What if the next breakthrough in #extracellularvesicle biology comes from a fly? 🪰 Evolution has conserved the core machinery of EV biology, making #Drosophila a powerful platform for discovering mechanisms relevant to human health. 🔗: sciexplor.com/exo/articles... #exosomes

Why blocking lymphangiogenesis isn't always the right strategy for cancer therapy? 🎙️Listen to this episode of EXO Chats: www.sciexplor.com/exo/podcast/2 📖Read the article: www.sciexplor.com/exo/articles... #CancerImmunotherapy #LymphaticBiology #TumorImmunology #CancerResearch #Immunotherapy

🤝 EXO - Beyond the Cell × Columbia University Libraries: Advancing Open Access EXO warmly welcomes Columbia University Libraries as our Institutional Participant! 🔗 News: www.sciexplor.com/news/exo_131 #ColumbiaUniversityLibraries #OpenAccess #LifeScience #Spatialbiology

We are pleased to present Volume 1 Issue 2 of EXO – Beyond the Cell, featuring 7 open-access articles from leading scientists that provide new insights into cell–environment interactions. Read and explore: www.sciexplor.com/exo/volume/5... #CellBiology #Spatialbiology #cancer #SpatialOmics

Exercise is more than a lifestyle intervention — it is a window into new cancer therapeutic possibilities. Read the full article: www.sciexplor.com/exo/articles... Read the news: www.eurekalert.org/news-release... #ExerciseOncology #CancerResearch #CancerImmunotherapy #metabolomics #gutmicrobiome

What makes BRCA1 and BRCA2 respond differently to ferroptosis? 🎙️Listen to this episode of podcast for answer: www.sciexplor.com/exo/podcast/1 📖 Read the article for more content: www.sciexplor.com/exo/articles... #Ferroptosis #BRCA #ExtracellularVesicles #CancerResearch #CellBiology

💡 How can we better interpret the complex data generated by spatial biology technologies? Insights into STAMP data analysis provide new perspectives. 🔗 Read the Alert: eurekalert.org/news-release... 📖 Read the Article: sciexplor.com/exo/articles... #spatialbiology #singlecelltranscriptomics

💡Understanding how Drosophila genetics can illuminate conserved EV mechanisms in vivo has emerged as an important frontier in extracellular vesicle research. 🔗 Read the news: eurekalert.org/news-release... 📖 Full article: sciexplor.com/exo/articles... #Extracellularvesicles #exosomes

🎉 New Perspective published in EXO! 📖 Beyond the treadmill: Exercise oncology as a platform for translational advance By Dr. Emma S. Kurz & Prof. Dafna Bar‑Sagi 🔗Explore exercise-induced anti-tumor mechanisms: www.sciexplor.com/exo/articles... #ExerciseOncology #CancerImmunotherapy #EXOBeyondTheCell

Why do identical #mitochondrialdysfunction cause different disease outcomes? A Perspective in EXO proposes that clonal lineage mosaicism and cellular history may help explain tissue-specific vulnerability in #mitochondrialdisease. 🔗Read: www.sciexplor.com/exo/articles... #SpatialOmics #Mitochondria

💡Understanding how ferroptosis propagates between cells has emerged as an important frontier in ferroptosis research. 🔗 Read the Alert: www.eurekalert.org/news-release... 📖 Read the Review: www.sciexplor.com/exo/articles... #Ferroptosis #CellDeath #ExtracellularVesicles #EXOBeyondtheCell

🎉 New Perspective published in EXO! 📖 Decoding the Clonal Origins of Mitochondrial Pathology By Prof. Navdeep S. Chandel and Prof. Yogesh Goyal from Northwestern University 🔗Explore lineage-resolved insights into mitochondrial pathology: www.sciexplor.com/exo/articles... #Mitochondria #Metabolism

From mechanism to function: How Drosophila unlocks the secrets of EV biology. This Review maps EV pathways across species & shows how in vivo genetics accelerates functional discovery. Read more: sciexplor.com/exo/articles... #ExtracellularVesicles #Exosomes #Drosophila #Genetics

🎉We are pleased to share the publication of the new Review! 📖Extracellular vesicles in Drosophila and mammals: Conserved mechanisms and emerging functional roles Led by Prof. Norbert Perrimon (Harvard Medical School). Free to read: www.sciexplor.com/exo/articles... #Extracellularvesicles #exosomes

🎙️EXO Chats Ep03 is LIVE! Thousands of secreted factors circulate through our bodies, but many still have no known receptors. Prof. @brentstockwell.bsky.social talks with Prof. Norbert Perrimon & Dr. Myeonghoon Han about decoding #ligand–receptor interactions. 🔗 www.sciexplor.com/exo/podcast/3

Ferroptosis is emerging as a propagative form of cell death, where lipid peroxides, iron, and intercellular signals may drive wave-like death spreading across cell populations. 🔗Read the full review: sciexplor.com/exo/articles... #Ferroptosis #CellDeath #RedoxBiology #LipidPeroxidation

Gene programs are the missing link for interpretable virtual cells. This framework maps perturbations to phenotypes & paves the way for patient digital twins. Read more: www.sciexplor.com/exo/articles... #VirtualCell #GenePrograms #SingleCell #Genomics #SpatialOmics #EXOBeyondtheCell

Decoding the secretome remains a major challenge in understanding intercellular communication. This EXO review highlights emerging approaches—from CRISPR screening to AI-driven prediction—for mapping ligand–receptor networks: sciexplor.com/exo/articles... #Secretome #SystemsBiology #SpatialOmics

A cell’s defense system can also become its vulnerability. The perspective from Loretta Dorstyn & Sharad Kumar the “caspase-2 paradox” — how genome surveillance shapes liver polyploidy, homeostasis, and cancer risk: sciexplor.com/exo/articles... #Polyploidy #GenomeStability #CancerResearch

Spatial omics can map millions of cells. But can we analyze them reliably? The real bottleneck isn't data generation—it's computation. New review from Jasmine Plummer's lab tackles the challenge: sciexplor.com/exo/articles... #SpatialOmics #Bioinformatics #SpatialBiology

🎉New Perspective published in EXO We are pleased to share the publication of: Anchoring virtual cells on gene programs: from biological networks to patient digital twins Led by Dr. Jie Liao, Zhejiang University. 🔗Read: www.sciexplor.com/exo/articles... #VirtualCell #Spatialbiology #SingleCell

#EditorInTheSpotlight Michael Snyder, EXO Editorial Board Member Stanford W. Ascherman Professor of Genetics A pioneer of multi-omics and personalized medicine. Developed iPOP for predictive and longitudinal health monitoring. #MultiOmics #PrecisionMedicine #Genomics #SystemsBiology #Proteomics

We have hundreds of secreted proteins. But for many of them, their receptors remain unannotated: a major bottleneck in decoding intercellular communication. A recent review highlights why ligand–receptor #deorphanization remains difficult: www.sciexplor.com/exo/articles... #Spatialbiology #Secretome

💡 Is ferroptosis a spreading death wave rather than a cell-autonomous process? A growing body of evidence suggests that #ferroptosis is not restricted to individual cells—but can propagate across tissues in wave-like patterns. Read the article: www.sciexplor.com/exo/articles... #CellDeath #lysosome

Science: First Hormone Cell Atlas at single-cell resolution Hormonal signaling is widely distributed across human cells. Secretin detected in immune cells; GLP-1 receptors in heart cells. Led by Prof. Sarah Teichmann & HCA consortium. Read: www.science.org/doi/abs/10.1... #SingleCell #HumanCellAtlas

How do cells talk to each other? Researchers from Harvard Medical School lay out a roadmap to identify orphan signaling receptors using synthetic biology, AI, and spatial omics. 📰 www.eurekalert.org/news-release... 🔗 sciexplor.com/exo/articles... #LigandReceptor #Deorphanization #SpatialOmics

🎉New Mini Review on STAMP technology now published in EXO! Title: Democratizing the spatial view: STAMP technology from an analytical perspective By Drs. Poudel S, Dezem FS, Martelotto LG, Plummer JT, Green DR. 🔗Free to read: sciexplor.com/exo/articles... #SpatialBiology #STAMP #Transcriptomics

📢 New Review Published in EXO! Title: Ferroptosis spreading through propagative signals By Drs. Saloni K. Hombalkar, Jyotirekha Das, and Michael Overholtzer from @mskcancercenter.bsky.social 🔗 Open access: sciexplor.com/exo/articles... #Ferroptosis #CellDeath #RedoxBiology

📢New Review Published in EXO! Title: Computational workflows and data infrastructures for spatial omics analysis By Drs. Jasmine Plummer, Mariah Alexander, Yutian Liu, Felipe Segato Dezem, and Hayden Chasteen 🔗Read: www.sciexplor.com/exo/articles... #SpatialOmics

🎙️EXO Chats Podcast – Ep02 is LIVE! Hosted by @brentstockwell.bsky.social , Dr. Kathryn Jacobs shares her journey in lymphatics study, the discovery blocking autophagy traps T cells & breaks immunotherapy, and her future vision of lymphatic modulation. 🔗Listen: youtube.com/watch?v=yvbo... #Lymphatics

The Lymphatic System: Passive Pipeline or Immune Decider? - EXO Chats Vol.2

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