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Diagnostics MDPI on X: "🎊First article published in the Special Issue 'Point-of-Care Testing (#POCT) for Infectious Diseases' "An ERA-CRISPR/Cas12a Method for Highly Sensitive Detection of Human #Adenovirus Type 55" by Letian Zhang et al. 📖Check out the full publication at https://t.co/7BA6Ggc7SO https://t.co/LZvZ7DIAIB" / X

🎊First article published in the Special Issue 'Point-of-Care Testing (#POCT) for Infectious Diseases' "An ERA-CRISPR/Cas12a Method for Highly Sensitive Detection of Human #Adenovirus Type 55" by Letian Zhang et al. 📖Check out the full publication at https://t.co/7BA6Ggc7SO https://t.co/LZvZ7DIAIB

x.com

Weakly supervised deep learning-based detection of serous tubal intraepithelial carcinoma in fallopian tubes

Serous tubal intraepithelial carcinoma (STIC) is an uncommon, non-invasive carcinoma that occurs more frequently in individuals with germline BRCA mut…

sciencedirect.com

Correlation between EpCAM expression and cervical lymph node metastasis in papillary thyroid carcinoma: a study integrating ultrasonographic features - BMC Cancer

Objectives The epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that is overexpressed in various epithelial tumors and has been associated with tumor aggressiveness and unfavo...

bmccancer.biomedcentral.com

Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification

Wala et al. identify recurrent focal BRD4 deletions in tumors harboring larger amplifications, suggesting that these deletions may serve to limit toxic BRD4 overexpression. A CRISPR-Cas9 cell line mod...

cell.com

Endocrine Therapy Omission in Estrogen Receptor–Low (1%-10%) Early-Stage Breast Cancer

PURPOSEAdjuvant endocrine therapy (ET) improves overall survival (OS) in estrogen receptor (ER)–positive early-stage breast cancer (BC). However, the benefit of ET for those with ER-low BC (ER 1%-10%)...

ascopubs.org

Study shows how new antibody therapy works against ovarian cancer

Research has shed light on how a new type of antibody treatment reactivates patients’ immune cells to fight ovarian cancer.

kcl.ac.uk

Proposal for an optimised definition of adverse pathology (unfavourable histology) that predicts metastatic risk in prostatic adenocarcinoma independent of grade group and pathological stage

We show that specific histological patterns of prostatic adenocarcinoma are highly sensitive for predicting metastatic potential, independent of grade group and pathological staging. We propose a sim....

onlinelibrary.wiley.com

JCI Insight - Prognostic importance of direct assignment of parent of origin via long-read genome and epigenome sequencing in retinoblastoma

insight.jci.org

An inflammatory biomarker signature of response to CAR-T cell therapy in non-Hodgkin lymphoma - Nature Medicine

A preinfusion circulatory inflammation biomarker-based signature predicts the likelihood of treatment failure in patients with non-Hodgkin lymphoma who were treated with CAR-T cell therapy, with an in...

nature.com

Prognosis, clinicopathological characteristics, and treatment patterns of patients with ER-intermediate-positive breast cancer undergoing long-term follow-up

Estrogen receptor (ER) expression levels in breast cancer tissue predict the efficacy of endocrine therapy and the prognosis of breast cancer patients. Recently, it was reported that the prognosis of ...

esmoopen.com

An in vivo screen identifies NAT10 as a master regulator of brain metastasis

NAT10 is identified as a master regulator of brain metastasis and a potential target for treating metastasis.

science.org

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation

Somatic mutations that increase hematopoietic stem cell (HSC) fitness drive their expansion in clonal hematopoiesis (CH) and predispose to blood cancers. Although CH frequently occurs with aging, it r...

biorxiv.org

The role of renal and liver function in clinical ctDNA testing

Circulating tumor DNA (ctDNA) has high clinical potential in early cancer detection. The renal system and the liver are involved in clearing circulating cell free DNA (cfDNA) from the blood. Recent st...

journals.plos.org

Immunophenotype of CAR T cells and apheresis products predicts response in CD22 CAR T cell trial for B cell acute lymphoblastic leukemia

Although CAR T cell therapy is increasingly used to treat relapsed B cell acute lymphoblastic leukemia (ALL), 20%–30% of patients do not respond, and …

sciencedirect.com

Deciphering Genomic Complexity of Multiple Myeloma Using Optimized Optical Genome Mapping

The genomic evaluation of multiple myeloma in routine diagnostics involves isolating plasma cells expressing CD138, usually followed by fluorescence in situ hybridization analyses. However, cell sorti...

jmdjournal.org

Comparison of targeted RNA sequencing platforms for oncogenic fusion detection in non-small cell lung cancer

Oncogenic fusion detection is an essential part of clinical diagnosis and management of non-small cell lung carcinoma. Numerous methods are available for detection of oncogenic fusions in the clinical...

jmdjournal.org

γδ T cells as sensors of ectopically expressed intracellular proteins - Cellular & Molecular Immunology

Cellular & Molecular Immunology - γδ T cells as sensors of ectopically expressed intracellular proteins

nature.com

Second primary malignancies following CAR T-cell therapy in patients with hematologic malignancies - Journal of Hematology & Oncology

Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of patients with relapsed/refractory (R/R) hematologic malignancies, including B-cell lymphomas and multiple myeloma (MM...

jhoonline.biomedcentral.com

Quantitative characterization of cell niches in spatially resolved omics data - Nature Genetics

NicheCompass is a graph variational autoencoder approach for identifying cellular niches defined by cell–cell communication and other interactions, applicable to a broad variety of spatial multi-omic ...

nature.com

Oncology Here & Now Podcast: Breast Cancer with Dr. Maryam Lustberg & Dr. Elisa Agostinetto

YouTube video by OncoAlert 360

youtu.be

Long read sequencing enhances pathogenic and novel variation discovery in patients with rare diseases - Nature Communications

Here the authors illustrate how long read whole genome sequencing can enhance the diagnosis of patients with rare diseases relative to standard methods, through identification of comprehensive small a...

nature.com

Cerebrospinal fluid proteomics exerts predictive potential for immune effector cell-associated neurotoxicity syndrome (ICANS) in CAR-T cell therapy - Leukemia

Leukemia - Cerebrospinal fluid proteomics exerts predictive potential for immune effector cell-associated neurotoxicity syndrome (ICANS) in CAR-T cell therapy

nature.com

Emerging fusion-associated mesenchymal tumours: a tabular guide and appraisal of five ‘novel’ entities

Aims The field of molecular pathology has undergone significant advancements in the clinical impact of sarcoma diagnosis, resulting in challenges to nosology of bone and soft tissue tumours. The surge...

jcp.bmj.com

Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics - Nature Communications

Existing methods for identifying differential gene expression signatures for clinical case/control analyses with high throughput sequencing data present various challenges. Here, the authors develop B...

nature.com

Short Telomere Syndrome and Interstitial Lung Disease - American College of Chest Physicians

Get an overview on the connection between short telomere syndrome and interstitial lung disease.

chestnet.org

A pathologist's guide for the diagnostic workup of paediatric central nervous system tumours

Advances in precision medicine and our understanding of the molecular drivers of central nervous system (CNS) tumorigenesis in children have broadened the scope of diagnostic testing that is required ...

pathologyjournal.rcpa.edu.au

Synthetic short mRNA prevents metastasis via innate-adaptive immunity - Nature Communications

Extracellular mRNAs are found to play an important role in premetastatic organs. Here this group reports the non-vesicular extracellular IL1β-mRNA complexes binding to ZC3H12D followed by the transloc...

nature.com

Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma

PURPOSESurvival for patients with multiple myeloma (MM) has improved but outcomes remain heterogeneous. Consistent diagnostic identification of high-risk disease is desirable to address unmet patient ...

ascopubs.org