What if enzymes thought to self-destruct… didn’t? 🧐 🧬 Our comparative genomics study suggests some Thi4 thiazole synthases may avoid self-inactivation by tapping into sulfur relay systems and metal cofactors.

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

Comparative genomic insights into the action of suicide Thi4 thiazole synthases https://www.biorxiv.org/content/10.1101/2025.09.23.678117v1

Excited to share the Hanson Lab’s @adhansonlab.bsky.social new preprint! We used OrthoRep to evolve Arabidopsis HDH, a short-lived enzyme, selecting variants with up to 20× higher abundance. Mutations boosted lifespan, catalytic efficiency, or inhibitor resistance. 🔗 www.biorxiv.org/content/10.1...