David Doupe

@dpdoupe.bsky.social

Epithelial stem cell biologist, Durham UK

Why does tissue function decline in ageing? One reason is that the stem cells that maintain normal homeostasis become mis-regulated. In our latest preprint, we identify the transcription factor Sob as a key regulator of Drosophila intestinal stem cells and aging. www.biorxiv.org/content/10.6...

The Transcription Factor Sob Maintains Intestinal Stem Cell Homeostasis to Delay Ageing

Ageing is associated with physiological decline and disrupted tissue homeostasis, often driven by imbalanced stem cell activity. The Drosophila midgut serves as a powerful model for studying epithelia...

biorxiv.org

Another exciting PhD opportunity involving some collaborative fly stem cell work. This one is led by Ting-Yu Lin from the @cpbm-heddlelab.bsky.social and will use a range of biochemical and biophysical techniques to explore the function of a critical RNA modifier: www.findaphd.com/phds/project...

Understanding of RNA pseudouridylation and its impacts in disease at Durham University on FindAPhD.com

PhD Project - Understanding of RNA pseudouridylation and its impacts in disease at Durham University, listed on FindAPhD.com

findaphd.com

Today the Royal Society will meet to discuss “Fellows’ behaviour”. Without doubt the fellow they will primarily be discussing is Elon Musk. The behaviour may range from his public dissemination of unfounded conspiracy theories to his attacks on the science 🧵 1/38

We are recruiting for 2 possible PhD positions to start October 2024 focussing on different aspects of stem cell regulation using the Drosophila midgut as a model system.

Confocal microscope image of a Drosophila midgut showing expression of a stem cell marker.