Happy to have developed the theory here, linking sequence-dependent charge patterns to favourable electrostatic interactions between homologous dsDNA🧬🧬 Matching theory & expt suggests a physical basis for sequence recognition that may underpin aspects of recombination, DNA repair, and replication.
Di Michele Lab@dimichelelab1.bsky.social · 11mo agoIt turns out sDNA 🧬 interacts selectively! Andy Stannard measured these interactions very (very) precisely, and Ehud Haimov, @drjonhedley.bsky.social, Alexei Kornyshev worked out how it all works. It has to do with charge correlation... Check it out here chemrxiv.org/engage/chemr...