Endocrinology Advisor
@endocrinologyadv.bsky.social
Endocrinology Advisor provides healthcare professionals with comprehensive information and clinical news on the management of endocrine conditions.
The initiation of #tirzepatide therapy significantly decreases the incidence of myocardial infarction and all-cause mortality among high-risk individuals with type 2 #diabetes. https://www.endocrinologyadvisor.com/news/tirzepatide-mace-risk-type-2-diabetes-ascvd/
Tirzepatide Reduces Cardiovascular Events in Type 2 Diabetes
Tirzepatide therapy reduces the risk for major adverse cardiovascular events in patients with type 2 diabetes and established CVD.
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Risk of new-onset #depression and anxiety remains significantly elevated in patients with endogenous #CushingSyndrome, even among those who successfully achieve biochemical remission. https://www.endocrinologyadvisor.com/news/cushing-syndrome-depression-anxiety-risk/
Cushing Syndrome Linked to Nearly Doubled Risk for Depression and Anxiety
Patients with Cushing syndrome have a significantly higher risk for depression and anxiety that persists even after achieving biochemical remission.
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A proposed 2-step machine learning framework that distinguishes phenotype discovery from clinical validation may enable individualized risk prediction and personalized #care pathways for patients with #MASLD. https://www.endocrinologyadvisor.com/news/machine-learning-precision-phenotyping-masld/
Machine Learning Model May Improve Precision Phenotyping in MASLD
A proposed machine learning framework for metabolic dysfunction-associated steatotic liver disease may improve personalized risk prediction.
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Antenatal magnesium sulfate exposure in extremely #preterm infants is associated with increased survival without #CerebralPalsy or moderate to severe functional impairment. https://www.endocrinologyadvisor.com/news/magnesium-sulfate-cerebral-palsy-preterm-birth/
Exposure to Antenatal Magnesium Sulphate Beneficial in Extremely Preterm Births
Real-world data show antenatal magnesium sulfate protects against cerebral palsy and mortality in extremely preterm infants.
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Intensive physician training that incorporates role-playing significantly improved glycemic control and #metabolic outcomes in patients with type 2 #diabetes. https://www.endocrinologyadvisor.com/news/physician-role-playing-type-2-diabetes-control/
Role-Playing-Based Physician Training Improves Glycemic Control in T2D
Researchers tested whether intensive physician training with role-playing can improve glycemic control in patients with type 2 diabetes.
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Women with overweight or #obese body mass index trajectories during childhood have an increased risk for #infertility later in life. https://www.endocrinologyadvisor.com/news/childhood-bmi-trajectory-female-infertility/
Women With Obese BMI Trajectory in Childhood at Higher Risk for Infertility
Researchers found that childhood body mass index trajectories influence the likelihood of childbirth and infertility in adult women.
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Patients with #obesity and primary #aldosteronism are at increased cardiovascular disease risk and have a reduced likelihood of achieving a complete clinical response to surgical or medical therapy. https://www.endocrinologyadvisor.com/news/obesity-primary-aldosteronism-clinical-outcomes/
Obesity Is Associated With Poorer Clinical Outcomes in Primary Aldosteronism
For patients with obesity and primary aldosteronism, there is a link to a higher cardiometabolic burden and poorer clinical response to targeted treatments.
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#Racial and ethnic disparities exist in the use of #diabetes technologies, addressing which will advance the promotion of equitable care in diabetes. https://www.endocrinologyadvisor.com/news/racial-ethnic-disparities-diabetes-technology/
Racial and Ethnic Disparities Persist in Diabetes Technology Use
Black and Hispanic vs non-Hispanic White individuals with diabetes were less likely to use continuous glucose monitoring and insulin pumps.
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#Semaglutide exposure before or during #pregnancy was associated with increased risk for adverse pregnancy outcomes. https://www.endocrinologyadvisor.com/news/semaglutide-exposure-adverse-pregnancy-outcomes/
Semaglutide Exposure in Pregnancy Related to Adverse Outcomes
Semaglutide use before or during pregnancy may increase risk for adverse outcomes like gestational diabetes and excessive weight gain.
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Integrating standardized #physical #fitness tests into routine clinical practice may improve risk stratification and guide targeted interventions for older adults. https://www.endocrinologyadvisor.com/news/standardized-fitness-tests-may-refine-risk-for-mortality-in-older-adults/
Standardized Fitness Tests May Refine Risk for Mortality in Older Adults
Better performance on standardized physical fitness tests is associated with a lower risk for all-cause mortality in older adults.
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#Metformin does not enhance the functional improvements achieved through diet and exercise in older adults with #obesity and functional impairment. https://www.endocrinologyadvisor.com/news/lifestyle-intervention-metformin-obesity-function/
Metformin Adds No Functional Benefit to Lifestyle Changes in Obesity
Intensive lifestyle intervention improves physical function in older adults with obesity, but adding metformin provides no extra benefit.
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Among individuals with #migraine with aura, the risk for #stroke was low and similar among users of combined oral contraceptives and progestogen-only pills, although the findings were imprecise. https://www.endocrinologyadvisor.com/news/combined-oral-contraceptives-stroke-risk-migraine/
Do Combined Oral Contraceptives Increase Stroke Risk in Migraine With Aura?
Stroke risk is similar among individuals with migraine with aura who use combined oral contraceptives or progestogen-only pills.
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Hormonal suppression therapies for #endometriosis were associated with a reduction in #BoneMineralDensity, highlighting the need for standardized bone health surveillance. https://www.endocrinologyadvisor.com/news/endometriosis-treatment-bone-loss-risk/
Hormonal Therapies for Endometriosis Linked to Reduced Bone Density
Hormonal treatments for endometriosis may lead to reduced bone mineral density in reproductive-aged women and people assigned female at birth.
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The Endocrine Society has issued a statement to note updated clinical practice guidelines regarding #testosterone replacement therapy in men with #hypogonadism. https://www.endocrinologyadvisor.com/news/endocrine-society-statement-testosterone-replacement-therapy-hypogonadism/
Endocrine Society Issues Statement on Testosterone Replacement Therapy for Men With Hypogonadism
In a statement, the Endocrine Society announced updated guidelines for testosterone replacement therapy in men with hypogonadism.
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Strategies widely employed over the last 30 years to treat type 1 #diabetes (#T1D) in adolescent patients were associated with a reduced risk for microvascular complications. https://www.endocrinologyadvisor.com/news/type-1-diabetes-microvascular-complications-adolescents/
Examining Trends in T1D Complications Among Adolescents Over 30 Years
A recent study explores the long-term trends in microvascular complications and the impact of insulin therapy in pediatric type 1 diabetes.
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High visceral adipose tissue is independently associated with #testosterone levels, suggesting that low testosterone may be a phenotype of #VisceralAdiposity. https://www.endocrinologyadvisor.com/news/visceral-adiposity-low-testosterone-men/
Visceral Fat Is Inversely Correlated With Testosterone Levels
Visceral adiposity may be a better predictor of low testosterone in men than body mass index or waist circumference, according to new data.
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In #pediatric patients with diabetic ketoacidosis, smaller initial fluid boluses and alternatives to prolonged 0.9% saline rehydration may reduce the risk for adverse events, such as #hypoglycemia. https://www.endocrinologyadvisor.com/news/pediatric-diabetic-ketoacidosis-fluid-regimens/
Evaluating Fluid Resuscitation Safety in Pediatric Patients With Diabetic Ketoacidosis
A systematic review evaluates the safety and efficacy of various fluid resuscitation regimens for pediatric patients with diabetic ketoacidosis.
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Low free and total #testosterone concentrations independently predict an increased risk of frailty among older men living with #HIV. https://www.endocrinologyadvisor.com/news/low-testosterone-frailty-risk-men-hiv/
Low Testosterone Predicts Increased Frailty Risk in Older Men With HIV
Low concentrations of free and total testosterone independently predict an increased risk for incident frailty among older men with HIV.
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People living with #HIV who take an #antiretroviral therapy regimen containing protease inhibitors or who have a longer duration of infection are at an increased risk for low serum cortisol levels. https://www.endocrinologyadvisor.com/news/art-regimens-cortisol-levels-hiv/
ART Regimen Influences Cortisol Levels in People Living With HIV
Researchers evaluated the impact of specific antiretroviral therapy regimens on morning serum cortisol levels among people living with HIV.
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For couples experiencing #infertility, adherence to traditional healthy vs specific fertility #dietary patterns may improve the chances of achieving a live birth. https://www.endocrinologyadvisor.com/news/traditional-vs-fertility-diets-infertility-couples/
Traditional Healthy vs “Fertility” Diets: Which Is More Effective in Improving Fertility Outcomes?
Researchers evaluated the impact of traditional healthy dietary patterns vs fertility-focused diets on live birth rates among patients experiencing infertility.
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Access to continuous glucose monitoring and insulin pumps may not be sufficient to eliminate disparities in #glycemic outcomes associated with social determinants of health among some patients with #diabetes. https://www.endocrinologyadvisor.com/news/diabetes-technology-socioeconomic-disparities/
Social Determinants Affect Glycemic Control Despite CGM and Insulin Pump Use
Continuous glucose monitoring and insulin pumps may not eliminate the effect of social determinants of health on glycemic control in diabetes.
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Use of hormonal #contraceptives may be associated with an increased risk for #meningioma, which dissipates after discontinuation of therapy, suggesting that doctors should monitor these patients for tumor growth. https://www.endocrinologyadvisor.com/news/hormone-contraceptives-meningioma-risk/
Hormone Contraceptive Therapies May Contribute to Meningioma Risk in Women
The use of certain hormone contraceptive therapies may increase the risk of developing meningioma in women.
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In patients with biochemically controlled endogenous #CushingSyndrome, normalization of late-night salivary #cortisol levels was associated with improved psychological well-being and quality of life. https://www.endocrinologyadvisor.com/news/cortisol-rhythm-restoration-cushing-syndrome-recovery/
Restoration of Cortisol Rhythm Improves Recovery After Cushing Syndrome Treatment
Restoration of the cortisol circadian rhythm in patients with treated Cushing syndrome was linked to improved psychologic well-being and QOL.
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Higher doses of #levothyroxine are associated with an increased risk for suboptimal #hypothyroidism treatment, highlighting the need for more frequent thyroid-stimulating hormone surveillance. https://www.endocrinologyadvisor.com/news/levothyroxine-dose-suboptimal-hypothyroidism-treatment/
Suboptimal Hypothyroidism Treatment Risk Increases With Levothyroxine Dose
Patients receiving high-dose levothyroxine for hypothyroidism may require more frequent thyroid monitoring to prevent suboptimal outcomes.
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Women who conceive using #infertility treatments have a significantly higher risk for unplanned peripartum #hysterectomy compared with those who have unassisted conceptions. https://www.endocrinologyadvisor.com/news/infertility-treatment-peripartum-hysterectomy-risk/
Infertility Treatments Linked to Increased Risk for Peripartum Hysterectomy
Women who conceive using infertility treatments may face higher risk for unplanned peripartum hysterectomy compared with unassisted conceptions.
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Among adults with #prediabetes, lifestyle intervention, but not #metformin, was associated with a lower burden of multimorbidity during 21 years of follow-up. https://www.endocrinologyadvisor.com/news/t2d-multimorbidity-lifestyle-interventions-metformin/
Lifestyle Interventions More Effective Than Metformin for Long-Term Multimorbidity Control in Prediabetes
Compared with metformin or placebo, lifestyle changes were more effective at preventing multimorbidity in patients with diabetes.
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Earlier initiation of antidiabetic #medication following the diagnostic threshold for #T2D resulted in lower risk for all-cause mortality. https://www.endocrinologyadvisor.com/news/early-initiation-of-antidiabetic-medication-in-newly-diagnosed-t2d-reduces-all-cause-mortality/
Early Initiation of Antidiabetic Medication in Newly Diagnosed T2D Reduces All-Cause Mortality
Earlier initiation of antidiabetic medication reduces all-cause mortality in patients with newly-diagnosed type 2 diabetes.
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Many women experiencing the #menopause transition may have a transient resurgence of ovarian activity after anti-Mullerian #hormone levels initially fall below the limit of detection. https://www.endocrinologyadvisor.com/news/ovarian-activity-rebound-menopause-transition/
Ovarian Activity Can Rebound During Menopause Transition
A recent study explores how anti-Mullerian hormone levels can rebound after falling below detection limits during menopause.
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Consistent resistance training during midlife, especially when combined with #aerobic exercise and limited sedentary behavior, is associated with a substantially lower risk for type 2 #diabetes. https://www.endocrinologyadvisor.com/news/resistance-training-type-2-diabetes-risk/
Resistance Training Linked to Lower Type 2 Diabetes Risk
Consistent resistance training during midlife combined with aerobic activity may lower the risk for type 2 diabetes in adults.
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In adults with obesity and #T2D, sleeve gastrectomy is associated with a higher likelihood of achieving weight loss and glycemic targets at 1 year compared with #semaglutide or #tirzepatide. https://www.endocrinologyadvisor.com/news/sleeve-gastrectomy-semaglutide-tirzepatide-type-2-diabetes/
Sleeve Gastrectomy Outperforms GLP-1s for Weight Loss in Type 2 Diabetes
Sleeve gastrectomy may offer greater weight loss and glycemic control than semaglutide or tirzepatide in adults with obesity and T2D.
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