👀Robust photoactivatable fluorescent markers with red and #far-red emission for live-cell imaging are difficult to find? Not anymore! Researchers at our Optical Nanoscopy Department have developed new far-red markers. Successfully used in STED, PALM and MINFLUX nanoscopy!🔬 doi.org/10.1016/j.ch...

🚀 We’re hiring! EMBL TechDev Internship (TDI25-14) We’re looking for an organic chemist to help develop novel fluorogenic HaloTag ligands for deep-tissue imaging. You’ll contribute to molecular design and run in silico, in vitro, and microscopy-based assays to quantify fluorophore performance.

I’m very happy that our paper is now published in Angewandte Chemie! 👏 A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells. ↪️ onlinelibrary.wiley.com/doi/full/10.... Big thanks again to all co-authors (especially Bego) and collaborators for their contributions! 👏

A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells

Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self-labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a ...

onlinelibrary.wiley.com

Claire Deo@clairedeo.bsky.social · 9mo ago

Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....

Excited to share the second chapter of my PhD work - Photoclickable HaloTag Ligands for Spatiotemporal Multiplexed Protein Labeling on Living Cells! 🥳 A big thank you to @clairedeo.bsky.social and all co-authors who contributed to this work. ➡️ www.biorxiv.org/content/10.1...

Claire Deo@clairedeo.bsky.social · 9mo ago

New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇 www.biorxiv.org/content/10.1...