Garrett Fogo
@garrettfogo.bsky.social
Postdoc, Brigham and Women’s Hospital Young-Pearse Lab • NIA K00 Fellow • Umich PhD
TYP lab takes Chicago! Grateful for the organizers putting together another great ROSMAP meeting and for the opportunity to share our work! Tracy, our amazing postdoc @garrettfogo.bsky.social and PhD student Olivia Pembridge all gave great talks! #RUSH #ROSMAP
Great study by Katlynn Emaus from our time in the Sanderson Lab @sandersonlab.bsky.social out now in Journal of Cerebral Blood Flow and Metabolism journals.sagepub.com/doi/10.1177/...
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Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!! link.springer.com/epdf/10.1007...
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis
link.springer.com
New TYP lab publication from co-authors Zach Augur and @garrettfogo.bsky.social on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons - Acta Neuropathologica Communications
Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral scleros...
link.springer.com
actaneurocomms.biomedcentral.com/articles/10....
Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons - Acta Neuropathologica Communications
Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral scleros...
actaneurocomms.biomedcentral.com
Thankful to have contributed to this great review by Katlynn Emaus from @sandersonlab.bsky.social on cardiolipin in mitochondrial dynamics and mitohagy www.nature.com/articles/s41...
The role of cardiolipin in mitochondrial dynamics and quality control in neuronal ischemia/reperfusion injury - Cell Death & Disease
Cell Death & Disease - The role of cardiolipin in mitochondrial dynamics and quality control in neuronal ischemia/reperfusion injury
nature.com
Thrilled to share my first first-author paper is out @cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes. Read here www.sciencedirect.com/science/arti...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…
sciencedirect.com
The final bit of my PhD work from the Sanderson Lab is now out in iScience! Agent-based modeling of neuronal mitochondrial dynamics using intrinsic variables of individual mitochondria: iScience www.cell.com/iscience/ful...
Agent-based modeling of neuronal mitochondrial dynamics using intrinsic variables of individual mitochondria
Mitochondrial networks undergo remodeling to regulate form and function. The dynamic nature of mitochondria is maintained by the dueling processes of mitochondrial fission and fusion. Dysfunctional mi...
cell.com
Happy to share a large part of my PhD work that is now published in Autophagy! www.tandfonline.com/doi/full/10....
Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion
Mitochondrial damage and dysfunction are hallmarks of neuronal injury during cerebral ischemia-reperfusion (I/R). Critical mitochondrial functions including energy production and cell signaling are...
tandfonline.com