible for statins, over HALF of adults 30-79! New age range, lower risk thresholds, CKD & HIV added. Yet NO new low-risk statin trials since 2018. Big implications ahead. 💊

Implications of the 2026 Dyslipidemia Guideline for Primary Prevention Statin Therapy

This cross-sectional study explores the 2026 guideline on dyslipidemia management, examining the population health impact on US adults recommended primary prevention statin therapy due to atherosclero...

jamanetwork.com

Dr. Susan Winters ☕️@docwinter.bsky.social · 3mo ago

Big COVID news: the FDA just approved Xocova (ensitrelvir), the first oral antiviral shown to help prevent symptomatic COVID-19 after exposure. In the Phase 3 SCORPIO-PEP trial, it reduced the risk of symptomatic infection by 67% when started within 72 hours of household exposure. #BlueSky #Covid19

Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts | NEJM

Ensitrelvir, an oral inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C-like protease, is approved in Japan for the treatment of mild-to-moderate coronavirus disease 2019 ...

nejm.org

Dr. Susan Winters ☕️@docwinter.bsky.social · 3mo ago

Big COVID news: the FDA just approved Xocova (ensitrelvir), the first oral antiviral shown to help prevent symptomatic COVID-19 after exposure. In the Phase 3 SCORPIO-PEP trial, it reduced the risk of symptomatic infection by 67% when started within 72 hours of household exposure. #BlueSky #Covid19

Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts | NEJM

Ensitrelvir, an oral inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C-like protease, is approved in Japan for the treatment of mild-to-moderate coronavirus disease 2019 ...

nejm.org

Dr. Susan Winters ☕️@docwinter.bsky.social · 4mo ago

🚨 COVID BREAKTHROUGH: For the first time, an antiviral pill cut post-exposure symptomatic COVID from ~9% to ~3% in household contacts. For transplant patients, care-home residents and high-risk families, this could be massive. #COVID #PublicHealth #Medicine #Science #Health

At last, a pill that can prevent COVID after exposure to infected people

Drug arrives years after pandemic’s peak, but could still offer protection to vulnerable populations.

nature.com

Dr. Susan Winters ☕️@docwinter.bsky.social · 4mo ago

🚨 COVID BREAKTHROUGH: For the first time, an antiviral pill cut post-exposure symptomatic COVID from ~9% to ~3% in household contacts. For transplant patients, care-home residents and high-risk families, this could be massive. #COVID #PublicHealth #Medicine #Science #Health

At last, a pill that can prevent COVID after exposure to infected people

Drug arrives years after pandemic’s peak, but could still offer protection to vulnerable populations.

nature.com

Dr. Susan Winters ☕️@docwinter.bsky.social · 5mo ago

BREAKING: New bat coronavirus discovered with a ready-made key to human lungs. Scientists say it is only a matter of time. The next pandemic may already be in the air. #Pandemic #Science #MedSky #Vaccines #Health #Bluesky

Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells - Nature

Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.

nature.com

Dr. Susan Winters ☕️@docwinter.bsky.social · 5mo ago

This is incredible. A simple vaccine during pregnancy cutting newborn hospitalizations from RSV by around 80% is exactly the kind of quiet breakthrough that changes lives. Protecting babies from day one is huge. Science at its best. #MedSky #Vaccines #Science #BlueSky

Pregnancy vaccine reduces baby hospital admissions for RSV by 80%

A study confirms the vaccine gives excellent protection for babies against life-threatening chest infections.

bbc.com

Dr. Susan Winters ☕️@docwinter.bsky.social · 6mo ago

We may have been counting COVID deaths wrong. A new study suggests many deaths labeled as heart disease or pneumonia were likely COVID, especially early on. Not a conspiracy. Just messy data. If the toll was higher than reported… what else are we sure about that isn’t true? #MedSky #Covid19

Applying machine learning to identify unrecognized COVID-19 deaths recorded as other causes of death in the United States

A machine learning approach suggests that COVID-19 deaths were undercounted unevenly across sociodemographic groups in 2020–2021.

science.org

Dr. Susan Winters ☕️@docwinter.bsky.social · 6mo ago

Exciting Nature study shows microbiome-driven gut inflammation disrupts vagus nerve signaling to the hippocampus, accelerating cognitive decline. In mice, restoring gut–brain signaling reversed memory loss. Happy to have new therapeutic targets to pursue! #AgingResearch #Longevity #MedSky

Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature

Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...

nature.com

Dr. Susan Winters ☕️@docwinter.bsky.social · 7mo ago

Flu: trashes your lungs, then leaves. COVID: trashes your lungs and quietly rewires your brain, with persistent inflammation, microvascular injury, and monoamine pathway disruption weeks after clearance. Stop calling that ‘the flu.’ #MedSky #Covid19

Frontiers | Characterization of subchronic lung and brain consequences caused by mouse-adapted SARS-CoV-2 and influenza A infection of C57BL6 mice

IntroductionSARS-CoV-2 and, to a lesser extent, influenza A can lead to long-term complications in the respiratory and nervous systems. However, the mechanis...

frontiersin.org

Dr. Susan Winters ☕️@docwinter.bsky.social · 7mo ago

A matched cohort study using OpenSAFELY data on 3.46M adults 50+ in England found the Autumn 2022 bivalent BA.1 mRNA boosters cut COVID hospitalisation and death risk by about half, with similar effectiveness for Pfizer and Moderna (waning over time)👊💉😀#MedSky #Vaccines #Covid19

Effectiveness of bivalent BA.1 mRNA booster vaccines during the autumn 2022 COVID-19 booster programme in adults aged 50+ in England: observational matched cohort study using OpenSAFELY

Estimate the effectiveness and comparative effectiveness of booster vaccination with bivalent original/omicron BA.1 mRNA-1273 (Moderna) and original/o…

sciencedirect.com

Dr. Susan Winters ☕️@docwinter.bsky.social · 8mo ago

Reminder as flu season clobbers everyone: 1 “nose-first” paper worth bookmarking 👇 Intranasal Neosporin paper: flips on nasal innate antiviral genes (ISGs) and reduced flu/SARS-CoV-2 in animals, with a small human pilot. Interesting signals, still waiting on human trials #Flu #BlueSky #MedSky

Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract

Respiratory virus infections in humans are a significant global health concern, causing a wide range of diseases with substantial morbidity and mortality worldwide. This underscores the urgent need for effective interventions to reduce the burden of ...

pmc.ncbi.nlm.nih.gov

Dr. Susan Winters ☕️@docwinter.bsky.social · 8mo ago

Aronia berry juice vs. a high-fat diet: in a humanized mouse model, a single daily shot of this polyphenol bomb helped preserve gut bugs, boost barrier-supporting metabolites, and temper metabolic fallout, especially when donors had a more inflamed microbiome #GutHealth #MedSky #NutritionScience

Frontiers | Metabolic impact of polyphenol-rich aronia fruit juice mediated by inflammation status of gut microbiome donors in humanized mouse model

Background: The Aronia melanocarpa fruit is emerging as a health food owing to its high polyphenolic content and associated antioxidant activity. Antioxidant...

frontiersin.org

Dr. Susan Winters ☕️@docwinter.bsky.social · 8mo ago

Aronia berry juice vs. a high-fat diet: in a humanized mouse model, a single daily shot of this polyphenol bomb helped preserve gut bugs, boost barrier-supporting metabolites, and temper metabolic fallout, especially when donors had a more inflamed microbiome #GutHealth #MedSky #NutritionScience

Frontiers | Metabolic impact of polyphenol-rich aronia fruit juice mediated by inflammation status of gut microbiome donors in humanized mouse model

Background: The Aronia melanocarpa fruit is emerging as a health food owing to its high polyphenolic content and associated antioxidant activity. Antioxidant...

frontiersin.org

Dr. Susan Winters ☕️@docwinter.bsky.social · 9mo ago

Stranger Things is fiction, but the Upside Down is built on real physics ideas like the many-worlds interpretation of quantum mechanics. Quantum events split reality into countless branches. No portals yet, but the math still works #StrangerThings #QuantumPhysics #SciComm #Science #Art

Are we living in a parallel universe? The strange physics of Stranger Things

Nature speaks to theoretical physicists to explore the real theories that inspired the hit series. Warning: contains spoilers.

nature.com