Promising therapies need stronger clinical evidence. This review explains how autologous ozonized blood transfusion reduces #OxidativeStress and #inflammation while highlighting barriers to wider adoption. #NRF2 #NFκB #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

#GutMicrobiota, metabolites, and vitamin levels shape #ThyroidCancer progression. Stage‑specific microbial shifts, metabolic reprogramming, and reduced vitamins C/D highlight stakes for early detection and biomarker discovery. #OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Learn how a #lncRNA fuels #ColorectalCancer. This study identifies AC004854.2 as a driver of c-MYC transcription through the SOX4/AC004854.2/PUF60 axis, highlighting a promising #biomarker and therapeutic target beyond WNT/β-catenin. #GenesAndDiseases: doi.org/10.1016/j.ge...

What if #aging cells keep inflammation alive by leaking their own DNA? This review shows how #MitochondrialDNA leakage fuels cellular senescence and highlights blocking its release as a promising anti-aging strategy. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

📢 Deadline Approaching! Apply by 28 Sept for the 4th ESTRO RTT Workshop! Collaborate globally & join new RTT Working Groups. 📅 1 Dec 2026 (Online) 📅 25 Feb 2027 (Online) 📍25 May 2027 (#ESTRO27, Milan) 👉Explore themes & apply: https://bit.ly/4d5a71O #RTT #ESTRORTT26 #Radonc

Last call for established profs: Letters of Intent for the Research Professorship in Ovarian Cancer are due 9/23. Secure flexible funding to support your overall research activities & train the next generation of leaders. Supported by @conquercancer.bsky.social. Submit ⏩https://bit.ly/4iifmPj

Register by September 25 to get the lowest rates for the San Antonio Breast Cancer Symposium (December 8-11), presented by UT Health San Antonio in collaboration with the AACR. Learn more: buff.ly/ZJJqL8Y #SABCS26

Learn how DYRK kinases shape cancer therapy. This review shows how DYRK proteins regulate #DNADamageResponse and highlights DYRK inhibitors as promising #PrecisionOncology strategies to exploit cancer-specific DNA repair vulnerabilities. #GenesAndDiseases: doi.org/10.1016/j.ge...

Precision cancer therapy starts with RNA regulation. This review highlights how the #N6methyladenosine (m6A) demethylase FTO drives #GastrointestinalCancer and why FTO inhibitors are emerging as promising therapeutic targets. #OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Learn what drives #IntervertebralDiscDegeneration. This study identifies SPP1⁺ macrophages as key mediators of matrix damage and shows that SPP1-silenced #exosomes protect intervertebral discs, offering a promising therapeutic strategy. #GenesAndDiseases: doi.org/10.1016/j.ge...

How do uniform tissues become complex? This review uses #SkinAppendages to show how #SymmetryBreaking—via morphogens, mechanics, and microenvironmental cues—drives patterning, stem cell regulation, and disease remodeling. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Can force-sensing ion channels improve #orthodontics? This review shows how #PiezoChannels regulate tooth movement, pain, and dentofacial development, making them promising therapeutic targets. #craniofacial #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Is #ImmuneAging undermining #GastrointestinalCancer therapy? This review links T cell exhaustion, SASP, and microbiota-driven inflammation to resistance, spotlighting senolytics and microbiota-targeted strategies. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

ESMO's new Clinical Trials Funding initiative supports independent academic pragmatic clinical trials to improve #CancerCare and patient outcomes. Open to academic institutions, hospitals, research groups. Application deadline: 1 November 2026 https://ow.ly/v8n850ZLX3q

Submit an abstract by October 29 for the AACR Special Conference on Redefining Lung Cancer (January 14-17; San Diego), held in association with the AACR Lung Cancer Task Force and chaired by Charles Swanton. Learn more: buff.ly/keg0wCw #AACRlung27

📢Neuroendocrine Cancer Foundation @netcancerfound.bsky.social announced “Luncheon with the experts” with Dr. Aman Chauhan to be live streamed on September 17th, 2026, 9 am Pacific - over Facebook Live and YouTube Live. ✅Find out more: incalliance.org/luncheon-wit... #LetsTalkAboutNETs

Why is #EarlyOnsetColorectalCancer more aggressive? This study links the PPARγ–EMP1 axis to lipid-driven immune suppression, revealing a target that restores CD8⁺ T-cell function and improves anti-PD-1 therapy. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Better #CancerImmunotherapy requires tackling hidden immune barriers. This review highlights how dysfunctional #Bcells suppress anti-tumor immunity and outlines strategies to reprogram the #TumorMicroenvironment. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Learn how betaine protects bone. This study shows betaine blocks #ferroptosis, restores osteogenesis via the ABCG1–HMOX1 axis, and emerges as a promising therapy for #RenalOsteodystrophy. #ChronicKidneyDisease #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

What drives synaptic dysfunction in #AutismSpectrumDisorder (ASD)? This study identifies ADAM10-mediated #Ncadherin cleavage as a potential therapeutic target linked to impaired synaptic plasticity. #ValproicAcid #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

What if #noncodingRNAs encode disease-driving proteins? This review highlights #exosome-derived ncRNA peptides as promising #biomarkers, therapeutic targets, and next-generation treatments across multiple diseases. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Precision medicine is transforming #cholangiocarcinoma care. This review highlights advances in targeted therapies and #immunotherapy while addressing challenges such as drug resistance and biomarker discovery. #TumorMicroenvironment #GenesAndDiseases: doi.org/10.1016/j.ge...

Immerse yourself in cutting-edge science and learn the solution-focused strategies that can elevate your patient outcomes at #GI27. Registration is now open, so secure your spot today to save: https://bit.ly/4cmBW5v

Submit an abstract by September 23 for the AACR Special Conference on Advances in the Pathogenesis and Immune Therapies of Liver Cancer (December 6-8; Austin, Texas), chaired by Richard S. Finn, Josep Llovet, and Jessica Zucman-Rossi. Learn more: buff.ly/QuyRLts #AACRliver26 @zucmanrossi.bsky.social

📣 #ESMO26: Join Prof. James Larkin, Scientific Committee Co-Chair, to exchange perspectives, debate emerging evidence, and discuss the future of cancer prevention, diagnosis, and treatment. ⏰ Late registration deadline: 16 September 2026 🔗 https://ow.ly/q9GM50ZJcZh #esmomeetings

Restoring blood flow can also damage the heart. This review shows how #inflammasomes drive #IschemiaReperfusionInjury and highlights therapies targeting these inflammatory pathways to improve recovery. @CUHKofficial #GenesAndDiseases: doi.org/10.1016/j.ge...

Why do some breast cancers spread despite slower tumor growth? This study identifies mdig as a suppressor of #metastasis in #TripleNegativeBreastCancer, revealing a promising target to limit cancer spread. @stonybrooku.bsky.social #GenesAndDiseases: doi.org/10.1016/j.ge...

Can disease-causing proteins be eliminated, not just blocked? This review highlights #PROTAC technology as a promising strategy to target kidney disease drivers and advance precision therapies in #nephrology. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

Not all airway #CiliatedCells are alike. This study maps their diversity, revealing region-specific antioxidant defenses and disease-linked signatures that could guide new therapies for #asthma and #COPD. #RespiratoryDiseases #OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Why bone formation fails remains unclear. This study identifies JAM3 as a key regulator that stabilizes #LRP5, promotes #osteoblast formation, and preserves bone mass, revealing a promising target for skeletal disorders. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...