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Johne’s disease (JD), caused by Mycobacterium avium subspecies paratuberculosis (MAP), is a chronic infectious enteritis that threatens both domestic and wild ruminants, including the wood bison-a species of conservation concern in North America. onixonpoint.substack.com/p/diagnostic...
Diagnostic Strategies and Strain Typing for Johne's Disease in Wood Bison (Bison bison athabascae)
Optimizing Detection and Understanding MAP Strain Diversity in a Threatened Wildlife Species
onixonpoint.substack.com
From malnutrition-related diabetes to genetic forms like MODY5 and the debated link between Alzheimer’s and insulin resistance, the diabetes landscape is broader and more complex than ever. onixonpoint.substack.com/p/type-5-dia...
Type 5 Diabetes: The Newly Recognized Disease, MODY5, and the Expanding Diabetes Spectrum-Including “Type 3 Diabetes” (Alzheimer’s)
From malnutrition-related diabetes to genetic forms like MODY5 and the debated link between Alzheimer’s and insulin resistance, the diabetes landscape is broader and more complex than ever.
onixonpoint.substack.com
This study aimed to investigate the biopathological characteristics of two distinct E. maxima isolates collected from geographically separated backyard poultry populations in Iran. onixonpoint.substack.com/p/intraspeci...
Intraspecific Variations in Biology and Pathogenesis of Two Eimeria maxima Isolates from Distinct Geographic Locations
Comparative Analysis Reveals Biological and Pathogenic Diversity Among E. maxima Strains in Iranian Poultry
onixonpoint.substack.com
Inhibitory Effects of Manihot esculenta and Aloe barbadensis Leaf Extracts Against Poultry Eimeria Oocyst Sporulation: Alternatives to Antiprotozoal Resistance onixonpoint.substack.com/p/inhibitory...
Inhibitory Effects of Manihot esculenta and Aloe barbadensis Leaf Extracts Against Poultry Eimeria Oocyst Sporulation: Alternatives to Antiprotozoal Resistance
Dose-Dependent, Plant-Based Inhibition of Eimeria Sporulation as a Sustainable Anticoccidial Strategy
onixonpoint.substack.com
Grip strength is associated with a range of health outcomes, from type 2 diabetes to depression. www.bbc.com/future/artic...
Grip strength: The test for your chances of living to 100
Grip strength is associated with a range of health outcomes, from type 2 diabetes to depression. Here’s how to check yours.
bbc.com
OniX OnPoint Animal Health Newsletter: Advances in Poultry Coccidiosis Control: Genetics, Vaccines, and Natural Alternatives Highlights from Recent Research on Immunization, Herbal Strategies, and Genetic Resistance in Poultry Health onixonpoint.substack.com/p/advances-i...
OniX OnPoint Animal Health Newsletter: Advances in Poultry Coccidiosis Control: Genetics, Vaccines, and Natural Alternatives
Highlights from Recent Research on Immunization, Herbal Strategies, and Genetic Resistance in Poultry Health
onixonpoint.substack.com
www.linkedin.com/posts/martin...
OniX OnPoint Newsletter | Martin Duenas | Substack | Martin A. Dueñas
This coming week (M-Thur) in OniX OnPoint: https://lnkd.in/eiPsRtGu OniX OnPoint, your strategic intelligence resource for navigating the startup and biotech innovation ecosystem. 𝐇𝐮𝐦𝐚𝐧 𝐇𝐞𝐚𝐥𝐭𝐡 OniX O...
linkedin.com
Human Monoclonal Antibodies: A Potential Countermeasure Against Clade 2.3.4.4b H5N1 Influenza Characterization of Broadly Neutralizing mAbs and Protection in a Murine Challenge Model onixonpoint.substack.com/p/human-mono...
Human Monoclonal Antibodies: A Potential Countermeasure Against Clade 2.3.4.4b H5N1 Influenza
Characterization of Broadly Neutralizing mAbs and Protection in a Murine Challenge Model
onixonpoint.substack.com
Experimental H5N1 Infection in Dairy Cows: Clinical Outcomes and Viral Dynamics Replication of HPAI H5N1 Clade 2.3.4.4b Genotype B3.13 in Holstein Dairy Cattle Mimics Field Observations onixonpoint.substack.com/p/experiment...
Experimental H5N1 Infection in Dairy Cows: Clinical Outcomes and Viral Dynamics
Replication of HPAI H5N1 Clade 2.3.4.4b Genotype B3.13 in Holstein Dairy Cattle Mimics Field Observations
onixonpoint.substack.com
Pre-existing Human T-Cell Immunity: A Key Defense Against H5N1 Influenza Conservation of Influenza T-Cell Epitopes Between Seasonal Strains and H5N1 Suggests Cross-Reactivity onixonpoint.substack.com/p/pre-existi...
Pre-existing Human T-Cell Immunity: A Key Defense Against H5N1 Influenza
Conservation of Influenza T-Cell Epitopes Between Seasonal Strains and H5N1 Suggests Cross-Reactivity
onixonpoint.substack.com
Comparative Immunogenicity and Protection of H5N1 Vaccines in Geese Evaluation of Five Commercial Vaccines Against Highly Pathogenic Avian Influenza Virus H5N1 Clade 2.3.4.4b in Fattening Geese onixonpoint.substack.com/p/comparativ...
Comparative Immunogenicity and Protection of H5N1 Vaccines in Geese
Evaluation of Five Commercial Vaccines Against Highly Pathogenic Avian Influenza Virus H5N1 Clade 2.3.4.4b in Fattening Geese
onixonpoint.substack.com
Human Monoclonal Antibodies: A Powerful Strategy Against H5N1 Influenza Rapid Generation and Therapeutic Efficacy of mAbs from Convalescent Patients in a Murine Model onixonpoint.substack.com/p/human-mono...
Human Monoclonal Antibodies: A Powerful Strategy Against H5N1 Influenza
Rapid Generation and Therapeutic Efficacy of mAbs from Convalescent Patients in a Murine Model
onixonpoint.substack.com
Recombinant H5N6 Avian Influenza: Enhanced Pathogenicity and Transmissibility Through H9N2 Internal Genes H5N6 viruses with H9N2-derived internal genes exhibit increased pathogenicity and aerosol transmissibility, posing a greater threat to human health. onixonpoint.substack.com/p/recombinan...
Recombinant H5N6 Avian Influenza: Enhanced Pathogenicity and Transmissibility Through H9N2 Internal Genes
H5N6 viruses with H9N2-derived internal genes exhibit increased pathogenicity and aerosol transmissibility, posing a greater threat to human health.
onixonpoint.substack.com
Bispecific PD-1/VEGF Inhibitors: The Next Leap in Cancer Immunotherapy Clinical Momentum and Scientific Validation for Dual Checkpoint and Angiogenesis Blockade onixonpoint.substack.com/p/bispecific...
Bispecific PD-1/VEGF Inhibitors: The Next Leap in Cancer Immunotherapy
Clinical Momentum and Scientific Validation for Dual Checkpoint and Angiogenesis Blockade
onixonpoint.substack.com
OniX OnPoint Animal Health Newsletter: Navigating Avian Influenza: Vaccine Responses, Viral Evolution, and Transmission Risks in Poultry and Dairy Cattle Latest Research on Avian Influenza Vaccines, Immunity, and Transmission in Poultry and Livestock onixonpoint.substack.com/p/onix-onpoi...
OniX OnPoint Animal Health Newsletter: Navigating Avian Influenza: Vaccine Responses, Viral Evolution, and Transmission Risks in Poultry and Dairy Cattle
Latest Research on Avian Influenza Vaccines, Immunity, and Transmission in Poultry and Livestock
onixonpoint.substack.com
Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study onixonpoint.substack.com/p/multiple-s...
Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study
Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study
onixonpoint.substack.com
Targeted Restriction of Isoleucine and Valine, but Not Leucine, Promotes Metabolic Health and Offers New Strategies for Obesity and Diabetes Prevention onixonpoint.substack.com/p/distinct-r...
Distinct Roles of Isoleucine and Valine in Mediating the Adverse Metabolic Effects of Branched-Chain Amino Acids
Targeted Restriction of Isoleucine and Valine, but Not Leucine, Promotes Metabolic Health and Offers New Strategies for Obesity and Diabetes Prevention
onixonpoint.substack.com
Antibody-Drug Conjugates (ADCs): Precision Powerhouses Transforming Cancer Therapy From concept to clinic—how ADCs are evolving to become smarter, safer, and more versatile weapons against cancer and beyond. onixonpoint.substack.com/p/antibody-d...
Antibody-Drug Conjugates (ADCs): Precision Powerhouses Transforming Cancer Therapy
From concept to clinic—how ADCs are evolving to become smarter, safer, and more versatile weapons against cancer and beyond.
onixonpoint.substack.com
Evolutionary Lineage-Specific Genomic Imprinting at the ZNF791 Locus Discovery of Novel Imprinted Genes in Domesticated Animals onixonpoint.substack.com/p/evolutiona...
Evolutionary Lineage-Specific Genomic Imprinting at the ZNF791 Locus
Discovery of Novel Imprinted Genes in Domesticated Animals
onixonpoint.substack.com
YL201: A Promising Antibody-Drug Conjugate for Advanced Solid Tumors Phase 1 Trial Demonstrates Encouraging Efficacy and Acceptable Safety Profile of a B7H3-Targeting ADC in Refractory Cancers onixonpoint.substack.com/p/yl201-a-pr...
YL201: A Promising Antibody-Drug Conjugate for Advanced Solid Tumors
Phase 1 Trial Demonstrates Encouraging Efficacy and Acceptable Safety Profile of a B7H3-Targeting ADC in Refractory Cancers
onixonpoint.substack.com
YL201: A Promising Antibody-Drug Conjugate for Advanced Solid Tumors Phase 1 Trial Demonstrates Encouraging Efficacy and Acceptable Safety Profile of a B7H3-Targeting ADC in Refractory Cancers onixonpoint.substack.com/p/yl201-a-pr...
YL201: A Promising Antibody-Drug Conjugate for Advanced Solid Tumors
Phase 1 Trial Demonstrates Encouraging Efficacy and Acceptable Safety Profile of a B7H3-Targeting ADC in Refractory Cancers
onixonpoint.substack.com
Getah Virus Identified in Wild Boar in China: A Novel Epidemiological Threat First Report and Genetic Characterization Reveals High Prevalence and GIII Subtype Identification in Wild Boar Population onixonpoint.substack.com/p/getah-viru...
Getah Virus Identified in Wild Boar in China: A Novel Epidemiological Threat
First Report and Genetic Characterization Reveals High Prevalence and GIII Subtype Identification in Wild Boar Population
onixonpoint.substack.com
PDCdb: the biological activity and pharmaceutical information of peptide-drug conjugate (PDC) PDCdb: the biological activity and pharmaceutical information of peptide-drug conjugate (PDC) onixonpoint.substack.com/p/pdcdb-the-...
PDCdb: the biological activity and pharmaceutical information of peptide-drug conjugate (PDC)
PDCdb: the biological activity and pharmaceutical information of peptide-drug conjugate (PDC)
onixonpoint.substack.com
Serum Albumin Drives Cross-Sensitization in Furry Animal Allergies A Component-Resolved Diagnostics Study Reveals the Molecular Basis for Cross-Reactivity Beyond Lipocalins onixonpoint.substack.com/p/serum-albu...
Serum Albumin Drives Cross-Sensitization in Furry Animal Allergies
A Component-Resolved Diagnostics Study Reveals the Molecular Basis for Cross-Reactivity Beyond Lipocalins
onixonpoint.substack.com
Enhancing the Bystander Effect of Antibody-Drug Conjugates by Using a Novel Caspase-3 Cleavable Peptide Linker to Overcome Tumor Heterogeneity onixonpoint.substack.com/p/enhancing-...
Enhancing the Bystander Effect of Antibody-Drug Conjugates by Using a Novel Caspase-3 Cleavable Peptide Linker to Overcome Tumor Heterogeneity
A DEVD Linker Enables Dual Intracellular and Extracellular Payload Release, Sustaining Bystander Killing in Heterogeneous Tumors Even After Antigen-Positive Cell Depletion.
onixonpoint.substack.com
OniX OnPoint Animal Health Newsletter: Unveiling Insights in Infection, Immunity and Genetics Tackling Animal Health Challenges Through Breed Specificity, Allergic Responses, and Cross Species Dynamics onixonpoint.substack.com/p/onix-onpoi...
OniX OnPoint Animal Health Newsletter: Unveiling Insights in Infection, Immunity and Genetics
Tackling Animal Health Challenges Through Breed Specificity, Allergic Responses, and Cross Species Dynamics
onixonpoint.substack.com
This week's issue of OniX OnPoint highlights significant developments in antibody-drug conjugate (ADC) technology across academic research, tech transfer opportunities, and commercial advancement. onixonpoint.substack.com/p/onix-onpoi...
OniX OnPoint Issue #38: ADC Innovation Spotlight
Breaking Advances in Antibody-Drug Conjugate Technologies & Strategic Partnerships
onixonpoint.substack.com