Fiona Whelan

@freewhelan.bsky.social

Biochemistry, cryo-EM, crystallography, dabbling in microED, biophysics, modelling; always up for coffee! Uni of Adelaide for the moment.

Join us for the FIRST combined meeting of the Society of Crystallographers in Australia and New Zealand + the Australian X-ray Analytical Association: Crystal36-AXAA 2026 29th Nov-2nd Dec 2026 - in the beautiful Adelaide Hills town of Hahndorf. ๐Ÿป Register & submit abstracts for early bird savings!

Bild

Hi molbiol fam, setting up a lab - favourite DNA load dye/stain? Bright, cheap, low toxicity? Expect a flurry of requests for anecdotal preferences. I know I could use AI, but I quite like people. ๐Ÿงช๐Ÿงฌ

S7 โšก๏ธโšก๏ธโšก๏ธโšก๏ธโšก๏ธโšก๏ธโšก๏ธ Adnan Sljoka Probing allostery with computational techniques e.g. GPCRs - NMR, Monte carlo simulations, conf dynamics, how allostery regulates dynamics. Dont forget buried waters!! ms timescales of motion... textbook - rigidity theory: Sublinear computation paradigm #lorneproteins2026

BildBild

BioSAXS here too! Coflow autoloader is the primary measurement mode - sec-saxs and batch modes. 12/hour batch; 4/h sec HT batch mode - load, measure, wash. Everything scattering. Subtraxt buffer alone. Process as you acquire. Sec-saxs. Temp controlled. Sheath buffer flow to limit rad damage.

BildBild

The IUPAC Global Womens Breakfast 2026 โค๏ธ๐Ÿ’›๐Ÿ’š๐Ÿ’™๐Ÿ’œ dawned in Lorne with our first gathering on 10th Feb, concluding with a morning tea on the 11th Feb, meaning we've celebrated across international date lines clear into the UNESCO International Day of Women and Girls in Science! That's commitment!! ๐Ÿ’œ๐Ÿ’š๐Ÿค

Bild
Lorne Proteins@lorneproteins.bsky.social ยท 6mo ago

A reminder for tomorrow morning - following Session 9 we have a morning tea to celebrate the UNESCO International Day of Women and Girls in Science, sponsored by Bio21 Platforms! Everyone is welcome to celebrate our fabulous Lorne Proteins women in protein science. ๐Ÿง๐Ÿช

Session 8: The Protein Society Special Lecture - John Kuriyan - Adaptive Capacity of a DNA Polymerase Clamp Loader. Measuring mutagenesis at scale in T4 bacteriophage. T4 del replication machinery. Infects cells, but nothing happens + plasmids with library of replication gene variants...

BildBild

We are joined by Arun Shukla, Indian Institute of Technology, Kanpur, on the structure, function and regulation of GPCRs; and Lauren Porter, NIH, on using AlphaFold's 'black box' to predict the conformations of fold-switching proteins. Lorne Proteins 2026 ๐Ÿ–๏ธ ๐Ÿ”— Register today: www.lorneproteins.org

Bild

๐๐ซ๐ž๐ฌ๐ž๐ง๐ญ ๐š ๐ฉ๐จ๐ฌ๐ญ๐ž๐ซ ๐š๐ญ ๐ญ๐ก๐ž ๐Ÿ“๐Ÿ๐ฌ๐ญ ๐‹๐จ๐ซ๐ง๐ž ๐Ÿ–๏ธ ๐๐ซ๐จ๐ญ๐ž๐ข๐ง๐ฌ ๐‚๐จ๐ง๐Ÿ๐ž๐ซ๐ž๐ง๐œ๐ž ๐Ÿคฉ!! ๐ƒ๐จ๐ง'๐ญ ๐ฆ๐ข๐ฌ๐ฌ ๐ญ๐ก๐ข๐ฌ ๐จ๐ฉ๐ฉ๐จ๐ซ๐ญ๐ฎ๐ง๐ข๐ญ๐ฒ ๐ญ๐จ ๐ฉ๐ซ๐ž๐ฌ๐ž๐ง๐ญ ๐ญ๐จ ๐ž๐ฑ๐ฉ๐ž๐ซ๐ญ๐ฌ ๐ข๐ง ๐ฉ๐ซ๐จ๐ญ๐ž๐ข๐ง ๐ฌ๐ญ๐ซ๐ฎ๐œ๐ญ๐ฎ๐ซ๐ž, ๐Ÿ๐ฎ๐ง๐œ๐ญ๐ข๐จ๐ง, ๐›๐ข๐จ๐œ๐ก๐ž๐ฆ๐ข๐ฌ๐ญ๐ซ๐ฒ, ๐›๐ข๐จ๐ฉ๐ก๐ฒ๐ฌ๐ข๐œ๐ฌ, ๐œ๐จ๐ฆ๐ฉ๐ฎ๐ญ๐š๐ญ๐ข๐จ๐ง๐š๐ฅ ๐›๐ข๐จ๐ฅ๐จ๐ ๐ฒ ๐š๐ง๐ ๐š ๐ฐ๐ก๐จ๐ฅ๐ž ๐ฅ๐จ๐ญ ๐ฆ๐จ๐ซ๐ž... ๐ŸŒŠ โ˜€๏ธ ๐Ÿ ๐Ÿ˜Ž ๐Ÿ”— ๐๐จ๐ฌ๐ญ๐ž๐ซ ๐š๐›๐ฌ๐ญ๐ซ๐š๐œ๐ญ ๐ฌ๐ฎ๐›๐ฆ๐ข๐ฌ๐ฌ๐ข๐จ๐ง ๐œ๐ฅ๐จ๐ฌ๐ž๐ฌ ๐“๐Ž๐ƒ๐€๐˜! www.lorneproteins.org

Bild

Lorne Proteins 2026 ๐Ÿ–๏ธ Leach Lecturer Carol Robinson, Oxford, on establishing mass spec as a viable technique for structure/function studies; and John Kuriyan, Vanderbilt University, on the structural plasticity and evolutionary potential of DNA clamp loaders. ๐Ÿ”— Register now: www.lorneproteins.org

Bild

๐Ÿจ ๐Ÿ›Œ Donโ€™t miss staying at Mantra Lorne โ€“ bookings close 5 December! Make the most of the full Lorne Proteins experience by staying where the action is. ๐ŸŒŠ Ocean views, a short walk to the lecture theatre, and the perfect setting for collaboration. ๐Ÿ˜Ž ๐Ÿ”— Book accommodation here: www.lorneproteins.org

Bild

(ใฃโ—”โ—กโ—”)ใฃ โ™ฅ ๐‡๐š๐ฏ๐ž ๐ฒ๐จ๐ฎ ๐ซ๐ž๐ ๐ข๐ฌ๐ญ๐ž๐ซ๐ž๐ ๐Ÿ๐จ๐ซ ๐‹๐จ๐ซ๐ง๐ž ๐๐ซ๐จ๐ญ๐ž๐ข๐ง๐ฌ ๐ฒ๐ž๐ญ? โ™ฅ Join leading researchers, students and industry partners in Lorne ๐Ÿ–๏ธ for an inspiring week of science and collaboration. Secure your place today and ensure youโ€™re part of the 2026 program. ๐Ÿ”— Register now: www.lorneproteins.org

Bild

Delighted to be involved in this study aiming to address limitations in mRNA nanoparticle stability to improve access to critical vaccine technologies-out now in Advanced Science. Cryo-EM imaging & statistical analysis of LNP microstructures shows reduced degradation at elevated temps ๐Ÿซฐ

Replacing Helper Lipids With Cationic Lipids Enhances mRNA Lipid Nanoparticles Stability in Solution

Partial Replacement of phospholipid lipid by cationic lipid improves storage stability of commercial mRNA LNPs by stabilizing their internal microstructure.

advanced.onlinelibrary.wiley.com