New from Epigenome Technologies: Paired-Tag - the first single-cell multiomic assay that simultaneously captures RNA expression and epigenetic marks #Epigenetics #SingleCell #PairedTag #Multiomics Find out more at: u.epigenome.us/pCTHvQHK

Epigenetics Update - X-chromosome inactivation draws L1 mutagenesis to the human X chromosome u.epigenome.us/GELEGziG John V. Moran (umich.edu) and faulknerlab.bsky.social (University of Queensland) in science.org #Epigenetics #XCI #Mutagenesis --- Cancer, immunology, and aging; epigenometech.com

Epigenetics Update - Spatiotemporal multiomics uncover tumor ecosystem dynamics during metastatic colonization u.epigenome.us/pT4mqLmP #Epigenetics #Multiomics #Cancer #Metastasis --- Empower your research with high-res epigenetic insights at epigenometech.com

Epigenetics Review - Genomic, epigenomic and transcriptomic regulation of cellular senescence u.epigenome.us/lBcKOMoZ Laura J. Niedernhofer and Linshan Laux (univofminnesota.bsky.social) in natrevgenet.nature.com #Epigenetics #Reviews #Senescence --- Discover the breakthrough at epigenometech.com

Genomic, epigenomic and transcriptomic regulation of cellular senescence - Nature Reviews Genetics

Senescence — a complex, dynamic and heterogeneous stress-responsive cell state — shapes ageing biology and tissue homeostasis. This Review examines the molecular regulation of senescence initiation, m...

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Epigenome Technologies offers an end-to-end Single-Cell CUT&Tag service Our expert scientists run the entire workflow on your samples - from preparation to data analysis #Epigenetics #SingleCell #CUTandTag Find out more at: u.epigenome.us/Xz86EjGJ

Epigenetics Update - Mitochondrial metabolism and epigenetic crosstalk drive SASP u.epigenome.us/0A04jhX7 Peter D. Adams (sbpdiscovery.bsky.social) and João F. Passos (mayoclinic.org) in nature.com #Epigenetics #Mitochondria #Metabolism #Inflammation --- Gain deeper insights at epigenometech.com

Epigenetics Update - Intestinal stem cells count self-renewal divisions to switch multipotency u.epigenome.us/aBazn9es Dong Tong/Anqi Li and Zheng Guo in nature.com #Epigenetics #StemCells #Multipotency #Chromatin --- High-resolution insights without cell sorting; epigenometech.com

Intestinal stem cells count self-renewal divisions to switch multipotency - Nature

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...

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Epigenetics Update - Phage hijacks host phosphorothioate DNA modification machinery to circumvent bacterial Ssp defences u.epigenome.us/fWJBurF5 Shi Chen and Lianrong Wang in Nature Microbiology #Epigenetics #DNAm #Phages --- Perfect for cancer, immunology, and aging research; epigenometech.com

Phage hijacks host phosphorothioate DNA modification machinery to circumvent bacterial Ssp defences - Nature Microbiology

The phage-encoded protein PptA enables its DNA to masquerade as the host and evade cleavage, providing a potential foundation for engineering therapeutic phages that could bypass this widespread defen...

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New from Epigenome Technologies: the first fully validated Single-Cell CUT&Tag kit Fully compatible with 10x Chromium® (ATAC), Fluent PiP-seq®, or BD Rhapsody #Epigenetics #SingleCell #CUTandTag Find out more at: u.epigenome.us/NYjSGQao

Epigenetics Review - Epigenetic regulation of kidney development u.epigenome.us/isCCpJVw Samir S. El-Dahr (tulanemedicine.bsky.social) and Jordan Kreidberg (harvardmed.bsky.social) in natrevneph.nature.com #Epigenetics #Reviews #Kidney --- Empower your research at epigenometech.com

Epigenetic regulation of kidney development - Nature Reviews Nephrology

This Review describes current understanding of the epigenetic regulation of kidney development. It describes the epigenetic drivers of cell fate decisions made by nephron progenitor cells, the chromat...

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Epigenetics Preprint - Single-cell analysis of chromatin accessibility and gene expression in Drosophila melanogaster embryos following hypoxia treatment u.epigenome.us/tHOzyklv Bing Ren & Gabriel G. Haddad in BioRxiv #Epigenetics #Preprint #SingleCell #Chromatin #Drosophila --- epigenometech.com

Epigenetics Update - Nuclear class 3 PI3K co-activates fasting-specific chromatin remodelling u.epigenome.us/XAZ7hea5 Nathaniel F. Henneman & Ganna Panasyuk (Université de Paris Cité) in natcellbio.nature.com #Epigenetics #Chromatin #PI3K --- Gain deeper insights into regulation; epigenometech.com

Epigenetics Review - BRD4: From molecular understanding to therapeutics development u.epigenome.us/wYBPetIA Shwu-Yuan Wu and Cheng-Ming Chiang (UT Southwestern Medical Center) in Molecular Cell #Epigenetics #Review #BRD4 --- High-resolution insights without cell sorting; epigenometech.com

BRD4: From molecular understanding to therapeutics development

Bromodomain-containing protein 4 (BRD4) is an important therapeutic target for anticancer, antiviral, and anti-inflammatory responses. In this review, Wu and Chiang discuss how BRD4, as a universal ep...

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Epigenetics Update - Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease u.epigenome.us/h6JXevwj Hansruedi Mathys, Zhijun Duan, and jianma.bsky.social in science.org #Epigenetics #Alzheimers --- Cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation u.epigenome.us/EK1q7b5V David G. Schatz & sstevenwang.bsky.social (yaleschoolofmed.bsky.social) in science.org #Epigenetics #Tonsils --- Empower your research: epigenometech.com

Epigenetics Update - Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants u.epigenome.us/JM4Hph2T Liudan Jiang/Long Zhao and Chuan He in natgenet.nature.com #Epigenetics #IDRs #HistoneDemethylase #Plants --- epigenometech.com

Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants - Nature Genetics

Intrinsically disordered regions impose regulatory restraints on gene-activating demethylases, limiting chromatin engagement and preserving genomic stability. This function is a key determinant of the...

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Epigenetics Update - Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development u.epigenome.us/XHlUqkVP Tao Zhang / assumeassume.bsky.social & Nian Liu in Cell #Epigenetics #Condensates #Chromatin #ANKRD11 --- Gain deeper insights at epigenometech.com

Epigenetics Update - Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program u.epigenome.us/Z8Z1qdJ9 Spiros Palikyras and akispapantonis.bsky.social in nataging.nature.com #Epigenetics #Senescence #Splicing #Aging --- Gain hi-res insights at epigenometech.com

Epigenetics Update - Subnuclear genome compartmentalization controls bivalent chromatin activity u.epigenome.us/kmYQv4vy Daniel A. Lim (ucsanfrancisco.bsky.social) in Nature #Epigenetics #Chromatin #Bivalency --- Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina u.epigenome.us/QMSgfBBj Radha Ayyagari and Bing Ren (ucsandiego.bsky.social) in Science Advances #Epigenetics #SingleCell #Retina #Chromatin --- Empower your research at epigenometech.com

Epigenetics Perspective - The impact of microbial metabolites on host chromatin and epigenetic regulation u.epigenome.us/lBvMhQS6 Tohfa Kabir, Zoe K. Lawler, and Leah A. Gates in natmetabolism.nature.com #Epigenetics #Perspective #Microbes #Metabolites #Chromatin --- epigenometech.com

The impact of microbial metabolites on host chromatin and epigenetic regulation - Nature Metabolism

This Perspective describes the emerging roles of microbiota-derived metabolites in influencing host chromatin and thereby gene regulation and host physiology.

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Epigenetics Update - Human body single-cell atlas of three-dimensional genome organization and DNA methylation u.epigenome.us/lCLovkSu jesserdixon.bsky.social and Joseph R. Ecker (salkinstitute.bsky.social) in science.org #Epigenetics #DNAm --- Gain deeper insights; epigenometech.com

Epigenetics Update - Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor u.epigenome.us/GnuUsdpy Katherine S. Pollard and benoitbruneau.bsky.social (gladstoneinst.bsky.social) in science.org #Epigenetics #Chromatin --- epigenometech.com

Epigenetics Update - SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry u.epigenome.us/mKCIy53t Brian J. Liddicoat, jessebalic.bsky.social, and thedawsonlab.bsky.social in natgenet.nature.com #Epigenetics #DNAm #ViralMimicry #SUMOylation --- epigenometech.com

SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry - Nature Genetics

This study uses a highly selective inhibitor to elucidate DNMT1’s specific functions and their regulation. Notably, RFN4-mediated SUMOylation enhances DNMT1 mobility and DNA methylation, thereby promo...

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Epigenetics Update - Epigenetic and 3D genome reprogramming during the aging of the human hippocampus u.epigenome.us/SMQq9RYe Xiangmin Xu (ucirvinemedschool.bsky.social) and Bing Ren (ucsdmedschool.bsky.social) in science #Epigenetics #Aging --- Empower your research at epigenometech.com

Paired-Tag in the Wild! - Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure u.epigenome.us/QEV8cqHE @allenywphd.bsky.social, Stavros Drakos, Kyle Gaulton, Bing Ren, & Neil C. Chi in Science #Epigenetics #PairedTag #EpigenomeTech --- epigenometech.com

Epigenetics Update - A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death u.epigenome.us/ChQGizP6 Michael R. Green, Stephen M. Hinshaw, Nathanael S. Gray, and Gerald R. Crabtree in Cell #Epigenetics #Cancer #Acetyltransferases --- epigenometech.com

Epigenetics Perspective - Positioning TERT at the apex of aging u.epigenome.us/n0GerkF0 Ronald A. DePinho (@mdanderson.bsky.social) in @nataging.nature.com #Epigenetics #Perspective #TERT #Telomerase --- High-resolution insights without cell sorting; epigenometech.com

Positioning TERT at the apex of aging - Nature Aging

This Perspective reviews TERT’s canonical telomere-maintenance and noncanonical regulatory roles in aging and outlines an evidence-based framework for evaluating TERT- and telomere-directed geroprotec...

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Epigenetics Update - Promoter strength and position govern promoter competition through transcript-dependent insulation u.epigenome.us/j416bd7s Mervenaz Koska and Joanna Wysocka (Stanford University) in Nature Genetics #Epigenetics #Promoters #Enhancers --- epigenometech.com

Promoter strength and position govern promoter competition through transcript-dependent insulation - Nature Genetics

By inserting diverse promoters at the mouse Sox2 locus, Koska et al. show that promoter strength, position and transcript length tune promoter competition through transcription-dependent insulation, i...

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Learn about single-cell epigenetic profiling by downloading our guide to single-cell CUT&Tag and single-cell Paired-Tag, which provides comparisons to other methods and bioinformatic insight #Epigenetics #Multiomics #CUTandTag #10XGgenomics #ChIPSeq #SingleCell #PairedTag u.epigenome.us/mHSAqLpl