Giovanni Schiesaro
@giovanschi.bsky.social
PhD student at DTU Biosustain. Working on fungal GPCRs and more. - 1/3 of Biologi per la scienza
journals.asm.org/doi/10.1128/...
Spatiotemporal compartmentalization of NADPH oxidase signaling coordinates cell fusion and predatory behavior in nematode-trapping fungi | mBio
Reactive oxygen species (ROS) are not only toxic byproducts of mitochondrial activity but also important signaling molecules in eukaryotes. To fulfill this signaling role, ROS production must be tight...
journals.asm.org
The role of fungal G protein-coupled receptors in interspecies cell-cell communication academic.oup.com/femsre/advan...
The role of fungal G protein-coupled receptors in interspecies cell-cell communication
Abstract. Fungi occupy a wide range of ecological niches in which they compete or associate with other organisms through the perception of external signals
academic.oup.com
Our review on the role of fungal G protein-coupled receptor (GPCRs) in interspecies cell-cell communication is finally out. academic.oup.com/femsre/artic...
The role of fungal G protein-coupled receptors in interspecies cell–cell communication
The review covers recent advances on fungal GPCRs, including their molecular interactions and physiological roles. Illustration created with BioRender.com.
academic.oup.com
Studying fungal organisms can be challenging, and we need more versatile tools or protocols that could be easily transferred from one fungal organism to another.
Finally out! www.nature.com/articles/s41...
A yeast surface display platform for characterizing CAR T cell responses to cancer antigens - Nature Communications
Chimeric antigen receptor T (CAR-T) cell therapy uses engineered donor T cells to recognize and eliminate cancer cells through cognate antigen-dependent activation. Here authors develop an alternative...
nature.com
Can yeast help us fight fungal crop diseases?🌾 A yeast mating platform for multiplex screening of fungal GPCR–ligand interactions www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
So cool, a novel archaeon with a super small genome and no metabolic genes! "An unprecedented level of metabolic dependence on a host, a condition that challenges the functional distinctions between minimal cellular life and viruses." www.biorxiv.org/content/10.1...
A cellular entity retaining only its replicative core: Hidden archaeal lineage with an ultra-reduced genome
Defining the minimal genetic requirements for cellular life remains a fundamental question in biology. Genomic exploration continually reveals novel microbial lineages, often exhibiting extreme genome...
biorxiv.org
This paper makes me CACKLE. Every so often a fungus comes along that is like "oh, you think you understand genetics? lol. You're cute." and completely upends everything we thought we knew. Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science 🧪 #academicsky 🧵
Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi
Nuclei define eukaryotes, enabling macromolecular compartmentalization and cellular regulation. Each nucleus is believed to contain one or more haploid sets of chromosomes (1N). However, we discovered...
science.org
Can we link satellite images and fungal community composition in the soil? Yes! How? Check this paper. It was a pleasure to collaborate on this story. Big congrats to Mathies and all the co-authors. www.nature.com/articles/s43...
Exploring crop health and its associations with fungal soil microbiome composition using machine learning applied to remote sensing data - Communications Earth & Environment
Crop health is improved by abundance of beneficial soil fungal genera and reduced by abundance of soil fungal pathogens, according to analysis of satellite-derived normalized difference vegetation ind...
nature.com
👀
Aaron Vogan@fungage-lab.bsky.social · last yr.We did it! We caught Starship #transposons moving between #fungal species in the lab, including between species separated by ~100my. We think Starships are a mediator of HGT in fungi, akin to conjugative elements in bacteria. Check out the preprint. www.biorxiv.org/content/10.1...
Out now! We consolidated >600 Dutch yeast and characterised their activity against spoilage yeasts and relevant human and plant pathogens, focusing on yeasts that secrete antifungal proteins. Great resource for biocontrol and beyond. pubmed.ncbi.nlm.nih.gov/39875071/
Half way PhD presentation: done 👍🏻. Our first story “A synthetic platform for multiplex screening of cell-cell communication between soil fungi” is already available on bioarchive: www.biorxiv.org/content/10.1...
I highly recommend the documentary "Hunt for the Oldest DNA" on the scientific journey of Eske Willerslev and collaborators. Good science requires perseverance and... time. If your PhD didn’t meet your expectations, remember that there are projects that have lasted 16 or more years.
