Huge congratulations to Brian on smashing his DPhil defence - now Dr Leung! 🎓 And massive thanks to the wonderful examiners @thedownslab.bsky.social and @jansenlab.bsky.social for such engaging discussions!

Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social‬

Centromeres as minefields: host–virus warfare

Cell Research - Centromeres as minefields: host–virus warfare

rdcu.be

Nicolas Manel Lab@manellab.bsky.social · last yr.

Thrilled to share our latest @cp-cell.bsky.social. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS. www.cell.com/cell/abstrac...

We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️ www.cell.com/cell-reports...

The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability

Graham et al. demonstrate that BRCA2 and PALB2 protect centromere integrity in non-cancerous cells through distinct mechanisms, partly counteracting the mismatch repair factor MLH1. In cancer cells, B...

cell.com