Director, John Curtin School of Medical Research - Canberra / ACT, ACT, Australia

Classification: Academic Level E Terms: Full time, Fixed term up to 5 years The Australian National University (ANU) is seeking to appoint an outstanding Director, John Curtin School of Medical Resear...

jobs.anu.edu.au

Eduardo Eyras appointed Director of Shine‑Dalgarno Centre for RNA Innovation | EMBL Australia

From being recruited through a highly competitive international search to Centre Director, Professor Eduardo Eyras has charted an impressive journey at EMBL Australia. After joining the John Curtin Sc...

emblaustralia.org

biorxiv.org

The Shine-Dalgarno Centre for RNA Innovation

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jcsmr.anu.edu.au

In remembrance of Peer Bork  | EMBL

EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.

embl.org

Resolving systematic bias in nanopore-based RNA modification detection

Nanopore direct RNA sequencing has accelerated the growth of the epitranscriptomics field, yet nanopore-based RNA modification landscapes are generally unreliable due to the heuristic and unvalidated ...

biorxiv.org

SWARM: A Single-Molecule Workflow for High-Precision Profiling of RNA Modifications

Nanopore direct RNA sequencing promises to decode the epitranscriptome by detecting multiple modifications on individual RNA molecules, but its potential for biological discovery is hampered by high f...

biorxiv.org

Quantification of transcript isoforms at the single-cell level using SCALPEL - Nature Communications

Single-cell RNA-seq facilitates the study of transcriptome diversity in individual cells. Here, authors introduce a tool for isoform quantification at the single-cell level using 3’ scRNA-seq data, co...

nature.com

CSIRO Industry PhD Program Information Session - CSIROBlog icon

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Rachel Thomas, PhD - Deep learning gets the glory, deep fact checking gets ignored

an AI researcher going back to school for immunology

rachel.fast.ai

Postdoctoral Research Fellow, Bioinformatics - Cairns, QLD, Australia

James Cook University (JCU) is creating a brighter future for life in the Tropics and beyond, through education and research that makes a difference locally and globally.  We now have an opportunity a...

careers.jcu.edu.au

Prediction of molecular interactions with RNA using AI - CSIRO Industry PhD Program opportunities

This Project will develop deep-learning models to predict interactions of ribonucleic acid (RNA) with other molecules. The expected outcomes are to improve prediction capabilities to decode RNA intera...

research.csiro.au

GitHub - comprna/SWARM: Single-molecule Workflow for Analysing RNA Modifications

Single-molecule Workflow for Analysing RNA Modifications - comprna/SWARM

github.com

Design of an orally bioavailable small molecule that modulates the microtubule-associated protein tau’s pre-mRNA splicing

Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) is caused by the aberrant alternative pre-mRNA splicing of microtubule-associated protein tau ( MAPT ) exon 10, the inclusio...

biorxiv.org

The Druggable Transcriptome Project: From Chemical Probes to Precision Medicines

RNA presents abundant opportunities as a drug target, offering significant potential for small molecule medicine development. The transcriptome, comprising both coding and noncoding RNAs, is a rich area for therapeutic innovation, yet challenges persist in targeting RNA with small molecules. RNA structure can be predicted with or without experimental data, but discrepancies with the actual biological structure can impede progress. Prioritizing RNA targets supported by genetic or evolutionary evidence enhances success. Further, small molecules must demonstrate binding to RNA in cells, not solely in vitro, to validate both the target and compound. Effective small molecule binders modulate functional sites that influence RNA biology, as binding to nonfunctional sites requires recruiting effector mechanisms, for example degradation, to achieve therapeutic outcomes. Addressing these challenges is critical to unlocking RNA’s vast potential for small molecule medicines, and a strategic framework is proposed to navigate this promising field, with a focus on targeting human RNAs.

pubs.acs.org

How bullying becomes a career tool - Nature Human Behaviour

Nature Human Behaviour - How bullying becomes a career tool

nature.com

CSIRO Industry PhD Program (iPhD) scholarship

The CSIRO Industry PhD Program (iPhD) is a four-year research training program, focusing on applied research that benefits industry by solving real-world challenges. It aims to produce the next genera...

science.anu.edu.au

Prediction of molecular interactions with RNA using AI - CSIRO Industry PhD Program opportunities

This Project will develop deep-learning models to predict interactions of ribonucleic acid (RNA) with other molecules. The expected outcomes are to improve prediction capabilities to decode RNA intera...

research.csiro.au

Single-molecule multimodal timing of in vivo mRNA synthesis

mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...

biorxiv.org