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@gastrulomicslab.bsky.social

Based in Freiburg/Germany in the Arnold-Lab, we are enthusiastic about various aspects of gastrulation: from cell behavior during morphogenesis, signals and transcriptional control, to dynamic chromatin regulation, and even biophysics of cells & tissues

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@gastrulomicslab.bsky.social · 2y ago

Excited to share our latest paper in DevCell! We show how EOMES and the SWI/SNF complex collaborate to drive chromatin remodeling, establishing mesoderm and endoderm differentiation potential. Read the full paper here: www.cell.com/developmenta...

EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling

Schröder et al. describe the molecular functions of the Tbx factor Eomes, which, together with the SWI/SNF chromatin remodeling complex, establishes enhancer accessibility at mesoderm and endoderm (ME...

cell.com

@gastrulomicslab.bsky.social · 2y ago

Congrats Chiara to have your beauty paper out: www.cell.com/developmenta...

EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling

Schröder et al. describe the molecular functions of the Tbx factor Eomes, which, together with the SWI/SNF chromatin remodeling complex, establishes enhancer accessibility at mesoderm and endoderm (ME) genes during lineage specification of pluripotent cells. Eomes enables broad ME lineage competence for gene activation that relies on additional signal-induced transcription factors.

cell.com