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Dr J G Inglis

@drjginglis.bsky.social

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Dr J G Inglis@drjginglis.bsky.social · last yr.

🚨New preprint out! Here we explored how the nervous system modulates the common synaptic inputs to motor neurons during grasping vs less functionally relevant hand tasks. Especially honored to have collaborated with Prof. Fuglevand on this one. 🔗 doi.org/10.1101/2025...

Adaptations in common synaptic inputs to spinal motor neurons during grasping versus a less functional hand task

Previous evidence suggests that shared synaptic inputs across spinal motor neurons play a key role in coordinating multiple muscles during hand movements, reducing control complexity. In this study, w...

doi.org

Dr J G Inglis@drjginglis.bsky.social · last yr.

Call it a St Paddy’s Day miracle but it’s finally out on this special day. Very proud of this team effort. This also represents my first paper for my @MSCActions PDF as we also address short comings in the identification of MU behaviour in underrepresented populations. doi.org/10.1152/japp...

Motor unit discharge behaviour in human muscles throughout force gradation: a systematic-review and meta-analysis with meta-regression. | Journal of Applied Physiology | American Physiological Society

The analysis of motor unit (MU) discharge behaviour provides an effective way of assembling information about the generation and control of movement. In this systematic-review and meta-analysis we identified and summarized the literature investigating MU discharge rate and discharge rate variability (CoV-ISI) during voluntary isometric contractions at various force levels. Databases were searched up to January 7, 2025, and a total of 262 studies were included. The meta-means of MU discharge rate and CoV-ISI were estimated and compared across human muscles. The influence of contraction intensity on MU discharge behaviour was assessed through linear meta-regressions. At low-to-moderate forces (<60% MVC), the first dorsal interosseous, biceps brachii (BB) and forearm extensors (FE) had the highest discharge rate, while the soleus had the lowest. At high force levels (>60% MVC), the tibialis anterior (TA) had the highest mean discharge rate compared to all other muscles, with the soleus maintaining the lowest. Regarding CoV-ISI results at low forces (<30% MVC), the TA had the lowest CoV-ISI values, except in comparison to the vastii. Additionally, the vastii had lower CoV-ISI values than the FE, gastrocnemius medialis, and soleus. Contraction intensity was positively associated with the mean discharge rates in all muscles investigated, although some muscles showed steeper slopes than others. Similar results were observed for CoV-ISI meta-regressions, with muscle-specific differences in slope. These findings suggest potential variations in neural control strategies across muscles during force gradation, such as differences in the relative contribution of rate coding to facilitate increasing force demands.

doi.org

Dr J G Inglis@drjginglis.bsky.social · last yr.

🆕 New preprint out! Here we applied dimensionality reduction to examine the relationship between low-dimensional motor unit components and force during repetitive isometric tasks, as well as the consistency of these components across trials. Read more: doi.org/10.1101/2025...

A single low-dimensional neural component of motor unit activity explains force generation across repetitive isometric tasks

Previous studies suggest that low-dimensional control underlies motor unit activity, with low-frequency oscillations in common synaptic inputs serving as the primary determinant of muscle force produc...

doi.org

Greg Pearcey@gregorypearcey.bsky.social · 2y ago

Hats off to UG Honours student, Emma, for designing this year’s Motoneuron meeting logo, which we will host here in St. John’s from July 8-11. Abstract submissions to open in the next 24 hours 👀

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