Severe Covid leads to persistent viral reactivation, with >10 different viruses noted in the first 40 days after hospital admission. Long Covid was specifically associated with reactivation of latent Anelloviridae virus @nature.com www.nature.com/articles/s41...

Virus reactivation in acute and long COVID-19 - Nature

Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune signatures with prog...

nature.com

Accurately predicting an individual's health arc is a dream that has not been previously possible. Now we're headed there, thanks to a new @nature.com paper by Sarah Urbut and team. Our conversation and annotations in the new Ground Truths erictopol.substack.com/p/predicting...

Predicting Your Health Arc

Sarah Urbut MD, PhD Takes Us Through Her Landmark Nature Paper

erictopol.substack.com

Less protein, more lifespan! A comprehensive review of the merits of protein restriction for healthy aging A flip from the proteinmaxxing craze cell.com/cell-press-b...

Inflammation is a driver of age-related diseases (inflammaging) and this new NYT magazine article gets deep into the progress that is being made to track and block it gift link www.nytimes.com/interactive/...

Inflammation Keeps Us Alive. It's Also Making Us Sick. (Gift Article)

The discovery that chronic inflammation is a cause of myriad illnesses could be this century's biggest medical breakthrough.

nytimes.com

Killer T cells (CD8+) in Long Covid directed to SARS-CoV-2 and Herpes virus antigens are persistent and may have a causal role www.cell.com/cell-reports...

Persistent cytolytic CD8+ T cells recognize SARS-CoV-2 and herpesvirus epitopes in long COVID

Ma et al. perform deep-phenotyping of CD8+ T cells specific for viruses implicated in LC pathogenesis: SARS-CoV-2, CMV, and EBV. These T cells from LC individuals share features of terminal differenti...

cell.com

you didn't need AI to predict this..... www.nytimes.com/2026/07/24/w...

Measles Cases Hit New Record in U.S., as Vaccination Rates Wane (Gift Article)

The Trump administration has sent mixed messages on vaccinations against measles as cases have continued to climb.

nytimes.com

The pro-peptide stacked FDA advisory committee voted to lift the ban for BPC-157, as expected. This ban lifting is baseless and will give the public a sense of legitimacy for a peptide with no clinical trial data to support safety or efficacy. Pathetic.

Around the world, life expectancy is increasing but the gap vs healthspan is widening. That is, more sickspan. The US has the largest morbidity gap. Let that sink in: The US has the largest morbidity gap. www.thelancet.com/journals/lan...

"Perhaps the worst blow to food safety science was the administration’s elimination of the National Advisory Committee on Microbiological Criteria for Foods, a group of experts whose recommendations have informed many major food safety programs." gift link www.nytimes.com/2026/07/20/o...

Immune response in 18/20, so that’s a large subset. And while it’s true that the trial wasn’t designed to show prevention per se, all 20 had genetic predisposition to PDAC and all of them already had radiographic lesions. So it’s quite encouraging nonetheless.

This is big. The first vaccine tested to PREVENT pancreatic cancer in high-risk individuals aacrjournals.org/cancerdiscov...

The aortic dissection that led to Senator Graham's sudden death. Could it have been prevented? What is being done to reduce the toll of aortic dissection with so many people having a dilated proximal aorta and so few progressing to a catastrophic event? www.statnews.com/2026/07/15/l...

Graham’s death from aortic dissection raises questions about preventing the rare disorder

When the body’s most important blood vessel tears from the inside, it’s a medical emergency that can be years in the making.

statnews.com

The serious looming further threat to US science www.newyorker.com/magazine/202...

An O.M.B. Plan to Defund Science—and Anything Trump Doesn’t Like

Under a new proposal, Administration officials could deny government grants to any group or project on the ground that it didn’t fit the President’s agenda.

newyorker.com

To get better protection against respiratory infections and transmission we need to achieve nasal immunity. A new @cp-immunity.bsky.social review www.cell.com/immunity/abs...

Nasal immunity in respiratory viral infection, transmission, and protection

The nasal mucosa is a key decision point during respiratory viral infection. Here, Kazer et al. review new understanding of how local host cell subsets respond during viral infection and how this know...

cell.com

It's medicine's clock moment. We don't age linearly or synchronously (our organs and cells). That leads to an inflection point for promoting health and preventing diseases. erictopol.substack.com/p/medicine-i...

Medicine is Moving From Calendars to Clocks

Proteins Tell How Fast Our Organs and Cells Are Ticking

erictopol.substack.com

GLP-1 drugs helped people with diabetes to prevent pulmonary fibrosis, #LongCovid Work in patients and the mouse model. Open-access journals.asm.org/doi/full/10....

Long Covid persistent eye symptoms can be debilitating and appear to be related to chronic T-cell mediated neuroinflammation. open-access www.nature.com/articles/s41...

RFK Jr refusing to meet with US Preventive Task Force for the 4th time www.nytimes.com/2026/07/06/u...

Key Health Care Panel Is Again Blocked From Meeting

nytimes.com

For treatment and outcomes for cancer, the tumor microenvironment is pivotal, but we've never had a non-invasive way to assess it. Until now, a blood test breakthrough! With sequencing >10 million cells + AI, discovery & validation of a blood test that informs response to therapy and prognosis.

On our 250th birthday, celebrating the contribution of immigrants and international collaboration —46% of people with doctoral-level degrees working in US science and engineering fields are foreign-born

On the future of health, towards primary prevention gift link www.wsj.com/health/welln...

The Future of Health—From Head to Toe

Early detection for all sorts of ailments will allow doctors to treat conditions before a lot of damage is done.

wsj.com

Trust in science in the United States @nature.com by @helenpearson.bsky.social www.nature.com/articles/d41...

A comprehensive assessment of the safety of mRNA vaccines thelancet.com/journals/lan...

Prevention and early detection of breast cancer. A very informative conversation with Dr. Elisa Port For example, Mt Sinai provides AI mammography for all patents getting screened, without charge We covered a lot of ground open.substack.com/pub/erictopo...

Elisa Port: Discuss THE BREAST ADVICE Book

A recording from Eric Topol's live video with annotations below

open.substack.com

When AI helped save 45-year-old man's life. www.nature.com/articles/s41... gift link www.nytimes.com/2026/06/22/h...

Doctors Thought It Was Asthma. A.I. Flagged a Serious Heart Problem.

nytimes.com

Two of the most important biomedical breakthroughs came from science of the Gila lizard venom (GLP-1s) and yogurt (CRISPR genome editing). "The system that turned that lizard into a medicine is now being dismantled." gift link nytimes.com/2026/06/20/o...

Who owns your health data? It should be you. The AI arms race is making matters worse. feature @naturemedicine.bsky.social nature.com/articles/s41...

Who owns my health data? - Nature Medicine

The geopolitics driving artificial intelligence superpowers is reshaping biomedical datasets, and who has access to them.

nature.com

In defiance of Koch's postulates that establish a causal relationship between a microbe and a disease.

Beginning July 1st, $50/month for Ozempic or Zepbound for all Medicare Part D enrollees sounds great. But here's the truth and it's not very good at all. by @dusetzinas.bsky.social @nejm.org today nejm.org/doi/full/10....

Epstein -Barr Virus has an established role in the risk of multiple sclerosis. But the opposite—protection—appears to be true for this virus and Type 1 autoimmune diabetes. nature.com/articles/s41...

Epstein–Barr virus might protect against type 1 diabetes mellitus - Nature Reviews Endocrinology

Epstein–Barr virus is suspected to have a role in autoimmune disorders such as multiple sclerosis and systemic lupus erythematosus. In type 1 diabetes mellitus, however, clinical and experimental stud...

nature.com