Thanks to all involved in the super exciting work! Happy reading! And happy to answer any questions!
Eugene Kim Lab
@eugenekimlab.bsky.social
The Eugene Kim Lab, Max Planck Institute of Biophysics, Germany https://www.biophys.mpg.de/structure-dynamics-of-chromosomes
Furthermore, we show a new role for M18BP1 as a condensin II loop stabiliser! Condensin II alone has a short loop lifetime, but when bound by M18BP1, loops are super stable. This is due to a basic region of M18BP1 contributing to DNA binding and loop anchoring!
I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima www.biorxiv.org/content/10.6...
biorxiv.org
How is Condensin II activated during mitosis? 🧬 @damlatetiker.bsky.social Samejima et al. uncover how Condensin II autoinhibition is relieved by the mitotic activator M18BP1, and reveal that M18BP1 also forms a composite DNA anchor with the NCAPG2–NCAPH2 subcomplex to stabilize DNA loops in vitro.
biorxiv.org
Our work on SMC Wadjet is finally out! Congrats to all co-authors!
Biswajit Pradhan@bislightyear.bsky.social · 2y agoHappy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪
