Frederickson D. Entila, PhD
@fdentila.bsky.social
peeking through immunity dependencies of plant-microbiota dialogues… PS Microbiologist Vera Cruz Lab IRRI Researcher Ismail Lab IRRI PhD Tsuda Lab MPIPZ Post-Doc Hacquard Lab MPIPZ
a pre-print, alternative for mutant library generation for fungi (CRISPRi pools, first-of-its-kind)… www.biorxiv.org/content/10.6...
Pooled CRISPRi screening reveals fungal-specific vulnerabilities across environments and genetic backgrounds
The rising rate of drug-resistant fungal infections and the emergence of fungal pathogens with intrinsic resistance phenotypes are a growing concern. The close evolutionary distance between mammals an...
biorxiv.org
www.nature.com/articles/s41... here they have developed a central vaccine that can elicit immune responses broadly covering many strains by mapping the antigenic and immunogenic space of a viral protein, in principle this can be applied to design plant receptors that can capture wider MAMP epitopes
A vaccine central in A(H5) influenza antigenic space confers broad immunity - Nature
A high-resolution antigenic map of influenza A(H5) haemagglutinin (HA) enables the design of immunogenic and antigenically central vaccine HA antigens that elicit antibody responses broadly covering t...
nature.com
www.science.org/doi/10.1126/... this is a paradigm shift if this happens also to plants, that the surface localized PRRs or parts of it mobilize to the nucleus and directly modulate RNA pol II function, a straight-forward evidence of "transcriptional reprogramming"…
Direct targeting and regulation of RNA polymerase II by cell signaling kinases
Distinct phosphorylation marks are placed on the carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) during different stages of gene transcription. These phospho-CTD marks function as a molec...
science.org
the microbiota of cocoa fermentation is key to the desirable attributes of fine chocolate… www.nature.com/articles/s41...
A defined microbial community reproduces attributes of fine flavour chocolate fermentation - Nature Microbiology
An in-depth microbiological and metagenomic analysis of Colombian farm and fermentation facilities resulted in the design of a defined microbial community that can reproduce the flavour of fine chocol...
nature.com
functional overlap among organ microbiota doesn’t seem to apply for trees as what we usually see in other relatively smaller plants; the internal tissues of trees are so anoxic, nutritionally restrictive, and antimicrobial-rich analogous to mammalian stomach… www.nature.com/articles/s41...
A diverse and distinct microbiome inside living trees - Nature
Microbiome analyses of living trees show that a single tree can host approximately one trillion bacteria, with microbial communities distinctly partitioned between heartwood and sapwood and with minim...
nature.com
even the sight of sick people elicits immune responses as an anticipation for a possible infection… www.nature.com/articles/s41...
Neural anticipation of virtual infection triggers an immune response - Nature Neuroscience
Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived...
nature.com
We present MetaFlowTrain, an easy-to-build, highly parallelized, and cost-effective fluidic system for studying microbial exometabolites and their roles in modulating microbe–microbe–host interactions. Kudos to @chesneau-g.bsky.social @mpipz.bsky.social Give it a try: www.nature.com/articles/s41...
Finally! Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course). www.science.org/doi/10.1126/...
Apoplastic barriers are essential for nodule formation and nitrogen fixation in Lotus japonicus
Establishment of the apoplastic root barrier known as the Casparian strip occurs early in root development. In legumes, this area overlaps with nitrogen-fixing nodule formation, which raises the possi...
science.org
viral coat protein is perceived by RBRL, enhancing its ligase activity to ubiquitinate NINJA3 for degradation leading to de-repression of JA signalling for antiviral defense in rice www.nature.com/articles/s41...
Perception of viral infections and initiation of antiviral defence in rice - Nature
Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.
nature.com
immune-modulation of host plants is requisite for terrestrial predominance of Xanthomonodales strains www.nature.com/articles/s41...
Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota - Nature Plants
The authors show that immunosuppression is highly conserved in the bacterial order Xanthomonadales. This feature, which preceded their specialization as host-adapted pathogens, probably contributes to...
nature.com
the mycorrhizal highways moves in waves with trade interests at the forefront flowing dynamically in both ways within hyphae. www.nature.com/articles/s41...
A travelling-wave strategy for plant–fungal trade - Nature
Symbiotic fungi control network-level structure and flows to meet trade demands.
nature.com
www.science.org/doi/10.1126/... gut microbiota represses lncRNA Snhg9 expression in the intestine to reconfigure lipid metabolism abetting diet-induced obesity in mice.
The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9
The intestinal microbiota promotes lipid absorption and storage by repressing the expression of the long noncoding RNA gene Snhg9.
science.org
cancer cells transfer ROS-resistant defective mitochondria to immune cells rendering it dysfunctional, senescent, and memory deficient to evade immunity… www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
nature.com
expanded bioluminescence spectrum for simultaneous imaging of cellular processes, even with just a smartphone www.science.org/doi/10.1126/...
Creating coveted bioluminescence colors for simultaneous multi-color bioimaging
Twenty-color bioluminescent proteins have been developed for simultaneous imaging of multiple biological targets.
science.org
The siderophore coelichelin from Streptomyces sp. sensitizes the competitor Bacillus subtilis to phage predation via iron-sequestration resulting to inhibition of Spo0A activation. www.nature.com/articles/s41...
Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection - Nature Microbiology
A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.
nature.com
sequence-to-ecology study of Pseudomonas siderophores reveal microbial iron heist: non-pathogenic strains are iron altruists while pathogenic strains are selfish iron hoarders. www.science.org/doi/10.1126/...
Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks
Coevolving siderophore genes shape bacterial iron networks, unveiling the complexity of cheating across habitats and lifestyles.
science.org
New year, new paper! Now published in @nature.com. We identified and characterised diverse immune cell states in plants under pathogen attack. My postdoc work in the Ecker lab at @salkinstitute.bsky.social. A thread (0/n) #PlantScience www.nature.com/articles/s41...
onlinelibrary.wiley.com/doi/abs/10.1... Here we review the mechanistic relevance of innate immunity in orchestrating plant-microbiota dialogues and discuss the pluses and perils of microbiota. Also, we highlighted the role of host immunity in regulating the potentially pathogenic microbiota members.
Taming of the microbial beasts: Plant immunity tethers potentially pathogenic microbiota members
Plants are in intimate association with taxonomically defined microbiota. In here we review recent literature regarding the crucial role of plant immunity in controlling the potentially pathogenic me....
onlinelibrary.wiley.com