What does the ribosome need to initiate translation? - an AUG codon. Yes but not only ! - a Kozak context. In fact, it is much more complicated than that and different in every species ! Check out our latest publication: doi.org/10.1016/j.ce... @cnrs-alsace.bsky.social @cnrs.fr @unistra.fr
link.springer.com/article/10.1...
N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer's disease - Translational Neurodegeneration
Background Tauopathies are a group of neurodegenerative diseases, including Alzheimer’s disease (AD), characterized by progressive accumulation of pathological Tau proteins. Among the diverse Tau spec...
link.springer.com
Dans cette terrible maladie, les motoneurones, cellules à l’origine des mouvements volontaires, se dégradent, entraînant une paralysie progressive. Ce sont des protéines qui sont en jeu. Et on sait maintenant précisément comment elles sont produites ! 👉 https://l.sciencesetavenir.fr/9O7
Kudos to @eriani-martinlab.bsky.social and team for this important discovery !
CNRS@cnrs.fr · 7mo ago#PressRelease🗞️ A specific molecular mechanism has been identified as the cause of the most frequent genetic forms of amyotrophic lateral sclerosis (ALS, also known as Charcot’s disease) and frontotemporal dementia (FTD). 👉 www.cnrs.fr/en/press/discov...
#PressRelease🗞️ A specific molecular mechanism has been identified as the cause of the most frequent genetic forms of amyotrophic lateral sclerosis (ALS, also known as Charcot’s disease) and frontotemporal dementia (FTD). 👉 www.cnrs.fr/en/press/discov...
Maladie de Charcot : le mécanisme à l’origine de la forme génétique de la pathologie a été découvert theconversation.com/maladie-de-c...
Maladie de Charcot : le mécanisme à l’origine de la forme génétique de la pathologie a été découvert
La découverte du mécanisme biologique à l’origine des formes génétiques de maladie de Charcot offre une cible thérapeutique prometteuse.
theconversation.com
I'm thrilled to anounce that our latest study on ALS/FTD neurodegenerative diseases has been published. Very proud to be part of this excting project. Many thanks to Clotilde Lagier Tourenne for an amazing longlasting and fruitfull collaboration, #ALS #FTD #Ribosomes www.science.org/doi/10.1126/...
Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes
GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxicity is thought to result from the accumulation...
science.org
Congratulations to Yann Tardivat for his PhD defense last Friday October 10th on the translation mechanisms during SARS-CoV-2 infection. A collaborative project with @novalix_pharma ! #sars @ARN67IBMC @unistra
Last Wednesday October 8th, Antoine Perret defended his PhD entitled: Investigation of Tau mRNA translation mechanisms in Alzheimer’s Disease patients. Congratulations for this great achievement. A great collaborative project with @LucBuee and Malika Hamdane from Lille University
www.linkedin.com/posts/activi...
#emblprotein #emblprotein #research #translation #molecularbiology #collaboration #als #ftd #c9orf72 #neurodegenerativediseases | Paulo da Costa
I had the privilege to give the talk "Targeting dipeptide repeat protein synthesis rescues C9ORF72-linked ALS/FTD phenotypes" at the Protein Synthesis and Translational Control Conference (#EMBLProtei...
linkedin.com
Congratulations to Augustin Burn who tremendously succeeded in the grant competition for a PhD fellowship, welcome to the lab Augustin, we are looking forward to working with you!!!!
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planet-vie.ens.fr/thematiques/...
La traduction : de l’ARN messager à la protéine
La traduction correspond à l'étape de décodage de l'information génétique contenue dans l'ARN messager pour produire une protéine. Cette étape essentielle dans l'expression du génome nécessite l'inter...
planet-vie.ens.fr
Mapt mutations are found in brain disorders. Most of them are located in sequences encoding microtubule-binding domains. However, some are in the 5'UTR tau mRNAs. Understanding the effect of mutations in the amino-terminal part of tau and the role of N-truncated tau academic.oup.com/narmolmed/ar...
FTLD-MAPT mutations and short 5′UTR Tau mRNAs increase Tau translation
Abstract. Tau protein plays a central role in Alzheimer’s disease (AD) and other tauopathies. Tau proteins aggregate in degenerating neurons and their expr
academic.oup.com
🔥🔥🔥 Notre app #HelloQuitteX est sortie ! Récupérez vos followers de X en moins de 5 min, il suffit de récupérer votre archive X. Le #20Janvier, on vous reconnecte avec tous vos abonnés de X ! Yes we can ! Rejoignez ➡️ app.helloquitx.com Dessin de @cartooningforpeace.bsky.social
Our latest study on Tau translation is online #MAPT #Tau #Alzheimer @ErianiLab @LucBuee academic.oup.com/narmolmed/ad...
FTLD-mapt mutations and short 5′UTR tau mRNAs increase tau translation
Abstract. Tau protein plays a central role in Alzheimer's disease (AD) and other Tauopathies. Tau proteins aggregate in degenerating neurons and its expres
academic.oup.com