A bit late, but excited to share our new PNAS paper! We uncovered a molecular switching mechanism in COG0523 proteins driven by self-activation via an arginine finger in the CTD. Read more details here: link.growkudos.com/1e5gtwm2lmo

Huge congratulations to the most recent PhD in our lab, @jsrocchio.bsky.social, on his first-author paper in ACS Infectious Diseases! Joey built this beautiful toolkit for probing peptidoglycan biosynthesis and antibiotic action in A. baumannii cells. 🦠 #IUResearch tinyurl.com/46d8x9eb

Monitoring UDP-MurNAc (UM)-Stem Peptide Intermediates from the Cellular and Recombinant Acinetobacter baumannii MurCDEF Pathway

Increasing multidrug resistance in nosocomial, opportunistic bacterial pathogens motivates a need to exploit metabolic pathways of therapeutic value. Here, we describe a one-pot reconstitution of the ...

pubs.acs.org

Excited to co-chair the 2026 Gordon Research Seminar (GRS) on Thiol-Based Redox Regulation & Signaling with Taylor Covington, a meeting for early career researchers in redox research 📍 Castelldefels (Barcelona), Spain ☀️ 📅 July 11–12, 2026 #Redox #Thiols #EarlyCareerResearchers More details ↓

Excited to share our new preprint on self-S-sulfonation in persulfide dioxygenase CstB from S. aureus, unveiling how it detoxifies thiol persulfides via a dynamic loop shuttle to produce thiosulfate, no sulfite released! Crystal structures, MS, & mechanistic insights included. tinyurl.com/4sr3ayz5

Huge congratulations to grad student @katherinelegg.bsky.social on her new Science Advances paper, “CH•••S hydrogen bonds drive molecular recognition of ergothioneine by the microbial transporter”! 🎉 A beautiful collaboration of biochemistry, structural biology, NMR, and MD. tinyurl.com/3wxchjhp

Fantastic science this weekend at @iuqcb.bsky.social's Watanabe Symposium. Our grad student @jsrocchio.bsky.social even won the student poster competition! Thanks to @tripletstatesguy.bsky.social, @glycocode.bsky.social and all other speakers for great talks! #IUresearch

Our grad student @katherinelegg.bsky.social was a co-author on this recent publication in collaboration with the Reniere lab at UW! @gramnegativity.bsky.social was first author and has a great thread below going over the paper. Congrats Katherine, Lauren and all those involved!

Lauren@gramnegativity.bsky.social · last yr.

The latest (and penultimate! 👀) article from the @mreniere.bsky.social lab is finally out! I’m really proud of this one in which I took a genetic approach (shocking, I know) to probe how Staph is able to grow in cystic fibrosis sputum: journals.asm.org/doi/10.1128/...

Our lab has two talks coming up! 1️⃣ @emmcraechem.bsky.social is on a queer in academia panel at the OASIS conference tomorrow (Apr. 5th)! 2️⃣ @jsrocchio.bsky.social is giving a talk about a COG0523 protein in Ab at QCB evening on Apr. 17th! Both events require registration! See flyers for more details!

Don't miss Dr. Giedroc's talk on Tues., Apr. 9 at 9AM EDT on the Biometals webinar! It's an opportunity to learn more about grad student @mkosterb.bsky.social's work on metalloproteome integrity (with the Weerapana lab, Skaar lab and @chazinwalter.bsky.social). Register: shorturl.at/38yWM #biometals

📅 Save the date! 1️⃣ Fri, Apr 11: 1st Annual Undergrad. Chemical Biology Symposium Talks, poster session, facility tour, pizza, no registration! 2️⃣ Sat, Apr 12: 14th Annual Watanabe Symposium Talks, lunch, poster session, registration required! Questions? avemcfar@iu.edu or acbach@iu.edu #IUResearch

Our annual QCB fellowship competition for 2025 is now open! We're offering 3-5 awards for PhD students in QCB trainer labs, including 1-2 for international students. Apply by April 13, 2025, midnight. Spread the word!🧑‍🔬 #QCBFellowship #IUResearch #PhDFunding iuqcb.indiana.edu/about/traine...

Our lab is seeking a highly motivated postdoctoral research associate to study zinc metallochaperones from the COG0523 superfamily of small GTPases. Apply here: shorturl.at/UmQYM or send application materials to Prof. Giedroc directly at giedroc@iu.edu. Looking for strong biochemists; please share!

Congratulations to our long-time collaborator Eric Skaar on receiving this prestigious Award in Molecular Biology from the National Academy of Sciences! www.nasonline.org/award/nas-aw...

NAS Award in Molecular Biology – NAS

The NAS Award in Molecular Biology is supported by Pfizer Inc. and recognizes a recent notable discovery by a young scientist (no older than 50) who is a citizen of the United States. The award is pre...

nasonline.org

@betainverse.bsky.social, our former research scientist, is now the Director of the METACyt Biomolecular NMR Laboratory! She'll oversee the training and operation of our state-of-the-art 600 MHz and newly installed 800 MHz Bruker Ascend instruments. Congratulations, Katie! 🧲 #NMR #IUResearch

Our review on bacterial metallostasis is now online in Chemical Reviews! This collaboration by the Giedroc (@betainverse.bsky.social and @jsrocchio.bsky.social) and Capdevila labs delves into bacterial metal regulation. 🦠 #Microbiology #ChemicalReviews #BacterialMetallostasis doi.org/10.1021/acs....

Drs. @betainverse.bsky.social and Diaz-Rodriguez purified EgtU, an ABC transporter that imports ergothioneine into bacterial cells, paving the way for structural and functional studies of uptake systems in S. pneumoniae and other pathogens. Kudos to the team! #BacterialTransporters shorturl.at/AUPTJ

Expression and purification of the intact bacterial ergothioneine transporter EgtU

The bacterial ATP-binding cassette (ABC) transporter EgtU is responsible for uptake of the cellular antioxidant ergothioneine in Streptococcus pneumon…

shorturl.at

Our very talented undergrad, Clare Frawley, presented her first poster today at the Indiana University Undergraduate Research Conference! 📊 🌟 Clare has been working with our grad student @jsrocchio.bsky.social on unnatural amino acid incorporation for live-cell cross linking studies! #IUResearch

🎉 Exciting milestone! Our paper on CiaR-controlled Ccn sRNAs modulating Zn-resistance in S. pneumoniae is out! Congrats to @iuqcb.bsky.social's @mkosterb.bsky.social and Dr. Abigail Garrett. This marks Prof Giedroc's 200th peer-reviewed paper!🔬🧬 #sRNAs #MetalHomeostasis shorturl.at/lMFM3

The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance

Author summary Zn and Mn are essential micronutrients for many bacteria, including Streptococcus pneumoniae. While Zn performs vital structural or catalytic roles in certain proteins, in excess, Zn ca...

shorturl.at

🎉 Our grad student @katherinelegg.bsky.social is a co-author on a new preprint about the genetic requirements and nutrient needs for Staphylococcus aureus growth in cystic fibrosis sputum. Congrats to @gramnegativity.bsky.social and all involved! shorturl.at/yfZQA 🧬 #CysticFibrosis #Microbiology

Analysis of genetic requirements and nutrient availability for Staphylococcus aureus growth in cystic fibrosis sputum

Staphylococcus aureus is one of the most common pathogens isolated from the lungs of people with cystic fibrosis (CF), but little is known about its ability to colonize this niche. We performed a Tn-s...

pmc.ncbi.nlm.nih.gov

Dr. Giedroc contributed to "Trace Metals and Infectious Diseases," exploring metals' roles in microbial-host interactions. Edited by Eric Skaar and Jerome Nriagu, the volume shows metallobiology's significance for infectious disease research. 📚🔬 #Metallobiology #InfectiousDiseases shorturl.at/ua8kq

Trace Metals and Infectious Diseases

Experts explore the influence of trace metals on the pathogenesis of infectious diseases.Many parts of the world in which common infectious diseases are ende...

mitpress.mit.edu

As the lab migrates over to #ChemSky, we are debuting our new lab logo designed by our own graduate student @jsrocchio.bsky.social. Happy to be here!