🥳 Very happy to see this collaborative work now published in @emboreports.org ! From T cells to Dictyostelium, it reveals a conserved pathway controlling amoeboid migration speed. Many thanks to @pdehio.bsky.social , Christoph and colleagues for involving our lab! doi.org/10.1038/s443...

A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration - EMBO Reports

Amoeboid cell migration is key to efficient T cell immunity. Spatial polarization of organelles within cells, including endo-lysosomes, is a prerequisite of migration. However, how ultrastructural polarization is linked to the signaling requirements governing T cell migration remains unknown. Here we show that signaling molecules generated by endo-lysosome-localized kinases regulate velocity of amoeboid migration. Specifically, imaging of T cells identifies accumulation of endo-lysosomes decorated with the lipid kinases VPS34–PIKfyve at the uropod of polarized cells. Activity of VPS34 and PIKfyve regulates speed, but not directedness, of migrating T cells. Mechanistically, PI(3,5)P2 generated by the sequential action of VPS34 and PIKfyve, mediates Ca2+ efflux from lysosomes via the mucolipin TRP cation channel 1 (TRPML1), thus controlling activity of myosin IIA and hence the generation of propulsive force through retrograde actin flow. The VPS34–PIKfyve kinases also regulate velocity of myeloid cells, as well as of the amoeba Dictyostelium discoideum – establishing the axis as an evolutionarily conserved speed control system of amoeboid cell migration.

doi.org

Weekend reading: this back and forth about a p16 reporter mouse for senescence and aging research. Read here in @emboreports.org and many more comments PubPeer. It seems to me that many journals are quite reluctant to publish these correspondences, to their great detriment.

What if you could hear scientific data instead of see it? 🧪 A Science & Society article in EMBO Reports explores how #sonification, the use of sound to represent data, could interpret complex datasets and make #science more accessible: https://link.springer.com/article/10.1038/s44319-024-00230-6

Aflah Hanafiah, Zhonghua Gao et al show that cPRC1.2 complex forms #chromatin loops at poised bivalent promoters. A switch from cPRC1.2-mediated to CTCF-mediated active loops enables differentiation to #neuronal progenitors and activation of lineage-specific genes. link.springer.com/article/10.1...

“… the most impactful publications in modern science are increasingly not primary theoretical or experimental findings, but the methodological innovations that enable and support them.” Read the full Science & Society article by Krauss, Rosenfeld & Bornmann -> link.springer.com/article/10.1...

The second July issue is online: link.springer.com/journal/4431... The cover features work by Naoyuki Inagaki, Kio Yagami and colleagues from NAIST describing spontaneous membrane protrusion and cell morphogenesis via self-propelled #actin filaments. -> link.springer.com/article/10.1...

A new review is online! Monja Müller, Konstanze Winklhofer @ruhr-uni-bochum.de and Fulvio Reggiori discuss the role of E3 #ubiquitin ligases in selective types of #autophagy. -> link.springer.com/article/10.1...

A new review is online! Umut Sahin and Elif Nur Firat-Karalar @cytolabkoc.bsky.social describe the role and alterations of the #centrosome - #cilium - satellite axis in neurodegenerative disease and discuss potential mechanism-based therapeutic strategies. -> link.springer.com/article/10.1...

This knowledge, published in @emboreports.org, has potential in the design and improvement of #immunotherapy treatments. 5/ link.springer.com/article/10.1...

Poorly perfused tumor regions harbor T cells with a glucose-dependent effector phenotype - EMBO Reports

Effector T lymphocytes are avid nutrient consumers, but can function in nutrient-poor tumor microenvironments. Availability of key nutrients such as glucose inside the tumor is not homogeneous, and ho...

link.springer.com

A beautiful image (and study), indeed! A similar image was featured on the Cover of our June issue, Volume 27, issue 12! => link.springer.com/journal/4431...

Biomedical Picture of the Day BPoD@bpodaily.bsky.social · 3w ago

Stn1 protein regulated by the Wnt signalling pathway plays a key role in zebrafish early egg development Image made using @leicamicrosystems.bsky.social microscopy 📷 Xin Zhang, Yanpeng Zhai & Caixia Wang et al Ocean University of China in @emboreports.org ➡️ bpod.org.uk/archive/2026...

A Science & Society article reflects on 100 years of the theory of the gene – from its role in explaining inheritance to how it laid the foundation for modern #genetics and continues to evolve with discoveries: https://link.springer.com/article/10.1038/s44319-026-00770-z 🧪 #LifeSciences #research

Francesca Pappacena, Jean-Michel Cioni and co-workers show that lc3b mRNA is translated on #endosomes in #axons and that this local synthesis is vital for clearance of dysfunctional endosomes by #autophagy. #ProteinSynthesis #neurons -> link.springer.com/article/10.1...

Yanis Macé, Nicolas Bidère and co-workers show that CYLD is a target of #caspase -3. CASP3-induced cleavage of CYLD tempers inflammatory signaling and heps maintain #apoptosis silence. #inflammation #CellDeath #ubiquitin -> link.springer.com/article/10.1...

The first July issue is online: link.springer.com/journal/4431... The cover features work by Hsiao-Ying Kuo from NYCU Taipei describing activity-dependent #development of #vocal circuits in the neonatal rodent #forebrain. -> link.springer.com/article/10.1...

Philippe Dehio @pdehio.bsky.social, Christoph Hess and co-authors describe a conserved VPS34-PIKfyve pathway regulating #T cell and amoeboid cell migration speed via #lysosome Ca2+ efflux, #myosin IIA activation and retrograde #actin flow. -> link.springer.com/article/10.1...

Mindong Ren, Michael Schlame and co-authors show that cardiolipin de novo synthesis, but not remodeling, is essential for mouse postnatal maturation of cardiac mitochondria, respiratory chain biogenesis and cardiac function. #lipid #mitochondria -> link.springer.com/article/10.1...

Gayatri Rai, Bama Charan Mondal and co-authors show that the COP9 signalosome and Cullin-RING #ubiquitin ligases regulate the cell fate of myeloid-type blood progenitors in Drosophila via EGF and #WNT #singaling. -> link.springer.com/article/10.1...

Academic independence after the USA's 250th anniversary of the Declaration of Independence? Read why the proposed #OMB policies would undermine research & economic leadership + comment by July13th shorturl.at/2s6f8). At the same time we must get our house in order. link.springer.com/article/10.1...

Academic independence? - EMBO Reports

EMBO Reports - US federal policies to establish a ‘gold standard science’ threaten to undermine academic freedom. Individual scientists and institutions must re-articulate why the...

link.springer.com

Timo-Daniel Voss @unihohenheim.bsky.social and co-authors show that C-terminal lysine residues localise NLRP10 at lipid droplets and govern #NLRP10 oligomer formation. link.springer.com/article/10.1... Press releases: www.uni-hohenheim.de/index.php?id... idw-online.de/de/news873496

Schistosomiasis affects 110 million African children. Its control demands an urgent shift from drug treatments to permanent transmission interruption. Read the article by Francisca Mutapi and Mark EJ Woolhouse here: -> link.springer.com/article/10.1...

Margot Sahnine, Dorian Obino and co-workers @pasteur.fr show that N. meningitidis induces membrane protrusions with distinct #F-actin networks in epithelial and endothelial cells. The branched network in endothelia depends on Arf1. #Host-pathogen #membrane -> link.springer.com/article/10.1...

Naoyuki Inagaki at Nara Institute of Science and Technology (NAIST) and co-workers show spontaneous #membrane protrusion and cell morphogenesis happens via self-propelled #actin filaments. link.springer.com/article/10.1... Read the press release here: www.naist.jp/en/research_...

See our second June issue! link.springer.com/journal/4431... The cover features work by Xin Zhang, Xiaozhi Rong, Jianfeng Zhou and co-workers showing that CST complex subunit Stn1 amplifies #Wnt/beta-catenin signaling and ensures proper #oocyte development. -> link.springer.com/article/10.1...

A new review is online! Wassim Daher, Laurent Kremer and co-authors @umontpellier.bsky.social @inserm.fr @irim-life.bsky.social tell you all you need to know about organelle interplay in host responses and #mycobacterial #resilience. -> link.springer.com/article/10.1...

Elena Sindram, Laura Gámez-Díaz and colleagues @uni-freiburg.de show that LRBA interacts with non-muscle myosin IIA and regulates the #actin #cytoskeleton and #immune synapse formation in #BCells #Lymphocyte #antigen -> link.springer.com/article/10.1...

LRBA regulates actin cytoskeleton dynamics through NMIIA during B cell immune responses - EMBO Reports

Patients with lipopolysaccharide-responsive beige-like anchor protein (LRBA) deficiency typically suffer from severe B cell dysfunction. However, the underlying mechanisms remain incompletely understo...

link.springer.com

Philipp Rieche, Marten Exterkate, Arnold Driessen et al show that the #lipid divide between #bacteria and #archaea is not as strict as previously thought as bacterial lipid synthesizing enzymes can use both stereo-forms of glycerol-phosphate. #MembraneBiology -> link.springer.com/article/10.1...

Bacterial lipid synthesizing enzymes PlsY and PlsC utilize both stereo-forms of glycerol-phosphate - EMBO Reports

The chemical composition of membrane lipids differs between eukarya, bacteria and archaea. The central dogma posits that the stereochemistry of phospholipids in bacteria is distinct from archaea. Bact...

link.springer.com

Emmanuel Amzallag, Eran Hornstein and colleagues show that the E3 #ubiquitin ligase MKRN2 maintains granulostasis by preventing the accumulation of misfolding-prone DRiPs into #StressGranules. -> link.springer.com/article/10.1...

The E3 ligase MKRN2 prevents DRiP accumulation in stress granules and maintains granulostasis - EMBO Reports

Stress granules (SGs) are transient cytoplasmic biomolecular condensates that play a role in the cellular response to proteotoxic stress. It has been previously shown that ubiquitination regulates SG ...

link.springer.com

See our first June issue! link.springer.com/journal/4431... The cover features work by Daniel Ríos @yosoyden.bsky.social at UNAM in Mexico City and co-workers showing that the #ECM scaffolds interdependent #tissue morphogenesis in #Drosophila. link.springer.com/article/10.1...

Congratulations to Mayra Aguirre-Garcia from Annemarie Meijers lab @unileiden.bsky.social for receiving the EMBO reports poster prize at #EMBOpathogenSignalling for her work "GBP1 recruitment to Mycobacteria-containing vesicles through calcium signalling drives #macrophage lysosomal defenses".

A new review on #evolution is online! Pavithra Venkataraman and Christian Landry @christianlandry.bsky.social discuss a conceptual framework for the joint influence of coding and regulatory mutations in shaping fitness and impacting molecular #evolution. -> link.springer.com/article/10.1...

Molecular evolution in light of regulatory-coding epistasis - EMBO Reports

Predicting the fitness effects of mutations is central to understanding molecular evolution and interpreting genome sequence data. Such predictions remain challenging due to the inter-dependent roles ...

link.springer.com