Rianne Lord

@drriannelord.bsky.social

UKRI FLF & Assoc. Prof. @ Uni of Warwick | Topic Editor for ACS Organomet | Advisory board for EurJIC | views are my own.

Nominations are open until 31st December for this year's Organometallics Distinguished Author Award. Please consider nominating an amazing early career researcher for this award! 🙏🏼🥳

Michael Hurst@chemhurst.bsky.social · 11mo ago

Know an amazing Organometallic chemist? Consider nominating them for the #Organometallics Distinguished Author Award! @pubs.acs.org Nominations are accepted until December 31, 2025 at organicdivision.org/ompaper/

Promotional graphic calling for nominations for the Organometallics Distinguished Author Award

October has been hectic and I am a little late, but a really warm welcome to our new group members. Eleanore (PhD) working on vanadium metallodrugs, and Andrea and Kulsoom (MChem's) working on iron metallodrugs 🥳👏🏼✨️ Thanks as always to Ben for all your help with them!! 🙏🏼

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Late to the party, but... Congratulations to the group on the latest @pubs.acs.org in Inorganic Chemistry! Thanks for your efforts Tam and Ben 🙏🏼 Thanks also to Dr Ceyda Acilan and her team for the continued collaboration 🙏🏼🎉🥂 pubs.acs.org/doi/10.1021/...

Understanding the Modes of Action of β-Ketoiminato Iridium(III) Complexes in Cancer Cells

Four new charged iridium(III) 1,2,3,4,5-pentamethylcyclopentadienyl (Cp*) complexes, 1–4, of the type [Cp*Ir(L1–4)(PTA)](PF6) (where L1–4 = functionalized β-ketoiminate ligands and PTA = 1,3,5-triaza-7-phosphaadamantane), have been successfully synthesized and characterized. Single crystal X-ray crystallographic data have been obtained for all compounds and confirm a typical pseudo-octahedral half-sandwich geometry. Cytotoxicity values have been determined against a range of cancerous and noncancerous cell lines and highlight high cytotoxicity and selectivity toward breast cancers. Among these compounds, the unfunctionalized β-ketoiminate Ir(III) complex (1) emerged as the most promising candidate, demonstrating activity that was comparable to or exceeded that of cisplatin, especially after 24 h against the triple-negative MDA-MB-231 cell line. Morphological and molecular analyses confirmed that 1 triggers apoptotic cell death, involving caspase activation and PARP cleavage, which is consistent with its DNA-damaging characteristics, highlighting the future anticancer potential of compound 1.

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Huge congratulations to my first PhD student Oliver, on passing his PhD with minor revisions! 🎉🥂 Many thanks to Dr Charlotte Willans and Dr Alice Johnson for conducting the viva 🙏🏼

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I am delighted to have been asked to be a Topic Editor for @acs.org Organometallics! I am looking forward to working with the other editors and handling your bioinorganic publications! Also, a plug for more bioinorganic researchers to get submitted!! 🙏🏼🎉

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