Our new paper in Nature Communications is out (Nature Portfolio): How does a single mutation in a ribosomal protein drive blood cancer?
Now out in #Science #Immunology (and also featured on the cover!): Lutz, @simonhaas.bsky.social, Weinhold, & al. use single-cell and spatial multiomics to characterize breakout lesions in #multiplemyeloma, identifying regions of immune and tumor cell coevolution:
Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma
Single-cell and spatial multiomics analyses identify breakout lesions as a hotspot for tumor-immune interactions and diversification.
science.org
ashpublications.org/bloodneoplas...
Predictors of response to venetoclax and therapeutic potential of CDK7 inhibition in multiple myeloma
Key PointsRNA-seq analysis reveals a 6-gene signature that stratifies patients with MM by their predicted response to venetoclax.This study proposes a nove
ashpublications.org
www.nature.com/articles/s41...
Single-cell integration reveals metaplasia in inflammatory gut diseases - Nature
The study provides a comprehensive transcriptomic atlas of the human gastrointestinal tract across the lifespan, highlighting inflammation-induced changes in epithelial stem cells that alter mucosal a...
nature.com
Thrilled to have contributed to this study on understanding infection susceptibility in myeloma! 🧬 Check it out: onlinelibrary.wiley.com/doi/10.1111/... #Myeloma #Hematology #InfectiousDiseases #Research #mmsm
CD71+ erythroid cells promote multiple myeloma progression and impair anti‐bacterial immune response
Multiple myeloma (MM), one of the most frequent haematological malignancies, significantly increases the risk of bacterial infections due to treatment-related side effects, comorbidities and cancer-i....
onlinelibrary.wiley.com
Excited to announce our latest study, where we explored the role of endothelial cells (ECs) and progenitors in #MultipleMyeloma #mmsm (MM) progression! We show how MM bone marrow ECs differ transcriptionally and functionally from those in healthy donors. #hematology #oncology 🧵
