www.biorxiv.org/content/10.6... New preprint from our lab! Solving antagonist-bound GPCR structures is becoming easier with fusion markers, but linker optimization between GPCR and marker is still a bottleneck. (1/2)
Hideaki E. Kato
@emekato.bsky.social
Professor at UTokyo. (postdoc @Stanford) / b.1986 / structural biology, protein engineering, rhodopsin, GPCRs http://tinyurl.com/ycyf87t7
Happy to share our work on conventional and time-resolved cryo-EM studies of NTSR1, now published in Nature! nature.com/articles/s41... Wonderful collab. w/ Sumino, Mitsutake, Kobilka, & Inoue labs. Congrats to Kazuhiro, Kouki, Toshiki, Shun & everyone involved!
The dynamic basis of G-protein recognition and activation by a GPCR - Nature
Conventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates and uncovering key mechanistic step...
nature.com
Happy to share our new preprint on the red-shifted channelrhodopsin ChR024, recently discovered by Inoue Lab (biorxiv.org/content/10.1... ), highlighting its long-wavelength absorption and ion conductance: biorxiv.org/content/10.1... Many thanks to our wonderful lab members and collaborators!
Happy to share our work on the ligand selectivity and allosteric regulation of FFA2 using a combination of cryo‑EM, MD simulations, and mol. pharmacology! It was a great collab. with Ishikita, Dror, and Inoue labs. Congrats to Mai, Kouki, Ryoji, and everyone involved! www.nature.com/articles/s41...