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Feldman Lab@WashU

@feldmanlab.bsky.social

We love bacteria!! Especially Acinetobacter and Bacteroides. The lab is in Dept. of Molecular Microbioloy @WashU in St Louis

30 Posts1013 Follower307 Folgt
Feldman Lab@WashU@feldmanlab.bsky.social · 10mo ago

Acinetobacter exhibits cyrcadian rhythms! These bugs can predict the light cycles and adjust the expression of genes accordingy. Amazing collaboration with Alejandra Mussi's team from Rosario, Argentina, my city!! rdcu.be/eIQzL

The critical human pathogen Acinetobacter baumannii exhibits light-regulated circadian rhythms

Communications Biology - Gene expression studies in the critical pathogen Acinetobacter baumannii identified the existence of daily rhythms displaying a robust response to light, as well as...

rdcu.be

Feldman Lab@WashU@feldmanlab.bsky.social · 10mo ago

I said I will never work on phages, but having @micheleleroux.bsky.social next door made me change my mind. Here is Alexis's new paper showing how different phages deal with the capsular barrier to infect Acinetobacter! A great collaboration between our labs! journals.plos.org/plospathogen...

Acinetobacter phages use distinct strategies to breach the capsule barrier

Author summary Acinetobacter baumannii causes life-threatening and often antibiotic-resistant infections thereby posing a global threat. Accordingly, there is an urgent need for alternative treatments...

journals.plos.org

Feldman Lab@WashU@feldmanlab.bsky.social · 10mo ago

Happy to share the last pre-print from my lab. Just in time for Evan’s thesis defense www.biorxiv.org/content/10.1...

Dual Membrane-spanning Anti-Sigma 2 Controls OMV biogenesis and Colonization Fitness in Bacteroides thetaiotaomicron

Bacteroides spp. are Gram-negative, gut commensals that shape the enteric landscape by producing outer membrane vesicles (OMVs) that degrade dietary fibers and traffic immunomodulatory biomolecules. U...

biorxiv.org

Michael Brockhurst@brockhurstlab.bsky.social · last yr.

Highlights how the AMR crisis is also a cancer research issue Redirecting just a tiny fraction of cancer research funding to AMR would be transformative

Antimicrobial resistance #AMR@antimicrobial.bsky.social · last yr.

This large multi-center study shows cancer patients are infected with #AMR bacteria at 1.2 to 3 times higher rates due to frequent hospital visits and antibiotic use. This highlights the need for better antibiotic #stewardship and surveillance in these patients. www.thelancet.com/journals/lan...

Feldman Lab@WashU@feldmanlab.bsky.social · last yr.

Today I gave a talk in Namur with a special guest: Guy Cornelis, the scientist that discovered T3SS and who was my postdoc advisor. He is retired now, came to my talk. I could not resist the temptation to take a selfie when I started my seminar! Academia has these great moments

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Gerry Wright@gdwantibiotics.bsky.social · last yr.

The latest discovery from the lab and great colleagues at McMaster and U Illinois, Chicago. Lariocidin, a new lasso peptide antibiotic that inhibits the ribosome. rdcu.be/efdha

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

Nature - A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common...

rdcu.be

samuel mehr@mehr.nz · last yr.

so far I'm seeing a lot of universities respond to grant terminations with "oh I guess now we don't have that grant anymore" instead of "your assertion of a grant termination is executive overreach, see you in court" So, universities: respectfully, what the fuck?

Maureen Barr@barrlab.bsky.social · last yr.

In a science round table discussion yesterday, my NJ senator @kim.senate.gov suggested a strong argument for NIH and federal funding is global competitiveness. We US-based scientists should start weaving this into our narratives.

Don Moynihan@donmoyn.bsky.social · last yr.

NIH spending more than pays for itself. It generates about $2.5 for every $1 spent. In terms of research productivity, NIH funding dwarfs the rest of the world. The only long-term potential rival is China. Politicizing the NIH's scientific processes will hand China a huge strategic advantage.

graph showing publication of NIH funded publications, relative to other funders. China is catching up.
Mark Copelovitch@mcopelov.bsky.social · last yr.

👇🎯 The public isn't going to understand this, unless the presidents of R1 universities around the country <loudly> & <collectively> get out into the public square & start explaining this & calling out the existential threat to the entire 🇺🇸 university system. The silence is deafening right now.

Tom Pepinsky@tompepinsky.com · last yr.

The public really needs to understand this. Every university system in the world rests on public funding, there has never been an alternative model at any time in history. We have universities for literally the same reason that we have roads and armies.

Gemma Reguera 🌎@microgem.bsky.social · last yr.

The Pope is in critical condition due to a"polymicrobial infection” of the lungs. What is this? An infection caused by multiple “germs”, most likely bacteria given the severity of the condition. One of many examples on why microbiology research matters. www.livescience.com/health/virus...

What is double pneumonia? Pope Francis's diagnosis explained.

Pope Francis is being treated in hospital for double pneumonia — but what is this condition, and why might the pope be particularly vulnerable to it?

livescience.com