EPIGENETIC HULK
@epigenetichulk.bsky.social
EPIGENETIC HULK SMASH PUNY GENOME. MAKE GENOME GO. LOCATION: NOT CENTROMERE, THAT FOR SURE
OH SO PROMOTERS LIKE ENHANCERS! WE KNOW FOR DECADES! OH SO IT'S TFS IN PROMOTER! LET SCHAFFER AND STARK KNOW!
Anders Sejr Hansen@andersshansen.bsky.social · last mo.Very interesting new preprint from @jengreitz.bsky.social lab arguing that rather than there being significant enhancer-promoter compatibility, promoters simply differ in their enhancer responsiveness. If promoters are responsive, they respond to all enhancers. www.biorxiv.org/content/10.6...
NANOG! IMPORTANT FOR EMBRYO! NOW IN HUMAN! OOOH WHAT NEWS! PAGING AUSTIN AND SHINYA SO THEY NOW LEARN SOMETHING THEY DISCOVERED! www.nature.com/articles/s41...
Base editing reveals an essential role for NANOG in human embryogenesis - Nature
Nature - Base editing reveals an essential role for NANOG in human embryogenesis
nature.com
NUCLEOSOME NOMENCLATURE JUST FINE! WHY BE SO CRAZY! {[("H3meLIKEY2"])} www.cell.com/molecular-ce...
A needed nomenclature for nucleosomes
Keogh et al. propose a nomenclature to clearly and concisely describe the post-translational modifications, proteoforms, and nucleoforms that drive chromatin function. This communicates experimental n...
cell.com
🎵WHY DO ENHANCER! SUDDENLY APPEAR! EVERY TIME! THEY ARE NEAR!?! JUST LIKE ME! THEY LONG TO BE! CLOSE TO POLII! 🎵 www.nature.com/articles/s41...
Distal enhancers loop to proximal enhancers, not to promoters - Nature Reviews Molecular Cell Biology
This Comment posits that enhancers stimulate the transcription machinery only through short-range interactions and, therefore, that enhancer activity at a distance is mediated by chromatin loops betwe...
nature.com
1992 CALLED THEY WANT THEIR MECHANISM BACK! CHROMATIN REMODELER REMODEL CHROMATIN! SOMETIME THIS GOOD FOR TXN! SOMETIME BLOCK IT! GOOD JOB WITH THE NUCLEOSOMES!
Surfin' NuRD@surfinnurd.bsky.social · 11mo agoCheck it out, Chromatin Kids! Chromatin remodeller does stuff to Transcription Factors! Functions where it is seldom seen! Both decreases and increases chromatin accessibility! How cool is that?
IT BEST HEALTH! FOR SKIN! MAYBE ELAINE FUCHS INVOLVED! NEED CELLULAR EPIGENETICS FOR EVERYTHING PLEASE!
Carmelo Ferrai@carmeloferrai.bsky.social · 11mo ago@magnanilab.bsky.social What a hell is that? 🤪
CRAMP! SO ANNOYING BUT NEEDS TO KEEP LINKER HISTONES! EPIGENETIC HULK DO WITHOUT! UNLESS IT THE BAND SO THEN COOL! www.cell.com/molecular-ce...
CRAMP1 drives linker histone expression to enable Polycomb repression
Challenging the prevailing view that H1 linker histones represent a general feature of repressed chromatin, Matthews et al. show a specific requirement for H1 in epigenetic repression by PRC2. Ablatio...
cell.com
www.cell.com/cell/abstrac... PERTURB EVERYTHING! LOOK AT IT IT! OK GOOD PLAN IF WANT TO KNOW WHAT ONE LITTLE CELL CARES! ALL THESE EVERYTHING STUFF DON'T SMASH REAL BIOLOGY! ONLY PERIPHERAL EASY TO HIT STUFF!
cell.com
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!