Why can cells keep protein aggregation under control for years and then suddenly tip into disease? Our new JCP paper introduces a simple phase-plane model for in vivo protein aggregation that captures the tug-of-war between aggregate formation and clearance in cells. pubs.aip.org/aip/jcp/arti...

A universal phase-plane model for in vivo protein aggregation

Neurodegenerative diseases are driven by the accumulation of protein aggregates in the brain of affected individuals. The aggregation behavior in vitro is well

pubs.aip.org

Thrilled to see our recent preprint on tipping points in neurodegeneration highlighted on Alzforum! Read it here: www.alzforum.org/news/researc.... Many thanks to Jessica Shugart for the engaging coverage, and to everyone involved in this exciting project at the @ukdri.ac.uk and elsewhere!