Super stoked to have had the opportunity to present my work on the evolution of some weird transport proteins!! Many thanks @microbiologysociety.org for inviting me and organising this superb conference 🦠🧬 #Microbio26 #MicroSky

Sheppard Lab@sheppardlab.bsky.social · 4mo ago

Duncan Sussfeld @dsussfeld.bsky.social talking about TRAP transporters and their evolution ! Find Duncan around to know more. #Microbio26 @microbiologysociety.org @ineosoxford.bsky.social @dsussfeld.bsky.social

I’ve spent a lot of time over the past two years thinking about genome evolution and how recent research revealing complex gene-gene interactions has complicated traditional ‘gene-centric’ genomic approaches to evolution. So here is a review that consolidates these thoughts! rdcu.be/e6pHY

Epistasis and co-adaptation in bacterial genome evolution

Nature Reviews Genetics - Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic...

rdcu.be

THANKYOU to our amazing #PAG33 OneHealth Hologenomics speakers @keyfm.bsky.social @dsussfeld.bsky.social @annakovalenko.bsky.social @akang3705.bsky.social Kristina Kordova & Anders Götherström! Ancient plague & parvovirus! AMR genes! Bat ectoparasite microbiomes! & the clap is thriving in the USA! 🎉

📣 Keynote speaker announced Prof David Kelly @sheffielduni.bsky.social will join us at #CampyUK2025 to discuss "Campylobacter and Oxygen: A Double-Edged Sword." 24/25th Sep, register now! campyuk.web.ox.ac.uk/speakers#col... @biology.ox.ac.uk @microbiologysociety.org @ineosoxford.bsky.social

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📣 The deadline for abstract submission and early bird registration has been extended to 7th August. Registration fees will increase after this date! Visit campyuk.web.ox.ac.uk/home to secure your place! #microsky @biology.ox.ac.uk @microbiologysociety.org @ineosoxford.bsky.social

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🚨New pre-print 🚨 We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n www.biorxiv.org/content/10.1...

Genome co-adaptation and the evolution of methicillin resistant Staphylococcus aureus (MRSA)

Background: Antimicrobial resistance (AMR) in bacterial pathogens is a major threat to global health, rendering standard treatments ineffective and increasing the risk of severe infection or death. Re...

biorxiv.org

📣 So excited to share the latest paper from my PhD with @aire-team.bsky.social, out now in Environmental Microbiome! 🥳 We mined a large ocean microbiome for remote homologues of core gene families in uncultured lineages. Key points below ⤵️ environmentalmicrobiome.biomedcentral.com/articles/10....

New groups of highly divergent proteins in families as old as cellular life with important biological functions in the ocean - Environmental Microbiome

Background Metagenomics has considerably broadened our knowledge of microbial diversity, unravelling fascinating adaptations and characterising multiple novel major taxonomic groups, e.g. CPR bacteria...

environmentalmicrobiome.biomedcentral.com