Very excited to announce the workshop "DNA–Protein Crosslinks: Mechanisms and Links to Rare Genetic Disorders", which will take place in Baeza (Spain) from 18–20 November 2026! www.unia.es/estudios-y-a...
Fernando Gomez-Herreros Lab
@fgh-lab.bsky.social
DNA Repair and Gene expression in human disease. Andalusian research lab. Find us at the Institute of Biomedicine of Sevilla https://grupo.us.es/gomezherreroslab/gomezherreroslab/Home.html
Muy contentos de que nuestro último trabajo haya sido elegido como artículo del mes de febrero por la @sebbm.bsky.social @ibis-investigacion.bsky.social
H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death
sebbm.es
New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis-investigacion.bsky.social @unisevilla.bsky.social
H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death
Cell Death & Disease - H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death
rdcu.be
Finally published! Our work on how the #CircadianClock controls DNA repair. This has direct implications for cancer treatment: #Chronotherapy. @CABIMER @UniSevilla rdcu.be/eSwxl
Circadian regulation of homologous recombination by cryptochrome1-mediated dampening of DNA end resection
Nature Communications - The study shows that DNA double-strand break repair follows a circadian rhythm: homologous recombination peaks in the morning and declines by evening. CRY1 regulates CCAR2...
rdcu.be
Our new preprint is out! Great work from Nacho Quesada during his TFG/TFM in our lab, where we found some interesting data on ceramide structure and TORC2 signaling in response to nutrients. Thanks to Anita and Maria Alcaide-Gavilan for helping! www.biorxiv.org/content/10.1...
Uncoupling of nutrient sensing and cell size control by specific defects in ceramide structure
Ceramides are essential structural lipids whose chemical diversity arises from variations in acyl-chain length and sphingoid base modifications, yet how these structural features couple metabolic stat...
biorxiv.org
Excited to see our research published!! 🎉 Amazing project in @fgh-lab.bsky.social at @ibis-investigacion.bsky.social "H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death" www.nature.com/articles/s41...
Kickstarting our Bluesky🦋 account with great news! Our REPAIRome study finally out today in @science.org www.science.org/doi/10.1126/...
A comprehensive genetic catalog of human double-strand break repair
The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...
science.org
#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer. doi.org/10.1038/s415...
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
doi.org
Our latest study is now online! A great collaboration between the @fgh-lab.bsky.social and @enriquedealava.bsky.social Labs, driven by the outstanding work of J. Olmedo-Pelayo at @ibis-investigacion.bsky.social Check it out!
EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism - Oncogene
Oncogene - EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism
nature.com
New preprint from the Lab at @cabimer.bsky.social. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome. www.biorxiv.org/content/10.1...
PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow.
Chromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the genomic localization and protein interactors, respectively, for a prote...
biorxiv.org