eLife
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The funder-researcher collaboration and open-access publisher for research in the life and biomedical sciences. Follow @eLifeCommunity.bsky.social
Looking for a home for your genetics or genomics paper? We review research from across the field including the genetic basis of health and disease, epigenetics, genomics, population genetics and more. Take a look at what we publish ⬇️ buff.ly/BU53f0L
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling elifesciences.org/articles/104...
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling
The IFT172 C-terminus bridges IFT-A and IFT-B complexes through mutually exclusive interactions with IFT140 and IFT144, and harbors a U-box-like domain linking intraflagellar transport to ubiquitin-dependent...
elifesciences.org
Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies
Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies
Human midbrain organoids provide a foundation for the development of patient-specific preclinical models to support personalized therapeutic approaches and enable evaluation of disease mechanisms and...
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Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies
Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies
Human midbrain organoids provide a foundation for the development of patient-specific preclinical models to support personalized therapeutic approaches and enable evaluation of disease mechanisms and...
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As part of eLife's drive to innovate and make scientific publishing more sustainable and equitable, we work with institutions to offer publishing agreements where, if eligible, you can publish with us for free. Find out more ⬇️ buff.ly/zjg6C0J
From multiplicity of infection to force of infection in sparsely sampled high-transmission <i>Plasmodium falciparum</i> populations
From multiplicity of infection to force of infection in sparsely sampled high-transmission Plasmodium falciparum populations
Queuing theory links multiplicity of infection (MOI) to force of infection (FOI), enabling the estimation of transmission intensity for falciparum malaria (and other infectious diseases) from sparsely...
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From multiplicity of infection to force of infection in sparsely sampled high-transmission <i>Plasmodium falciparum</i> populations
From multiplicity of infection to force of infection in sparsely sampled high-transmission Plasmodium falciparum populations
Queuing theory links multiplicity of infection (MOI) to force of infection (FOI), enabling the estimation of transmission intensity for falciparum malaria (and other infectious diseases) from sparsely...
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A postdoc comes with challenges and uncertainties different from those of a PhD. In this ecrLife blog Vartika Sharma shares how managing expectations and building a community are key skills that can help us navigate the new uncertainties of a postdoc.
The Invisible Skills of a Postdoc: What No One Formally Teaches
A postdoc comes with challenges and uncertainties that are different from those of a PhD. Here, Vartika Sharma shares how managing expectations and building a community are key skills that can help…
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Dopamine and its receptor <i>DcDop2</i> are involved in the coevolution between ‘<i>Candidatus</i> Liberibacter asiaticus’ and <i>Diaphorina citri</i>
Dopamine and its receptor DcDop2 are involved in the coevolution between ‘Candidatus Liberibacter asiaticus’ and Diaphorina citri
CLas hijacks the DA/DcDop2-miR-31a-AKH-JH signaling cascade to improve D. citri lipid metabolism and fecundity, while simultaneously promoting its replication.
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Neural signatures of model-based and model-free reinforcement learning across prefrontal cortex and striatum
Neural signatures of model-based and model-free reinforcement learning across prefrontal cortex and striatum
Single-neuron recordings reveal that anterior cingulate cortex and caudate nucleus encode the interaction between rewards, state transitions, and choices that underlies flexible, goal-directed decision-making.
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Paraventricular thalamus hyperactivity mediates stress-induced sensitization of unlearned fear but not stress-enhanced fear learning (SEFL)
Paraventricular thalamus hyperactivity mediates stress-induced sensitization of unlearned fear but not stress-enhanced fear learning (SEFL)
Chemogenetic and in vivo recording approaches reveal how persistent hyperactivity in the posterior paraventricular thalamus promotes sensitization of fear responses to unlearned threats after stress exposure.
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Exploration of precision coregulator TR-FRET identifies diverse signatures for LXR ligands relevant to discovery of nonlipogenic ABCA1 inducers
Exploration of precision coregulator TR-FRET identifies diverse signatures for LXR ligands relevant to discovery of nonlipogenic ABCA1 inducers
Coregulator TR-FRET profiling reveals ligand-specific LXR signaling signatures that can guide the therapeutic design of ABCA1-inducing LXR agonists with attenuated risk of hepatic lipogenesis.
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Metabolic support of trained immune responses in myeloid cells
Metabolic support of trained immune responses in myeloid cells
A review of literature regarding trained immunity (TI) differentiates two distinct stages of metabolic immune regulation, with primary metabolic changes influencing early epigenetic adaptations that drive...
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Tunable Bessel beam two-photon fluorescence microscopy for high-speed volumetric imaging of brain dynamics
Tunable Bessel beam two-photon fluorescence microscopy for high-speed volumetric imaging of brain dynamics
Tunable Bessel beam two-photon fluorescence microscopy enables high-speed volumetric intravital imaging of subcellular dynamics within living mouse brains with fully tunable spatial resolution and volume...
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Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence
Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence
Esr1 directs adolescent transcriptional maturation of medial preoptic GABAergic neurons, enabling the normal development of mating behavior in male and female mice.
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Multi-timescale neural adaptation underlying long-term musculoskeletal reorganization
Multi-timescale neural adaptation underlying long-term musculoskeletal reorganization
Long-term motor recovery after musculoskeletal alteration relies on gradually developing novel compensatory movements to overcome the rigid, maladaptive timing of stable muscle synergies.
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Material damage to multielectrode arrays after electrolytic lesioning is insignificant
Material damage to multielectrode arrays after electrolytic lesioning is insignificant
An analysis of the largest publicly available collection of scanning electron microscopy images of explanted multielectrode arrays reveals that electrolytic lesioning causes no significant additional...
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Retraction: Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants
Retraction: Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants
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Enterovirus D68 2A protease causes nuclear pore complex dysfunction and independently contributes to motor neuron toxicity
Enterovirus D68 2A protease causes nuclear pore complex dysfunction and independently contributes to motor neuron toxicity
Enterovirus D68, a cause of acute flaccid myelitis, disrupts the composition and function of the nuclear pore complex primarily through its 2A protease, which is also toxic to motor neurons.
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Enterovirus D68 2A protease causes nuclear pore complex dysfunction and independently contributes to motor neuron toxicity
Enterovirus D68 2A protease causes nuclear pore complex dysfunction and independently contributes to motor neuron toxicity
Enterovirus D68, a cause of acute flaccid myelitis, disrupts the composition and function of the nuclear pore complex primarily through its 2A protease, which is also toxic to motor neurons.
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This Reviewed Preprint provides important insights into the field of genomic and transcriptomic prediction of traits across multiple environments. The rationale and analyses conducted to integrate the two types of ~omics datasets across two environments are solid.
Uncovering genetic mechanisms underlying trait variation in switchgrass using explainable artificial intelligence
Altmetric provides a collated score for online attention across various platforms and media.See more details
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Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity
Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity
Disrupting oligodendrocytes during a narrow early-life window leaves cerebellar circuits permanently mistimed, but adult re-synchronization restores social and motor behavior.
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Single-step in vitro reconstitution of the <i>Escherichia coli</i> ribosome mediated by two GTPase factors, EngA and ObgE
Single-step in vitro reconstitution of the Escherichia coli ribosome mediated by two GTPase factors, EngA and ObgE
A multi-step ribosome assembly method involving changes in ion concentration and temperature can now be carried out in a single step using the two GTPase factors, EngA and ObgE.
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Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype
Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype
A genetic analysis in yeast establishes that multicellularity can arise as a side-effect (passenger phenotype) of a completely independent fitness advantage unrelated to the benefits of group formation...
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Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype
Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype
A genetic analysis in yeast establishes that multicellularity can arise as a side-effect (passenger phenotype) of a completely independent fitness advantage unrelated to the benefits of group formation...
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Quantifying intracellular mechanosensitive response upon spatially defined mechano-chemical triggering
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