Released today: ~1.5 Tbp of ONT metagenomic sequencing from compost. Assembly, MAGs, and downstream analysis are available to play with epi2me.nanoporetech.com/compost_mgx_...
Metagenomic Assembly Sheds Light on Microbial Diversity in Compost
Overview We are pleased to release a metagenomic dataset from deep sequencing of a mature compost…
epi2me.nanoporetech.com
Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback. rdcu.be/famFj
High-resolution metagenome assembly for modern long reads with myloasm
Nature Biotechnology - A long-read metagenome assembly method recovers circular and complete genomes better than existing tools.
rdcu.be
Nature Biotechnology@natbiotech.nature.com · 4mo agoHigh-resolution metagenome assembly for modern long reads with myloasm - @lh3lh3.bsky.social @jimshaw.bsky.social @danafarber.bsky.social @harvardmed.bsky.social go.nature.com/3PBEwvR
New tool from Heng Li lab, offering amazing accuracy for SVs even in low complexity regions (also incredible SNPs/Indels for a deeplearning-free approach)
Long reads carry multiple small vars and SVs and their phasing. LongcallD is the only caller that tightly integrates germline/mosaic small/structural vars/MEIs and their phasing in a single C program. One command line to get competitive small variant calls and better SVs. Led by Yan Gao.
The most satisfying genome assembler to run, ever. Huge appreciation for the team behind hifiasm 👏
Efficient near-telomere-to-telomere assembly of nanopore simplex reads - Nature
A genome assembly method called hifiasm (ONT) allows the assembly of chromosomes from telomere to telomere without the need for ultra-long reads, and outperforms conventional methods on most evaluatio...
doi.org
We can’t wait to welcome you back to Old Billingsgate! Early bird tickets for London Calling 2026 are now available to purchase! Buy yours before 1st Jan and be a part of the biggest Oxford #Nanopore sequencing event of the year. Click here for tickets: https://bit.ly/4ouoqzR
plsRT: Looking for a motivated postdoc! Join us at @bcmhgsc.bsky.social to explore the mosaic & somatic landscape of the human genome: structural variants, methylation, and all things @smahtnetwrk.bsky.social If you like long reads, complex variants & methylation come talk to me!
Trio-barcoded @nanoporetech.com Adaptive Sampling (TBAS) to improve #RareDisease diagnostic at less than 1/2 the $$ & high cov: 76% solve rate across 13 trios inc. two corrections from prev. diagnosis. www.medrxiv.org/content/10.1... @gregor-research.bsky.social @bcmhgsc.bsky.social #Research
Happy to share that the paper describing Autocycler is now 100% up: doi.org/10.1093/bioi... (1/3)
Autocycler: long-read consensus assembly for bacterial genomes
AbstractMotivation. Long-read sequencing enables complete bacterial genome assemblies, but individual assemblers are imperfect and often produce sequence-l
doi.org
ONT has a temporary bioinformatics position (8 months) open while I'm on maternity leave. Focus will be on microbial genomics but with opportunities to work on projects across the breadth of genomics! ejnh.fa.em2.oraclecloud.com/hcmUI/Candid...
Applications Bioinformatician (8 month temporary role)
We are looking for an individual with expertise in bioinformatics and data analysis, specializing in microbial genomics and metagenomics, to join our Applications team as an Applications Bioinformatic...
ejnh.fa.em2.oraclecloud.com
Usually avoid politics on bluesky, but PBS is a particularly special cause for me: The House will vote this week on a massive cut to public media funding. Your local stations are at risk. Call your Rep. now and urge them to vote NO before it’s too late. bit.ly/3T68Qgw #ProtectMyPublicMedia
It's been a good month for Nanopore assembly preprints! This time metagenomic assembly with nanoMDBG: hundreds of high-quality MAGs from high-complexity communities
bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · last yr.High-quality metagenome assembly from nanopore reads with nanoMDBG https://www.biorxiv.org/content/10.1101/2025.04.22.649928v1
Exciting preprint from Haoyu Cheng (not on bluesky?) and @lh3lh3.bsky.social: building amazing Nanopore assemblies just got faster and more accessible! Thrilled to have played a small part in this work!
bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · last yr.Efficient near telomere-to-telomere assembly of Nanopore Simplex reads https://www.biorxiv.org/content/10.1101/2025.04.14.648685v1
Check out our new Apps Note on metagenomic assembly of the Zymo fecal reference with nanopore sequencing and metaMDBG. Almost 200 Gb of metagenomic sequence data from a single PromethION flowcell, yeilding hundreds of high-quality metagenome assembled genomes: nanoporetech.com/resource-cen...
Application note: Oxford Nanopore sequencing provides superior MAG recovery and strain-level resolution from a complex microbiome | Oxford Nanopore Technologies
In this application note, we demonstrate the capabilities of Oxford Nanopore metagenomics by sequencing and analysing the well-characterised ZymoBIOMICS Fecal Reference.
nanoporetech.com