A beautiful spotlight on our recent work on the polarity maintenance in bleb-based motility in metastatic cancer cells by @vickysanzmoreno.bsky.social and Dipanwita Das is published in Developmental Cell.
Yuki Maekawa
@gatohamu.bsky.social
PhD student quietly investigating cell biology and cell migration.
SBIs are visible.
Anh Hoang Le, PhD 🏳️🌈🏴🇻🇳@anhhle2702.bsky.social · 2mo agoI love these PIP3 biosensors because it labels the plasma membrane so well. You can see the cell's edge so clearly along with any intracellular vesicles. Also, this cell is so blebby. This video was taken when I was still working on endocytosis :D Good old times! #FluorescenceFriday
Excited to share our new paper, now published in Nature Cell Biology! 🎉 We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces? www.nature.com/articles/s41556-026-01981-1
CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology
Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.
nature.com
Found a fascinating paper. Importin-β1 functions as a chromatin sensor to position the contractile ring for cytokinesis: Current Biology www.cell.com/current-biol...
Importin-β1 functions as a chromatin sensor to position the contractile ring for cytokinesis
This study by Brancheriau et al. reveals a mechanism that cells use to sense chromosome position to properly divide. This pathway may be more dominant in cells with higher ploidy, such as cancer cells...
cell.com
